Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Dopamine D2 receptor"”.
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RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
Dysregulated D2R expression and function is implicated in the pathophysiology of many diseases including Parkinson’s disease, schizophrenia, and drug addiction. D2R trafficking is vital to proper D2R function. While the expression and activity of D2Rs are altered in the pathology of these diseases, …
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Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors.
… past work, we have shown neonatal quinpirole (dopamine D<sub>2</sub>/D<sub>3</sub> agonist) treatment produces a significant increase in dopamine D<sub>2</sub> receptor sensitivity, a phenomenon known as D<sub>2</sub> receptor priming. Dopamine D<sub>2</sub> receptor priming is common in …
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Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes.
… on locomotor hyperactivity in an animal model of D2-priming, and whether conditioned hyperactivity could be blocked by the D2 antagonist eticlopride or the D3 antagonist nafadotride. D2-primed male rats showed enhanced nicotine sensitization as evidenced by statistically significant differences in …
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Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
… is implicated in the regulation of the 5-HT1A receptor and is genetically linked to non-syndromic mental retardation. Initially, I have characterized the repressor activity of a novel long isoform of human Freud-1 and shown that it is the major isoform expressed in human cells, and that it …
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FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
G protein-coupled receptors (GPCRs) are drug targets that often activate multiple signaling pathways. The multiple GPCR responses provide opportunities for biased or functionally selective ligands to preferentially modulate one signaling pathway over another. Studies with several GPCRs have …
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The G protein-coupling specificity of D2-like dopamine receptors
The G-protein coupling specificity of D2-like dopamine receptors was investigated using both receptor-G protein fusions and membranes of cells in which pertussis toxin-resistant mutants of individual Gi-family G proteins could be expressed in an inducible fashion. A range of ligands displayed …
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Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.
… light of the putative role of the serotonergic, dopaminergic and possibly (nor)adrenergic system in OCD, following polymorphisms were analysed in a sample of >100 OCD patients and a control sample of >100 ethnically matched Caucasian subjects by means of a case-control study: Taq IA polymorphism …
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The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis
… A hallmark of the disorder is increased dopamine D2 receptor sensitivity in the brain. Studies have shown that schizophrenics smoke cigarettes at approximately 4 times the rate of the general population. It has been suggested that nicotine use is a form of self-medication for symptoms in …
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Associations of Single Nucleotide Polymorphisms in the Bovine Prolactin, Melatonin Receptor 1A, and Dopamine Receptor D2 Genes with Hair Coat Shedding Scores and Productivity Traits in Beef Cattle
… associated with reproductive traits, melatonin receptor 1a (MTNR1A) has been associated with meat quality traits, and the dopamine receptor D2 (DRD2) gene has been associated with hair coat score (HCS) in cattle. Our objective was to determine associations between mutations in the PRL, MTNR1A, …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… interleukine-1β (IL-1β), serotonin (5-HT) receptor subtypes, and dopamine D2 receptors in the brainstem and cerebellum, as well as to elucidate the role of peripheral MCP-1 in cancer chemotherapy 5-flouracil (5FU)-induced changes in these CNS fatigue-related neural factors. Methods: Male …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
… di massa, mRNA di elementi del sistema EC e dopaminergico (DA), mediante reazione quantitativa a catena della polimerasi in tempo reale, 3) espressione proteica di elementi del sistema EC, mediante analisi western blot, 4) meccanismi epigenetici: metilazione del DNA a livello di regioni …