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Showing 1 to 6 of 6 for “"Dolichol"”.
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Examination of Abnormal Dolichol Metabolism in Infantile Batten Disease Caused by Palmitoyl Protein Thioesterase-1 (PPT1) Deficiency
… lysosome. It has been postulated that abnormal dolichol metabolism might be involved in NCL pathogenesis because high levels of dolichol phosphate (Dol-P) and lipid linked oligosaccharides (LLOs) accumulate in NCL patients including infantile NCL. Here, a possible relationship between fatty acid …
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Investigating the pathway of asparagine-linked glycoprotein biosynthesis
… enzymes, which together comprise the dolichol pathway. Despite over two decades of genetic and bioinformatics approaches that have identified the vast majority of dolichol pathway genes in yeast, the roles of two mannosyltransferases in the pathway, Alg2 and Algl 1, remained ambiguous. …
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Investigations in Enzyme Stereospecificity: I. The Stereochemistry of Cis-Double Bond Formation in Dolichol and Natural Rubber Biosynthesis. II. The Stereochemistry of Carbon-Sulfur 4ond Reduction by Methyl Coenzyme Reductase
Dolichol, a poly-cis polyprenol, is biosynthesized from isopentenyl pyrophosphate, IPP, and farnesyl pyrophosphate, FPP, as a branch from the pathway to squalene and cholesterol. Natural rubber, also a poly-cis polyprenol, is biosynthesized from Hevea latex in the same manner. The stereochemical …
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Congenital Disorder of Glycosylation (CDG) - Ih
… leads to the accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol.Genetic analysis of the alg2 mannosyltransferase cDNA revealed a deletion mutation which led to premature translation stop and loss of the C-terminal 45 amino acids. The patient was homozygous for this mutation …
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Applications of Solid State Nuclear Magnetic Resonance Spectroscopy as a Tool for Structure Based Drug Design
… in the synthesis of sterols, ubiquinones, dolichol, heme A, and a variety of carotenoids in plants. It is also the precursor for the condensation reaction to form dehydrosqualene by dehydrosqualene synthase, which finally forms the virulence factor staphyloxanthin in Staphylococcus aureus. …
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Characterisation of the PQ-loop repeat membrane protein family in arabidopsis thaliana
… from mammals involved in the utilisation of dolichol monosaccharides during glycosylation. The AtPQL family can be divided into three groups based on similarity with their non-plant homologues. Detailed sequence analysis was carried out to investigate conserved motifs, topology, domain …