Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Dopamine Receptors"”.
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The G protein-coupling specificity of D2-like dopamine receptors
The G-protein coupling specificity of D2-like dopamine receptors was investigated using both receptor-G protein fusions and membranes of cells in which pertussis toxin-resistant mutants of individual Gi-family G proteins could be expressed in an inducible fashion. A range of ligands displayed …
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Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors
… of ligands for Central Nervous System (CNS) receptors. Previous research indicates that the aporphine scaffold may be manipulated to synthesize selective ligands for serotonin and dopamine receptors. Novel aporphine alkaloids containing C10 nitrogen substitutions were synthesized, and their …
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Study of the Role of the Bed Nucleus of the Stria Termialis D1- and D2-Like Dopamine Receptors in Cocaine Self-Administering Rats
… reciprocal projections from the BST to various dopamine rich areas (ventral tegmental area (VTA), nucleus accumbens shell (NAc shell), retrorubral nucleus (RR), periaqueductal gray region (PAG)), BST dopamine receptors are indeed an important part of the highly integrated reward system and thus …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these receptors as well. Studies on dopamine receptors in the cardiovascular system …
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BIOLOGICAL AND ENVIRONMENTAL PREDICTORS OF EXTERNALIZING BEHAVIOR IN LATE CHILDHOOD AND ADOLESCENCE: A TWIN STUDY
… delinquent peers and siblings, and specific dopamine receptors on the development of externalizing behavior in children and adolescents, along with the role of heritability in aggression and delinquency. Specifically, it was hypothesized that increased birth complications, presence of …
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Automated, highly scalable RNA-seq analysis
… long-standing debate regarding the expression of dopamine receptors in the superior colliculus and found a striking segregation of the Drd1 and Drd2 dopamine receptors into distinct functional zones.
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Cognitive Effects of Estrogens During Aging
… neurochemical mechanisms, densities of D1 and D2 dopamine receptors and dopamine transporter (DAT) were measured in the prefrontal cortex of genistein-treated rats by Western blot. D1 and D2 densities did not differ between groups. However, DAT density was lower in the control group relative to …
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Behavioural assays of the effects of antidepressant drug treatment on the functioning of catecholamine systems
… drugs on central beta-adrenergic and dopaminergic receptor function were investigated using the anorexic effects of low doses of amphetamine and apomorphine as assays of beta-adrenergic function and presynaptic dopamine function respectively. Anorexia was typically examined using a …
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Unravelling the D1R-D2R heteromer
<p>Dopamine receptors D1R and D2R form a heterooligomeric complex with signaling properties distinct from the individual receptors. Aberrant expression of this protein-protein complex is linked to the etiology of various neuropsychiatric diseases. Formation of the D1R-D2R heteromer is thought to be …
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Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors
Dopamine receptors mediate various important neurophysiological functions. At a molecular level, G protein coupling is considered the main activation mechanism for most of the receptor-mediated cellular processes. A number of studies using native tissue have supported the idea that receptors can …
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Dopamine and the Temporal Dependence of Learning and Memory
… how the relative timing of olfactory inputs and dopaminergic reinforcement signals is encoded at the molecular, synaptic, and circuit level to give rise to learned odor associations. I show that in Drosophila, opposing olfactory associations can be formed and updated on a trial-by-trial basis …
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Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
… cause of schizophrenia was focused on elevated dopamine levels found in critical areas of the brain. Recently a new theory has emerged pointing to elevated glutamate levels resulting from hypofunction of NMDA receptors and hypoactivity of GABAergic neurons which normally inhibit glutamatergic …
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EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS
… of schizophrenia may come from overexpression of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking …
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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
… mechanism of cocaine in addiction is to inhibit dopamine re-uptake and glutamate is an excitatory neurotransmitter involved in addiction. Previous studies have demonstrated a link between phospholipase D (PLD) and metabotropic glutamate receptors (mGluRs), while other studies show an interaction …
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Linking dopaminergic physiology to working memory related neural circuitry
… in the disease. At the biophysical level, NMDA receptors and dopamine receptors have been continually implicated in supporting persistent activity during spatial working memory. Perhaps relatedly, drugs that target the dopamine system are regularly used in the treatment of schizophrenia, and …
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Dopaminergic modulation of basolateral amygdala for fear extinction
… Recently work has identified a population of VTA dopamine neurons that signal shock omission during extinction, but a downstream target for that activity hasn’t been identified. In this thesis, I demonstrate the role of dopamine signaling in driving fear extinction in distinct BLA neuronal …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… can affect the electrical activity of dopamine neurons in the ventral tegmental area (VTA) and of pyramidal neurons in the prefrontal cortex (PFC), using single-unit activity recording techniques. We have also investigated, whether these peptides can alter some dopamine-dependent …
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Molecular Signaling and Agonist Discovery for GPR52
… driven by Gs. GPR52 is co-expressed with D2 dopamine receptors, and in vitro studies show crosstalk at the level of adenylyl cyclase and cAMP signaling. The constitutive activity of GPR52 allows for more dynamic modulation of cAMP by D2R ligands and additionally sets a threshold for maximal …
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Lentiviral-mediated gene delivery to investigate the functional role of neuropsychiatric genes
… neuropsychiatric disorders. For example, dopamine receptor genes are established candidates for a number of psychiatric disorders such as Parkinson’s Disease, alcohol addiction and mood disorders. On the other hand, a gene of unknown function, AUTS2 (Autism susceptibility candidate 2), has …
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Modeling and Mapping Addiction in the Zebrafish, Danio rerio
<p>Driven by the communication of dopamine, the vertebrate reward system has been evolutionarily conserved to maintain survival and optimize fitness. The neural circuits governing this system integrate sensory stimuli to produce appropriate, self-preserving responses that underlie experience-based …
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