Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Dopamine receptor"”.
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these receptors as well. Studies on dopamine receptors in the cardiovascular system …
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Synthesis and Evaluation of Tetrahydroprotoberberines as Dopamine Receptor Ligands
<p>Dopamine (DA) receptors belong to the G-protein coupled receptors (GPCRs) family, divided in to two groups based on their high homology transmembrane domains; D1-like DA receptors (D1, D5) and D2-like DA receptors (D2-D4). DA receptor specific ligands have been exploited as a means for studying …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… and relapse, possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this hypothesis, our initial studies measured alterations in cAMP-dependent and -independent protein phosphorylation in vivo produced by chronic cocaine and heroin …
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Alterations of central dopamine receptor sensitivity in the spontaneously hypertensive rat
… have indicated possible abnormalities in the dopaminergic systems of SHR. Therefore the present study was undertaken to examine more closely the sensitivity of SHR to stimulation of their dopamine (DA) receptors.
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Isopeptide and Ester Bond Ubiquitination Regulate Degradation of the Human Dopamine Receptor 4
<p>The human dopamine receptor 4 (hD4R) is a seven-transmembrane helical G protein-coupled receptor (GPCR) found in neural synaptic membranes. The neurotransmitter dopamine binds to and activates the hD4R, which is involved in central nervous system pathways that modulate cognition and circadian …
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
… as it functions as an antagonist at cannabinoid receptor 1 (CB1). However, recent evidence suggests that CBD may also be a CB1 negative allosteric modulator of (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC). Interestingly, the ECS is linked to the main circuit thought to modulate reward signaling …
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Altered Decision Behavior of Dopamine Receptor Knock-out Mice in a Free Binary Choice Task
Dopamine has been thought to play an important role in updating values according to reward prediction error by reinforcement learning theory, since the finding that phasic activity of midbrain dopamine neurons signals the difference between actual and predicted outcomes (reward prediction error). …
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D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line
<p>Bromocriptine, a D2 dopamine receptor (D2R) agonist, is used clinically as a treatment for pituitary tumors of a lactotroph origin. Many questions remain unanswered about the mechanism of this effect. The antiproliferative effect has not been demonstrated in DMS 53 cell line, a Small Cell Lung …
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Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
Mouse models of Huntington's Disease (HD) are often used for testing potential therapeutic compounds. These experiments require substantial investments in time and resources, and have yet to produce any intervention that has made a significant impact on disease progression in the clinic. In …
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Associations of Single Nucleotide Polymorphisms in the Bovine Prolactin, Melatonin Receptor 1A, and Dopamine Receptor D2 Genes with Hair Coat Shedding Scores and Productivity Traits in Beef Cattle
… associated with reproductive traits, melatonin receptor 1a (MTNR1A) has been associated with meat quality traits, and the dopamine receptor D2 (DRD2) gene has been associated with hair coat score (HCS) in cattle. Our objective was to determine associations between mutations in the PRL, MTNR1A, …
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Study of the Role of the Bed Nucleus of the Stria Termialis D1- and D2-Like Dopamine Receptors in Cocaine Self-Administering Rats
… reciprocal projections from the BST to various dopamine rich areas (ventral tegmental area (VTA), nucleus accumbens shell (NAc shell), retrorubral nucleus (RR), periaqueductal gray region (PAG)), BST dopamine receptors are indeed an important part of the highly integrated reward system and thus …
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Ethanol priming and its effects on consumption and accumbal plasticity
… aspects of drug responding and have distinct dopamine responses. The accumbens can be further divided into two subpopulations of D1-dopamine receptor (D1) or D2-dopamine receptor (D2) expressing medium spiny neurons (MSNs) that precipitate different intracellular cascades and actions upon the …
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Behavioural assays of the effects of antidepressant drug treatment on the functioning of catecholamine systems
… drugs on central beta-adrenergic and dopaminergic receptor function were investigated using the anorexic effects of low doses of amphetamine and apomorphine as assays of beta-adrenergic function and presynaptic dopamine function respectively. Anorexia was typically examined using a …
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Dopaminergic Genetic Contributions to Obesity in Kidney Transplant Recipients
… experienced by kidney transplant recipients. Dopamine is a neurotransmitter that has previously been implicated in substance addiction. Recently, neuroimaging and neurogenetic data have shown that dopamine may also play a role in obesity. Both dopamine receptor genes and genes related to …
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Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward
… circadian genes are expressed is the mesolimbic dopaminergic pathway, containing brain regions such as the Nucleus Accumbens(NAc) and the Caudate Putamen (CP), among others. We set out to investigate how repeated cocaine exposure regulates core clock circadian genes in striatal regions and …
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The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model
… to characterize the role of CLOCK in regulating dopamine transmission in mood and reward-related circuits. We present a mechanism by which CLOCK regulates dopaminergic activity in the mesoaccumbens circuit and contributes to anxiety-related behavior. In vivo recording of ventral tegmental area …
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