Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Dopamine D2"”.
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Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes.
… on locomotor hyperactivity in an animal model of D2-priming, and whether conditioned hyperactivity could be blocked by the D2 antagonist eticlopride or the D3 antagonist nafadotride. D2-primed male rats showed enhanced nicotine sensitization as evidenced by statistically significant differences in …
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RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
Dysregulated D2R expression and function is implicated in the pathophysiology of many diseases including Parkinson’s disease, schizophrenia, and drug addiction. D2R trafficking is vital to proper D2R function. While the expression and activity of D2Rs are altered in the pathology of these diseases, …
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Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
… DNA element in the second intron of the dopamine-D2 receptor gene and shown that Freud-1 binds to this element in vitro as well as in chromatin, and mediates repression by this element. Importantly, specific depletion of Freud-1 protein levels resulted in upregulation of dopamine-D2 …
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Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
… that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of motor function. Common symptoms of PD include resting tremor, …
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Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors.
… past work, we have shown neonatal quinpirole (dopamine D<sub>2</sub>/D<sub>3</sub> agonist) treatment produces a significant increase in dopamine D<sub>2</sub> receptor sensitivity, a phenomenon known as D<sub>2</sub> receptor priming. Dopamine D<sub>2</sub> receptor priming is common in …
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The effects of a mixed dopamine D2/D3 agonist and antagonist on ethanol intake within a limited and a continuous access paradigm
The effects of the mixed dopamine D2/D3 agonist, quinpirole and antagonist, raclopride on ethanol consumption were examined within both a limited and a continuous access paradigm. The goals of these studies were to determine if decreases in ethanol intake after administration of the dopaminergic …
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FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… to safer and more effective drug therapies. The dopamine D2 receptor is the main target in therapies for Parkinson’s disease and schizophrenia. First and second generation antipsychotic drugs antagonize dopamine D2 receptor. Notably, both these classes of drugs may cause side effects associated …
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A Rat Model Examining Behavioral and Neurochemical Effects of Passive Exposure to Aggression on Observers
… and corticosterone, as well as the densities of dopamine D2 receptors and 5-HT1B receptors, among observer rats chronically exposed to aggression or non-aggression. No differences in the hormonal levels were detected between the groups of exposure to aggression and non-aggression, whereas …
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IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
… signaling. The ability of Gαi/o-coupled dopamine D2/D3 receptors and serotonin 5-HT1A/1B receptors to inhibit AC activity is reduced in AMPH self-administering rats. Moreover, the ability of Gαq-coupled mGluR1/5, but not serotonin 5-HT2A/2C receptors, to stimulate PLCβ activity is also …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… (IL-1β), serotonin (5-HT) receptor subtypes, and dopamine D2 receptors in the brainstem and cerebellum, as well as to elucidate the role of peripheral MCP-1 in cancer chemotherapy 5-flouracil (5FU)-induced changes in these CNS fatigue-related neural factors. Methods: Male C57/BL6 mice were used in …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… can affect the electrical activity of dopamine neurons in the ventral tegmental area (VTA) and of pyramidal neurons in the prefrontal cortex (PFC), using single-unit activity recording techniques. We have also investigated, whether these peptides can alter some dopamine-dependent …
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Nicotine Sensitization in a Rodent Model of Schizophrenia: A Comparison of Adolescents, Adults, and Neurotrophic Factors.
… is based on neonatal quinpriole treatment (a dopamine D2/D3 agonist) which causes increased D2 receptor sensitivity, a phenomenon known as D2 priming that is common in schizophrenia. D2-primed adolescent rats did not demonstrate nicotine-induced hypoactivity early in training, and males …
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The G protein-coupling specificity of D2-like dopamine receptors
The G-protein coupling specificity of D2-like dopamine receptors was investigated using both receptor-G protein fusions and membranes of cells in which pertussis toxin-resistant mutants of individual Gi-family G proteins could be expressed in an inducible fashion. A range of ligands displayed …
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The Deconstruction of Reinforcement Learning in Human Substance Use Disorder
… underwent pharmacological manipulations with dopamine D2/3 receptor agents, which found that both dopamine D2/3 receptor antagonist (400mg amisulpride) and agonist (0.5 mg pramipexole) differentially modulated behaviour in stimulant-addicted individuals: while both dopamine agents impaired …
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Altered Decision Behavior of Dopamine Receptor Knock-out Mice in a Free Binary Choice Task
Dopamine has been thought to play an important role in updating values according to reward prediction error by reinforcement learning theory, since the finding that phasic activity of midbrain dopamine neurons signals the difference between actual and predicted outcomes (reward prediction error). …
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Alcohol-induced Locomotor Activity in Zebrafish is Mediated by Activation of the Dopaminergic System
… locomotor activity and whole-brain dopamine levels. We found that zebrafish developed tolerance to alcohol's effect on locomotor and dopaminergic activity when continuously exposed to alcohol, highlighting the importance of the dopaminergic system. We correlated the alcohol-induced …
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IMPORTANCE OF THE D2 RECEPTOR FOR ONE- AND MULTI-TRIAL PSYCHOSTIMULANT-INDUCED BEHAVIORAL SENSITIZATION IN PREWEANLING RATS
… of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral sensitization during the middle and late preweanling period. In a series of four experiments, rats were injected with saline or the …
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Behavioral Mechanisms of Δ9-THC in Nonhuman Primates
… deficits were independent of changes in dopamine D2/3 receptor availability as measured with PET and [11C]-raclopride. THC-induced impairments to WM recovered during abstinence. Moreover, chronic THC treatment resulted in tolerance to the acute impairments in compound discrimination …
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