Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Dopaminergic cells"”.
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Effects of Central and Peripheral Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (Mptp) in the Rat and Mouse
… is taken up by monamine oxidase containing glial cells and converted to its neurotoxic form N-methyl-4-phenyl pyridinium ion (MPP+), and 2), this is followed by uptake of MPP+ by dopaminergic cells via an uptake system. The above two steps are necessary for the neurotoxicity of MPTP to be …
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Degenerative mechanism in dopaminergic neurons
The degenerative mechanisms of dopaminergic cells in Parkinsona??s disease (PD) remained elusive even after many years of research. However, many have hypothesized that the cell deaths in PD are via apoptosis and in particularly, by the mitochondrial-mediated apoptotic pathway. As such, the purpose …
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Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat
… and progressive dysfunction of the nigrostriatal dopaminergic (DA) and raphe striatal serotonergic (5-HT) systems. The movement impairments including rigidity of the hind limbs, a staggering gait, a tendency to fall over every few steps, a slight whole body tremor and difficulty in initiating …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… of PD, characterised by progressive loss of dopaminergic neurones in the substantia nigra, have linked α-synuclein toxicity and oxidative stress to the pathogenesis of the disorder. Interestingly HDAC-Is have been shown to prevent α-synuclein and 1-methyl-4-phenylpyridinium (MPP+)-induced …
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Role of basic fibroblast growth factor in the development of sensitization to the effects of amphetamine
… in its effects on locomotor activity, reward and dopaminergic function. The precise mechanisms responsible for this persistent drug-induced sensitization are unknown, but evidence suggests that neuroadaptations initiated in the cell body region of midbrain dopaminergic neurons and dependent on …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… is expressed in microglia and peripheral immune cells, where it is involved in macrophages polarization and in the control of inflammatory responses, by modulating gene transcription. Several studies have shown that PPARγ agonists are neuroprotective in experimental PD models in rodents and …
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Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… maternal behaviors, and increase the level of dopaminergic cells in the ventral tegmental area in offspring reared by Low LG dams to the level of those reared by High LG dams. This finding suggests that ERalpha is a mediating factor for the effect of maternal LG on offspring maternal behavior. …
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In vivo and in vitro approaches to characterising axon growth and metabolic alterations in Parkinson’s disease
… that at the time of disease onset, midbrain dopaminergic cells lose their synaptic connectivity before dying. The preposition that dopaminergic axons degenerate initially and predominantly in PD offers new critical opportunities for the development of neuroprotective and restorative …
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Exploring neuro-immune interactions in neurodegeneration: the role of B lymphocytes in Parkinson’s disease
… on the contribution of B lymphocytes. These cells play a number of roles including antibody production, maintenance of subcapsular sinus macrophages, antigen presentation and regulation of T cell activity. Methods: I phenotyped peripheral blood B lymphocytes in 3 clinical cohorts and …
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Towards Gene Therapy of Parkinson’s Disease: Implantation of RUC-GDNF Secreting Mammalian Cell Lines into Rat Brain
… for monitoring the function of implanted cells by a Renilla luciferase -glial cell line derived neurotrophic factor (RUC-GDNF) fusion protein in CSF. The RUC-GDNF protein is expected to report GDNF secreted from the cell by bioluminescence through luciferase activity.</p> <p>Current <em>ex …
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Identification and characterization of retinoic acid-induced morphological and electrophysiological changes in an invertebrate nervous system
… in situ approach focusing on a single identified dopaminergic neuron which possesses a known "mapped" morphology within the CNS. These studies show, for the first time in an invertebrate, that RA can increase neurite outgrowth of dopaminergic cells that have undergone a nerve-crush injury. …