Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Dopa decarboxylase"”.
-
The epigenetics and role of Dopa Decarboxylase in heart development
… interference. Ddc_exonla codes for the Dopa Decarboxylase (Ddc) protein, which is predominately expressed in the developing myocardium, this points to a role in fetal heart development. The role of Ddc in cardiogenesis is explored using knockout mice lacking Ddc_exonla expression in …
-
Comparative analysis of Anopheles gambiae L-tyrosine decarboxylase and L-DOPA decarboxylase
A major pathway of tyramine and dopamine synthesis in insects is through the decarboxylation of tyrosine and DOPA, respectively. Although tyrosine decarboxylase (TDC) has been mentioned in some reports, it has never been critically analyzed. The high sequence identity shared by tyrosine …
-
ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΕΝΖΥΜΟΥ L-DOPA ΑΠΟΚΑΡΒΟΞΥΛΑΣΗ ΑΠΟ ΤΙΣ ΛΕΥΚΕΣ ΝΥΜΦΕΣ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA ΚΑΙ ΑΠΟ ΑΝΘΡΩΠΙΝΟ ΝΕΦΡΙΚΟ ΙΣΤΟ. ΣΥΓΚΡ...
L-DOPA DECARBOXYLASE IS A PYRIDOXAL PHOSPHATE-DEPENDENT ENZYME CATALYZING THE DECARBOXYLATION OF CERTAIN AROMATIC AMINO ACIDS TO THEIR RESPECTIVE AMINES. SINCE DOPAMINE IS INVOLVED IN MANY IMPORTANT METABOLIC PROCESSES PLAYING A CENTRAL ROLE IN THE PATHOGENESIS OF CERTAIN NEUROLOGICAL DISORDERS AND …
-
Mass Spectrometric Analysis of Tyrosine Metabolic Enzymes
… by many well-characterized enzymes including dopa decarboxylase and tyrosine hydroxylase. On the other hand, there are still many enzymes involved in these processes that we know very little about. Dopachrome tautomerase (DCT), dopachrome conversion enzyme (DCE) and α-methyldopa resistant …
-
Simulating biochemical physics with computers
… The second part is to investigate the role of dopa decarboxylase (DDC) in the catalysis of converting anti-Parkinson drug L-dopa into dopamine. By means of combined QM/MM potentials in MD simulations, we first analyze the factors contributing to the tautomeric equilibrium of an intramolecular …
-
Pheochromocytoma-induced cardiomyopathy : a model of synergistic effects of multifactorial tumor secretions
… encapsulated pheochromocytoma (PC12) cells, DOPA decarboxylase knock-out PC12 cells deficient in norepinephrine (PC12-KO), or norepinephrine-secreting pumps. Implanted PC12 cells induced a greater degree of cardiomyopathy than animals dosed only with norepinephrine. Elimination of …
-
Biochemical Studies of Aromatic Amino Acid Decarboxylases and Acetaldehyde Synthases
… of PLP-dependent enzymes, aromatic amino acid decarboxylases play critical physiological roles because many aromatic amines are essential neurotransmitters. This dissertation concerns the biochemical characterization of several PLP-dependent decarboxylases and aims to understand the …
-
Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
… of serotonin and all catecholamines, dopa decarboxylase (Ddc), was selectively ablated in Kiss1 neurons using CRE-Lox technique. There was no observable difference in fertility and fecundity parameters between wild-type and knockout mice. Thus, the role of serotonin and catecholamine …
-
DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… hypothesized that SARS-CoV-2 might affect the dopamine pathway [23–28] which in turn would interfere with neuronal activities. In this frame, it has been demonstrated both in-vivo and in-vitro that SARS-CoV-2 is able to infect different neuronal cell types with different degrees of success …