Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Dorsal root ganglion"”.
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The Sandwich Synapse: Trans-glial Signaling Between Neuronal Somata in the Dorsal Root Ganglion
The dorsal root ganglion (DRG) contains the cell bodies of primary somatosensory neurons that form axonal connections for the transfer of sensory input from the peripheral nerve receptor to the spinal cord in the central nervous system. In general, DRG neuronal somata (NS) are each enveloped by …
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A novel surgical tool for stimulation paddle delivery to the dorsal root ganglion of the spine
Dorsal root ganglion (DRG) stimulation is a novel method of treating chronic pain in which a lead with a set of electrodes is placed on the nerve root of the spinal cord above the pain site. This method shows promise over traditional spinal cord stimulation due to the its localized nature as …
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Sequential Changes of CX3CR1 in Dorsal Root Ganglion in a Rat Model of Lumbar Disc Herniation
"말초 신경손상 중 요추부 추간판 탈출시의 신경병증성 통증은 기계적 압박보다는 생화학적 염증반응에 의한 것으로 알려져 있으며 통증의 전달에 있어서 사이토카인, 케모카인, 프로스타글란딘 등의 다양한 염증 매개체가 관여하는 것으로 되어 있다. 이중에서 케모카인 중의 하나인 프랙탈카인(CX3CL1)은 말초신경 손상의 경우 신경세포에서 유리되어 척수 후각의 미세아교세포를 활성화함으로써 통증을 촉진하는 것으로 보고하고 있다. 수핵을 이용한 요추간판 탈출증 모델 연구에서 케모카인중 하나인 프랙탈카인과 프랙탈카인의 수용체인 CX3CR1에 대한 …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… is associated with peripheral neuropathy and dorsal root ganglia neurons are the putative target, however the mechanism of toxicity is currently unknown. Recent evidence suggests that copper transporters may be implemented in the transport and neurotoxicity of platinum drugs. We hypothesis …
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Alzheimer's Disease and Amyloid Beta: Effects of amyloid beta on hippocampal and dorsal root ganglion neurons' electrophyiology and morphology
… and morphology of isolated hippocampal and dorsal root ganglion (DRG) neurons in order to test whether the effects of Aβ exposure and clearance are exclusive to central nervous system neurons. Isolation and culture of hippocampal and DRG neurons were performed. By exposing neurons to …
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The Role of SDF1/CXCR4 Signaling in Opioid-Induced Hypernociception
… in expression of SDF1 and CXCR4 signaling in the dorsal root ganglion following repeated morphine administration. Secondly, I investigated if opioid or non-opioid signaling was involved in the development of OIH and which of these receptor signaling cascades was responsible for changes in …
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A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
… mediated by specific isoforms of Navs present in dorsal root ganglion (DRG) and trigeminal ganglion (TG) sensory neurons. Nav1.7 is the most abundantly expressed isoform in DRG and TG neurons, and an isoleucine to valine mutation at residue 136 in the voltage- sensing domain (VSD) results in the …
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Role of Laminins in the Development of the Peripheral Nervous System
… and reduces apoptotic signals. In a Schwann cell/dorsal root ganglion co-culture system, disruption of laminins impairs podia formation as well as the elongation of Schwann cells. These results demonstrate that: 1) laminins initiate axonal sorting and mediate axon-Schwann cell interactions …
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Diffuse axonal injury effect on myelinating cells and axons
… in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been shown to be myelinated by cortical oligodendrocytes in culture. An in vitro stretch injury model was used to analyze the DRG axon pathology during and after injury. DRG myelinating Schwann cells are …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
… and the guidance and survival of adult dorsal root ganglion neurons in a co-culture 3-D system.
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Molecular genetics of the imprinted gene - SPROUTY3 (SPRY3)
… in other ganglia in adults including retinal ganglion cells, dorsal root ganglion and superior cervical ganglion. SPRY3 enhancer can drive SPRY3 expression in the lung airway, which is consistent with a role in branching morphogenesis and the function of the original Drosophila Spry gene, …
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TIMP-1 as a Modulator of Inflammatory Pain
… found that transcriptomic alterations in the dorsal root ganglion (DRG) due to inflammation and deletion of TIMP-1 converge prominently on dysregulation of ion channel expression. This suggests that TIMP-1 regulates inflammatory pain by attenuating inflammation-induced upregulation of ion …
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A Multielectrode Microcompartment Platform for Signal Transduction in the Nervous System
… The electrophysiological activity of cultured dorsal root ganglion (DRG) neurons and cortical neurons is shown on the MEA substrate. These recordings were measured and tied to the toxicological effects of the chemotherapeutic drug vincristine on DRGs. Conventional electrophysiological …
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A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
… and anti-nociceptive factors regulating colonic dorsal root ganglion (DRG) neurons, which synapse onto second order dorsal horn neurons, are known to regulate chronic pain but the mechanisms are poorly understood. This thesis examined whether neuroanatomical remodeling of DRG central nerve …
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Restoring bladder function by promoting neuronal regeneration
Following dorsal root injury, dorsal root ganglion neurons can regenerate their severed axons but are unable to cross the dorsal root entry zone (DREZ) due to the presence of an inhibitory environment produced in part by chondroitin sulfate proteoglycans (CSPGs) manufactured by reactive astrocytes …
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Neural differentiation of pluripotent stem cells and applications to micropatterned agarose hydrogel for nerve guidance
… on the microchannels. Further studies using dorsal root ganglion (DRG) neurons, Schwann cells, and differentiating ES cells demonstrated good cell growth and nerve guidance through the micropatterned channels. Micropatterned hydrogels can be used as an in vitro model to replicate complex …
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Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
… calcium currents (VGCC) in small diameter dorsal root ganglion (DRG) neurons. Using behavioral, nerve-electrophysiology and patch-clamp methodology we examined the functional consequences of forced-exercise (treadmill, 5.4 km/week) on VGCC in dissociated small diameter DRG neurons from rats …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… sensory neurons. Using Ca2+-imaging of dorsal root ganglion (DRG) neurons, including neuron-enriched cultures generated by magnetic-activated cell sorting, I demonstrated that IL-17 directly activates capsaicin-sensitive DRG neurons in a phosphoinositide 3-kinase (PI3K)-dependent manner. …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
… TRPM3 protein expression in colon-projecting dorsal root ganglion (DRG) neurons and colonic nerve terminals, as well as functional activity at the neuronal and nerve levels. TRPM3 protein expression was observed in 76.1 % of colon-projecting DRG neurons and TRPM3 was also present in putative …
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