Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Dorsal Raphe Nucleus"”.
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The Effect of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Glucose Metabolism and Epileptogenesis in the Rat
<p>Anatomic connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the …
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Neuromedin U Acts via the Paraventricular Nucleus of the Hypothalamus and the Dorsal Raphe Nucleus to Regulate Motivation for High-Fat Food
… attributed to signaling in the paraventricular nucleus of the hypothalamus (PVN), NMU has also been found in other brain regions involved in both feeding behavior and motivation. We investigate the effects of NMU on motivation for food and food intake, and identify the brain regions mediating …
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The effects of intra-dorsal raphe administration of strychnine on rat behaviour and its interactions with ethanol
… serotonergic neurons which originate from the dorsal raphe nucleus. In addition, the serotonergic neurons of the dorsal raphe nucleus, which mediate the release of the neurotransmitter serotonin, have been implicated as a component of the neurocircuitry which underpins the generation of an …
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Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… network computations in the serotonergic dorsal raphe nucleus through a dynamical lens, exploring the role of short-term synaptic dynamics at sparse recurrent connections, and of distinct long-range synaptic inputs, in shaping the output of spiking populations. 1. Simulation-based …
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Characterization of genetically distinct neuronal subtypes in the lateral habenula using Cre mouse lines
… projects to the ventral tegmental area (VTA) and dorsal raphe nucleus (DNR), and is thus involved in both dopaminergic and serotonergic pathways. Recent single-cell transcriptomic profiling of the LHb has revealed that it consists of four neuronal subtypes that are localized into four subregions. …
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Targeted Disruption of the Deaf1 Gene in Mouse Brain and the Effects on Behavior and Gene Expression
… expression in the prefrontal cortex and the dorsal raphe nucleus of females but not males, and therefore may function in sex-specific depression. Standard (whole body) knockout of <italic>Deaf1</italic> has been reported to alter 5-hydroxytryptamine (serotonin) receptor 1A …
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Intermittent swim stress effects on anxiety behavior
… and noradrenergic neurons were assessed at the dorsal raphe nucleus and locus coeruleus, respectively, through immunohistochemistry techniques. Results indicated ISS-induced deficits were noted for social exploration, but not with the open field test. No apparent cellular differences were …
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… projections to the medial preoptic area (MPOA), dorsal raphe nucleus (DRN), and substantia nigra (SNR). Interestingly, transsynaptic retrograde tracing further demonstrated that these brain regions send projections to inguinal white adipose tissue (iWAT), suggesting potential ERαvlVMH-originated …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to assess the effects of the classic SSRI fluoxetine on 5-HT1A …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… conditioned place preference (CPP). Within the dorsal raphe nucleus (DRN), two overlapping populations of KOR-expressing neurons: Slc17a8 (VGluT3) and SERT, were distinguished functionally and anatomically. Optogenetic inhibition of these SERT+ neurons potentiated subsequent cocaine CPP, whereas …
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Regulation of dorsal raphe serotonergic neurons by histamine
… structures. Serotonergic neurons located in the dorsal raphe nucleus (DRN) are currently accepted to be wake-promoting however their precise regulation by other neurotransmitter systems during the sleep-wake cycle is currently unknown. The main aim of this study was to utilise in vitro and in …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
… striatal hyperinnervation by serotonergic dorsal raphe nucleus (DRN) axon terminals occurs following prolonged DA depletion. This dissertation tests the hypothesis that the serotonergic system is the major site where DA is synthesized from exogenous L-dopa in the DA-depleted rat.</p> <p>The …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… that GluR dysfunction may extend to the nucleus accumbens, a limbic area that is largely known as one of the “reward centers” in the brain and involved in the some of the rewarding and motivational aspects of motor impulsivity. We identified the vesicular glutamate transporter 3 (VGLUT3) …
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Aspects of tic like behaviour and serotonergic control
… on 5-HT single-unit activity recorded from the dorsal-raphe-nucleus in the behaving cat. Both drugs antagonised the suppression of unit activity caused by 8-0H DPAT. (S)-WA Y-100135 reduced unit activity whereas WAY-100635 increased it. This suggests that WAY-100635 is acting as an antagonist at …
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Sex Differences and the Role of the Serotonin System in Early Life Stress-Induced Ethanol-Motivated Behaviors in Adulthood
… drink to relieve negative affective states. The dorsal raphe nucleus (DRN)-serotonin (5-HT) system has an important role in mood regulation, is sexually dimorphic, vulnerable to stress-induced perturbations during development, and shows an inverse relationship with ethanol (EtOH) consumption. …
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Dissection of Neurons and Circuits Involved in Regulating Innate Behaviors, Movement and Higher Cognitive Functions in Mice
… and in particular on the role of the Subthalamic Nucleus (STN) in Parkinson's Disease and Obsessive-Compulsive Disorder. I identified previously undescribed subpopulations of STN neurons, and tested their role in mediating motor, emotional and cognitive functions in mice, both in normal and …
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Dissecting the Functional Heterogeneity of Serotonergic Systems That Regulate Fear and Panic
… that the amygdala-projecting neurons from dorsal Raphe (DR) were almost exclusively serotonergic (92-95%) concen-trated in the dorsal/ventral (DRD/DRV) DR, with few non-serotonergic neurons. While selective lesioning of this network with saporin toxin (SAP) facilitated the extinction of …
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Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat
… of the nigrostriatal dopaminergic (DA) and raphe striatal serotonergic (5-HT) systems. The movement impairments including rigidity of the hind limbs, a staggering gait, a tendency to fall over every few steps, a slight whole body tremor and difficulty in initiating movements. The dysfunction …