NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 27 for “"Dorsal Hippocampus"”.

  1. Examining cholinergic fuction in the ventral tegmental area and dorsal hippocampus

    Fullerton, Josephine L.University of Strathclyde2017

    … from the pedunculopontine tegmental and laterodorsal tegmental nuclei (PPTg, LDTg). Previous studies have shown that selective bilateral cholinergic lesions of the posterior PPTg or LDTg can be achieved by directly infusing diphtheria-urotensin II toxin (Dtx-UII) into either region. This thesis …

    strathclyde Repository record

  2. Peripubertal Binge Ethanol, Age and Sex Modulate Microrna Expression in the Ventral and Dorsal Hippocampus of the Adolescent Rat

    Prins, Sarah Arianne2016

    … are differentially expressed in the ventral hippocampus dependent on age and 17&beta;-estradiol (E<sub>2</sub>). We examine whether microRNA expression, microRNA biogenesis enzymes Drosha and Dicer, and microRNA target genes BDNF and SIRT1 are altered by peripubertal binge EtOH in the ventral …

    loyola-thes Repository record

  3. The Effect of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Glucose Metabolism and Epileptogenesis in the Rat

    Douglas, Clifford C.

    <p>Anatomic connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the …

    loma-linda Repository record

  4. The use of lentivirus-mediated gene delivery to investigate the role of the Brain specific transcription factor MYT1L In-vitro and In-vivo

    Martinez Medina, LourdesKing's College London2014

    … of lentiviruses expressing Myt1l shRNAmir in the dorsal hippocampus. These mice manifested a very subtle and transient increase in anxiety-like behaviour, which normalised with time. Even though the dorsal hippocampus has been only weakly linked to anxiety, our results seem to support this …

    kings Repository record

  5. Repurposing BT-11 to Treat Alzheimer’s Disease: Exploring the Glutathione-s-transferase LANCL2 as a Target

    Birnbaum, EmilyThe Graduate School and University Center of The City University of New York2024

    … well as Aβ plaque load and neuronal loss in the dorsal hippocampus of TgF344-AD male rats compared to WT rats. While these effects were not observed in female TgF344-AD rats, BT-11 treatment mitigated microglia numbers in the dorsal hippocampus of TgF344-AD female rats compared to WT rats.</p> …

    cuny-grad Repository record

  6. The Role of Membrane-Bound Receptors in the Rapid Estrogenic Enhancements of Learning and Memory Within the Hippocampus

    Kuun, TalyaUniversity of Guelph2021

    … administration. Studies have identified the dorsal hippocampus as one site of these estrogenic enhancing effects. Whether these rapid estrogenic effects are mediated solely by membrane-bound estrogen receptors is currently unknown. This study sought to determine the role of membrane estrogen …

    guelph Repository record

  7. Antagonizing Dorsal Hippocampal Dopamine D1-type Receptors Affects Social Learning and Social Interactions but not Food Intake in Male and Female Mice

    Matta, RichardUniversity of Guelph2014

    … area has dopaminergic projections to the hippocampus—a site important for social learning in the STFP. In this study, we microinfused the DA D1-type receptor antagonist SCH23390 into the dorsal hippocampus of adult male and female mice. We found that SCH23390 blocked social learning in …

    guelph Repository record

  8. Investigating the Role of Dopamine D1 Receptor Activation in Overcoming Boundary Conditions for Object Identity and Object Location Memory Malleability

    O'Neill, OliviaUniversity of Guelph2024

    … on the D1R activity in the perirhinal cortex and dorsal hippocampus, respectively. The present thesis suggests an important role for dopamine in overriding boundary conditions for destabilization and subsequent updating of declarative-like memories.

    guelph Repository record

  9. Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice

    Andrec, Katherine Emily2026

    … in adulthood, resulting in altered hippocampus-dependent cognition and plasticity. Despite the critical role of synapse organizers in development, the effects of Mdga2 reduction on synaptogenesis, synaptic pruning, and long-term depression (LTD) remain unclear. To address this gap, …

    york Repository record

  10. A Behavioural, Molecular and Lesion Examination of Hippocampal Contributions to Morris Water Maze Acquisition

    Diviney, MaireadNational University of Ireland Maynooth2011

    … It has also been well documented that the hippocampus is a critical structure in the processing of allocentric representations. However, there has been debate surrounding the exact nature of this involvement, with suggestions that hippocampal damage leads to deficiencies in navigational …

    maynooth Repository record

  11. Hippocampal Output to the Septum Regulates Locomotion and Exploration

    Chen, Yuh-Tarng2024

    The cognitive maps are established in the dorsal hippocampus (DH) when the animal explores the environment. During exploration, the DH combined extrinsic inputs from multiple sensory and motor-related structures to generate locomotion-dependent activity; however, the hippocampal mechanisms of …

    utswmed Repository record

  12. EXAMINING SEX DIFFERENCES IN NEUROBIOLOGICAL AND BEHAVIORAL CHANGES INDUCED BY CHRONIC INTERMITTENT ETHANOL VAPOR EXPOSURE IN LONG EVANS RATS

