Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Domain coupling."”.
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Multiscale Modelling of Molecules and Continuum Mechanics Using Bridging Scale Method
… is about developing a multiscale methodology for coupling two different time/length scales in order to improve properties of new space materials. Since the traditional continuum mechanics models cannot describe the influence of the nanostructured upon the mechanical properties of materials and …
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Atomistic insights into the structure, dynamics, and regulation of integral membrane proteins
… conformational dynamics, lipid modulation, and domain coupling mechanisms in membrane protein systems. In the first study, we present a complete structural model of the SARS-CoV-2 spike protein, which forms the basis for the high pathogenicity and transmissibility of the virus. The full-length …
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UNIQUE ALLOSTERIC MECHANISM REGULATING PROTEIN-PROTEIN INTERACTION THROUGH PHOSPHORYLATION: A CASE STUDY OF THE CONFORMATIONAL CHANGES IN THE SYK TANDEM SH2 PROTEIN
… Syk is a 72-kDa kinase comprising three folded domains: two SH2 domains and a catalytic domain. The tandem SH2 domains connected by linker A are key to the regulation of Syk activity. Immune signaling through Syk is initiated by the binding of the tandem SH2 to the dpITAMs found on immune cell …
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Biophysical studies of the allosteric regulatory mechanism of Syk tandem SH2 domains interacting with immunoreceptor tyrosine-based activation motifs
… with immunoreceptors through its tandem SH2 domains (tSH2), which contain two SH2 domains connected by interdomain A. The association of Syk with immunoreceptors is regulated by Y130 phosphorylation in interdomain A. The unphosphorylated tSH2 can bind with the doubly phosphorylated …