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Showing 1 to 20 of 77 for “"Dopa"”.
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Detection of Polypeptide Interactions Via Periodate Triggered Dopa Crosslinking
Protein-Protein interactions mediate most biological function, yet elucidation of the molecular architecture within a cell still remains a formidable challenge for molecular biologist. We have developed a novel, bioorthogonal cross-linking chemistry based upon periodate mediated oxidation of the …
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The epigenetics and role of Dopa Decarboxylase in heart development
… interference. Ddc_exonla codes for the Dopa Decarboxylase (Ddc) protein, which is predominately expressed in the developing myocardium, this points to a role in fetal heart development. The role of Ddc in cardiogenesis is explored using knockout mice lacking Ddc_exonla expression in …
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L-dopa metabolism and the regulation of brain polysome aggregation
Intraperitoneal administration of L-dopa {50-300 mg/kg) caused a marked disaggregation of brain polysomes in immature rats {15-20 g body weight). Polysome disaggregation was maximal between 40 and 60 minutes after injection and not significant at 20 and 120 minutes. Older rats {50 and 100 g body …
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Modification of Aplysia Feeding Network By L-Dopa and Dopamine-Dependent Learning
<p>Dopamine (DA) is a ubiquitous neuromodulator of neuronal networks in the animal kingdom and has a well-established role in modulating motor behavior and encoding reward information. Although the effects of DA and DA-dependent learning at the behavioral and molecular levels are well-understood, …
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Development and Optimisation of Nanoparticulate System for Brain Delivery of L-DOPA
… morbidity and a shortened life span. L-DOPA (LD) is the primary drug used for the treatment of PD. However, only 1% of the given dose is transported unchanged to the central nervous system (CNS) after oral administration due to its peripheral decarboxylation. As a result, LD has to be …
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Comparative analysis of Anopheles gambiae L-tyrosine decarboxylase and L-DOPA decarboxylase
A major pathway of tyramine and dopamine synthesis in insects is through the decarboxylation of tyrosine and DOPA, respectively. Although tyrosine decarboxylase (TDC) has been mentioned in some reports, it has never been critically analyzed. The high sequence identity shared by tyrosine …
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L-DOPA production in a liquid membrane enzyme reactor: process development and modeling
Opened per request of the author, 7/8/2026. See libanswers ticket https://libanswers.library.gatech.edu/admin/ticket?qid=18631263
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Μελέτη της έκφρασης και ρύθμισης της L-Dopa Αποκαρβοξυλάσης σε Bιοχημικούς μηχανισμούς Νευροεκφυλισμού
… τώρα έχει δείξει με τη μελέτη του μορίου της L-DOPA αποκαρβοξυλάσης ότι συμμετέχει τόσο στον αποπτωτικό θάνατο όσο και σε διεργασίες κυτταροτοξικότητας . Πρόσφατα δεδομένα της ερευνητικής μας ομάδας, έδειξαν τη σχέση της έκφρασης της L-DOPA αποκαρβοξυλάσης με την οξειδωτική καταπόνηση. Ακόμη και …
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The Effect of L-DOPA and Natural Products on Age-Related Motor Deficits and Dopaminergic Cell Survival
… for age-related motor deficits. However, L-DOPA is used for motor dysfunction in Parkinson's disease (PD). Therefore, we investigated the effect of L-DOPA on motor deficits in young (2 mo) and old (20 mo) mice. We found that L-DOPA reversed age-related motor decline.</p><p> Chronic L-DOPA …
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ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΕΝΖΥΜΟΥ L-DOPA ΑΠΟΚΑΡΒΟΞΥΛΑΣΗ ΑΠΟ ΤΙΣ ΛΕΥΚΕΣ ΝΥΜΦΕΣ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA ΚΑΙ ΑΠΟ ΑΝΘΡΩΠΙΝΟ ΝΕΦΡΙΚΟ ΙΣΤΟ. ΣΥΓΚΡ...
L-DOPA DECARBOXYLASE IS A PYRIDOXAL PHOSPHATE-DEPENDENT ENZYME CATALYZING THE DECARBOXYLATION OF CERTAIN AROMATIC AMINO ACIDS TO THEIR RESPECTIVE AMINES. SINCE DOPAMINE IS INVOLVED IN MANY IMPORTANT METABOLIC PROCESSES PLAYING A CENTRAL ROLE IN THE PATHOGENESIS OF CERTAIN NEUROLOGICAL DISORDERS AND …
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Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… motor symptoms, caused by degeneration of dopamine (DA)-producing neurons of the Substantia Nigra pars compacta (SNc). However, PD patients also suffer from many non-motor symptoms (NMS; eg. sleep disturbance, autonomic dysfunction, depression and anxiety), which cause significant …
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Effects of the Administration of 5-Hydroxydl-Tryptophan and 3,4-Dihydroxyphenylalanine on the Acquisition of a Conditioned Avoidance Response
… administration of 3,4-dihydroxyphenylalanine (L-Dopa) has been shown to result in the facilitation of performance while the administration of 5-hydroxytryptophan (5-HTP) results in an impairment of performance and reported enhancement of acquisition. The purpose of the present study is to compare …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
… PD is a characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra. Levodopa (L-dopa) and dopamine agonists have been most commonly used for symptomatic treatment. Since its initial introduction in 1967, L-dopa has been shown to be the most effective …
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Therapeutic strategies of Parkinson's disease: Alternative dopamine replacement and potential drug targets
… movement impairment and cognitive decline. Dopamine deficiency resulting from dopaminergic neuronal degeneration in substantia nigra (SN), known to be linked to mitochondrial dysfunction, ultimately manifests as the cardinal extrapyramidal motor symptoms of rigidity, bradykinesia, tremors, …
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A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease
Long-term dopaminergic therapy in Parkinson’s disease (PD) can lead to motor complications including dyskinesia which can be treated with amantadine, an N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
<p>Parkinson’s disease (PD) results from severe dopamine (DA) neuron loss within the substantia nigra pars compacta. In an effort to replace the diminished DA levels, L-dopa, the precursor of DA, is administered. Although the most commonly prescribed medication, the site(s) where L-dopa is …
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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking
<p>L-3,4 dihidroxyphenylalanine (l-DOPA) strongly stimulates motor activity in parkinsonian patients and animal models of Parkinson's disease. Severe striatal dopamine (DA) loss characterizes Parkinson's disease and its animal models. Given the canonical rate model of Parkinson's Disease …
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