    Morgan, JamesWake Forest University2018

    … largely restricted to the ventral domain of the hippocampus (VHC). Although relatively few studies have examined the effects of CIE in females, emerging evidence suggests that they may be less sensitive to CIE treatment. Here we sought to test the hypotheses that CIE would have less effect on …

    wfu Repository record

  13. ACUTE NICOTINE-DEPENDENT ALTERATIONS IN ASSOCIATIVE LEARNING INTERFERE WITH BACKWARDS TRACE CONDITIONED SAFETY

    Connor, David A.Temple University. Libraries2016

    … to modulate associative learning, including hippocampus-dependent forms of fear learning, we hypothesized that nicotine administration could cause maladaptive associative learning to occur, leading to altered safety learning. In the present study, mice were administered acute nicotine and …

    temple Repository record

  14. ANALYSIS OF ADULT NEUROGENESIS AND HIPPOCAMPUS-DEPENDENT MEMORY IN MOUSE MODELS FOR AGING, ALZHEIMER’S DISEASE AND CRANIAL IRRADIATION-INDUCED NEUROINFLAMMATION

    Cortez, IbdaneloThe University of Texas Medical Branch at Galveston2021

    … in neurodegeneration models. Briefly, the hippocampus is responsible for encoding long-term memories associated with spatial and contextual cognitive tasks and is susceptible to AD pathology. The hippocampus is one of the few areas in the adult brain where new neurons are continuously …

    utmb Repository record

  15. Physiological Effects of Estradiol in the Mouse Hippocampal Formation

    Spencer, Joanna L

    … brain-derived neurotrophic factor (BDNF), in the dorsal hippocampus of female mice. In naturally cycling and ovariectomized female mice, estradiol increased hippocampal Akt and BDNF signaling as determined by immunocytochemistry and in situ hybridization. These effects were associated with changes …

    rockefeller Repository record

  16. Cell Type Specific Roles of Serotonin Receptor 4 in the Hippocampus and Neocortex in Emotion and Cognition

    Karayol, Remzi

    … in genetically defined cell types of the hippocampus and neocortex, two regions highly implicated in emotive and cognitive function, I generated a novel Cre-dependent Htr4 knockout mouse line. Intriguingly, the loss of functional 5-HT<sub>4</sub>R specifically in the mature excitatory …

    rockefeller Repository record

  17. Molecular alterations of AMPA receptors and their effects on hippocampus dependent tasks

    Marx, VerenaUniversität Heidelberg

    … mediated behavioral function using several hippocampus dependent behavioral tasks, ranging from neophobia to spatial reference memory, in a variety of genetically modified mice. Studies using GluR-A knock-out (GluR-A-/-) mice showed that GluR-A containing AMPA receptors are required for …

    heid-diss Repository record

  18. Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome

    Stringer, Megan Elizabeth2015

    … thought to depend on distinctive encoding in the hippocampus. Pattern separation has been linked to functional activity of newly generated granule cells in the dentate gyrus. Recent studies in Ts65Dn mice have reported significant reductions in adult hippocampal neurogenesis, and after EGCG …

    iupui Repository record

  19. Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.

    CAMOGLIO, CHIARAUniversità degli Studi di Cagliari2024

    … GPX1, GPX4) in the prefrontal cortex (PFC) and dorsal hippocampus (dHPC) of female rats subjected to the activity-based anorexia (ABA) paradigm, a model which combines a restricted feeding schedule with unlimited access to a running wheel to successfully reproduce the severe weight loss and …

    cagliari Repository record

  20. Glutamate and MDMA Neurobehavioral Toxicity

    Anneken, John H.University of Cincinnati2012

    … concentration of extracellular glutamate in the dorsal hippocampus. Furthermore, this increase was not observed in either the prefrontal cortex or the striatum. Direct infusion of MDMA to the hippocampus evoked a similar increase, suggesting a local, intrahippocampal site of action of the drug. …

    ohiolink Repository record

Page 1 of 2