Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Dopaminergic neuron"”.
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Tumor Necrosis Factor Dependent Mechanisms and Neuroprotective Strategies in Models of Parkinson's Disease
… disorder characterized by the loss of dopaminergic neurons in the substantia nigra that innervate the striatum. Although the nigral cell loss that causes motor dysfunction in Parkinson's disease has been identified for some time, the mechanisms that lead to this dopaminergic neuron loss …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… disorder characterized by a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A number of studies have implicated chronic inflammation in the pathophysiology of PD; however, it is unclear which inflammatory mechanisms directly contribute to neuronal loss …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… the fates of oligodendrocytes and motor neurons as well as proliferation of neural precursors and control of axon outgrowth. To explore the roles of Shh in neuronal differentiation, we utilized embryonal carcinomal P19 cells as an in vitro model system. We overexpressed Shh in P19 cells …
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Uncovering the Importance of Cell Morphology, Genetic Regulation, and Neuronal Signalling in Quiescent Neural Stem Cells
… are essential for their ability to produce new neurons during neurogenesis. These cells undergo quiescence, the state when quiescent cells are metabolically active but do not produce new neurons. Understanding and manipulating this critical state is essential due to undiscovered applications in …
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Microbiome-Brain interactions in Parkinson’s neurodegeneration: The effect of microbiota modulation in a PINK1 mutant Drosophila melanogaster model of Parkinson’s disease
… locomotor ability, mitochondrial function, dopaminergic neuron markers and microbiota composition changes were observed. After microbiota modulation, lifespan records showed significant alterations between the groups with enhanced viability induced by E. cloacae and E. coli in both W1118 and …
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Surprising Behavioral and Neurochemical Enhancements in Mice with Combined Mutations Linked to Parkinson's Disease
… causes progressive death of dopamine-producing neurons in the substrantia nigra and depleted dopamine in the striatum. Loss of striatal dopamine results in locomotor symptoms such as bradykinesia, tremor, rigidity and postural instability. Although most forms of the disease are spontaneous, a …
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H5N1 Influenza Virus Induces a Parkinsonian Pathology
… compacta (SNpc) tyrosine hydroxylase positive dopaminergic neuron number and striatal dopamine and its metabolites contents through 90 days post infection (dpi), 2) examined the inflammatory effect of infection by quantitatively measuring the total number of resting and activated microglia in …
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Adaptive optics stimulated emission depletion microscope for thick sample imaging
… thick, aberrating samples. HeLa, RPE-1 cells and dopaminergic neuron differentiated from human IPS cells were imaged using the microscope. The results shown in this thesis present 3D STED imaging of thick biological samples and, what is particularly worth to highlight, 3D STED imaging at the 80μm …
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Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins
… disease characterized by a loss of dopaminergic neurons in the substantia nigra. The cause of Parkinson’s disease remains uncertain, however, evidence implicates mitochondrial dysfunction and oxidative stress with selective vulnerability of dopaminergic neurons. Although most cases …
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Dopaminergic Modulation Shapes Sensorimotor Processing in the Drosophila Mushroom Body
… structure essential for olfactory learning. Dopaminergic neurons convey salient information about reward and punishment to the mushroom body in order to adjust synaptic connectivity between Kenyon cells, the neurons representing olfactory stimuli, and the mushroom body output neurons that …
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Identification and characterization of retinoic acid-induced morphological and electrophysiological changes in an invertebrate nervous system
… RA. For example, recent work utilizing cultured neurons from the pond snaa Lymnaea stagnalis, has shown that RA can elicit a regenerative response, growth cone turning, independently of "classical" transcriptional activation While this work illustrates a novel regeneration-inducing effect in …
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Human Embryonic stem cell-derived A9 dopaminergic neurons as a model and therapy for Parkinson's disease
… reliably generate standardised populations of A9 dopaminergic neurons. For this reason, they are an ideal candidate cell source for both cell therapies and drug screening platforms for PD. A hallmark pathology of PD involves the atypical aggregation of alpha synuclein and subsequent formation of …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… levels are increased in substantia nigra (SN) dopaminergic neurons, causing cell death. Current PD and DLB treatments are symptomatic and do not target the disease at its source or prevent its progression.<br/>In order to develop protective treatments for PD and DLB, it is important to first …
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
… to be a trophic factor for embryonic midbrain dopaminergic neurons in vitro (Krieglstein et al. 1995) and after transplantation to adult rats in vivo (Sullivan et al. 1998). GDF-5 has also been shown to have neuroprotective and neurorestorative effects on adult dopaminergic neurons in the …
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Derivation of next generation research models of Parkinson’s disease
… PD is characterized by the degeneration of dopaminergic neurons in the substantia nigra region of the midbrain and the presence of intracellular inclusions, notably Lewy bodies composed of the alpha-synuclein protein (encoded by the SNCA gene), in the surviving neurons. The precise molecular …
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Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia
… process. Microglia may directly toxic to neurons by releasing various substances such as inflammatory cytokines. Thus, it is pathophysiologically important to understand how the extent and duration of brain inflammation is controlled in vivo. In addition to down-regulation of inflammatory …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
… cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry. This in vivo and in vitro effect was ameliorated by the TRPV1 antagonist capsazepine (CZP) or iodo-resiniferatoxin (I-RTX), suggesting the direct involvement of TRPV1 in neurotoxicity. …