Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"Dopaminergic neurons"”.
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Degenerative mechanism in dopaminergic neurons
The degenerative mechanisms of dopaminergic cells in Parkinsona??s disease (PD) remained elusive even after many years of research. However, many have hypothesized that the cell deaths in PD are via apoptosis and in particularly, by the mitochondrial-mediated apoptotic pathway. As such, the purpose …
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Seasonal plasticity of A15 dopaminergic neurons in the ewe
… to E2 negative feedback that is mediated by A15 dopaminergic neurons that are only responsive to E2 in anestrus. Experiment 1, tested the hypothesis that synaptic input on A15 neurons varies with season by examining synapsin-positive close contacts on A15 cells using immunofluorescence and …
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Representations of Reward and Movement in Drosophila Dopaminergic Neurons
… this dual role of dopamine involves the same dopaminergic pathways. Although reward-responsive dopaminergic neurons display movement-related activity, debate continues as to what features of an individual's experience these motor-correlates correspond and how they influence concurrent …
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Identification and characterization of genes expressed by the midbrain dopaminergic neurons
The midbrain dopaminergic (mDA) neurons are the main source of dopamine in the brain. The goal of this study was to identify and characterize genes effective during the intermediate period between induction and full differentiation of the mDA neurons. The generation of En chimeric animals permitted …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
… discovered to become activated in sympathetic neurons in response to oxidative stress induced by 4-hydroxynonenal (HNE) in a ligand-independent mechanism. Furthermore, cleavage of the receptor was demonstrated to contribute to the death of sympathetic neurons following oxidative insult. This …
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INVESTIGATION OF ALPHA-SYNUCLEIN/TUBULIN INTERACTION IN PRESYNAPTIC MICROTUBULE DYNAMICS IN DOPAMINERGIC NEURONS
… underlying the degeneration and loss of the dopaminergic (DA) neurons of the substantia nigra pars compacta (SNpc) in Parkinson’s disease (PD) are still unknown. Among them, α-synuclein aggregation, mitochondrial impairment, increase oxidative stress and synaptic dysfunction are often …
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Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area
… brain regions implicated in the reward pathway. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain are activated by nicotine and form the natural reward pathway that is known to contribute to addiction. In recent years, microRNAs (miRNAs) have been found to …
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The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes
Dysfunction of cholinergic and dopaminergic systems has been implicated in memory function de cits that are core pathology and associated features of several neurological disorders. However, in order to develop more effective treatments, it is crucial to better understand how different aspects of …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
… axons. To create an in vitro model of PD, dopaminergic axons from midbrain cultures were isolated within the microchannels away from the cell bodies. To determine the best method for imaging intracellular organelles, cells were transduced with a mitochondria targeted DsRed2 lentiviral …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. Clinical trials have …
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Engrailed genes are cell autonomously required for the survival of the mesencephalic dopaminergic neurons
The dopaminergic neurons of the substantia nigra and ventral tegmentum are the main source of dopamine in the central nervous system. The progressive loss of dopaminergic neurons in the substantia nigra compacta over several decades leads to one of the most prominent human neurodegenerative …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (SN). Numerous studies have provided evidence suggesting that neuroinflammation plays a critical role in the pathogenesis of PD. The present study was to evaluate effect of human bone marrow-derived …
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Prolactin Effects on Nigrostriatal and Mesolimbic Dopaminergic Neurons: In Vivo and In Vitro Studies
… of prolactin on nigrostriatal and mesolimbic dopaminergic neuronal activity and its possible regulatory mechanism were examined.
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… disorder characterized by a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A number of studies have implicated chronic inflammation in the pathophysiology of PD; however, it is unclear which inflammatory mechanisms directly contribute to neuronal loss …
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Human Embryonic stem cell-derived A9 dopaminergic neurons as a model and therapy for Parkinson's disease
… reliably generate standardised populations of A9 dopaminergic neurons. For this reason, they are an ideal candidate cell source for both cell therapies and drug screening platforms for PD. A hallmark pathology of PD involves the atypical aggregation of alpha synuclein and subsequent formation of …
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Parkinson's Disease-Associated Protein VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human iPSC-Derived Dopaminergic Neurons
… of VPS13C in Parkinson’s disease-relevant human dopaminergic neurons has not yet been investigated. This thesis established a PD-relevant model using human induced pluripotent stem cell-derived dopaminergic neurons and identified an important role for VPS13C in lysosomal homeostasis. …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
Progressive loss of mesencephalic dopaminergic (mesDA) neurons is the main pathological feature of Prakinson’s Disease. The homeobox transcription factors, Engrailed-1 and Engrailed-2, are essential for survival and long-term maintenance of this neuronal population. In mutant embryos, null for both …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… This is caused by progressive degeneration of dopaminergic neurons (DNs) in the midbrain (substantia nigra pars compacta), which innervate the striatum. Although initially efficacious, the therapeutic effect of various anti-parkinsonian pharmacological treatments is limited to five to ten …
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Transplantation of Mouse Embryonic Stem Cell-Derived Dopaminergic Neurons in a Unilateral 6-Hydroxydopamine Lesion Rat Model of Parkinson’s Disease
Embryonale Stammzellen (ES Zellen) sind eine vielversprechende Möglichkeit für Zellenerzatztherapie der Parkinson-Erkrankung. Undifferenzierte ES Zellen der Maus differenzieren sich zu funktionellen dopaminergen Neuronen nach der Transplantation in ein experimentellen Rattenmodell der …
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