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Showing 1 to 20 of 125 for “"Docosahexaenoic"”.
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
<p>Lipotoxicity (LTx) is involved in mostly every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. …
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Enteral docosahexaenoic acid supplementation to attenuate inflammation in the preterm infant
… associated with disease in the postnatal period. Docosahexaenoic acid (DHA) is an omega-3 long-chain polyunsaturated fatty acid (LCPUFA) with known immunomodulatory properties, however the effect of dietary DHA on the regulation of immune responses in preterm infants is largely unknown. This …
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Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain
… tissue analysis revealed neutral lipid (NL) docosahexaenoic acid (DHA) concentrations were greater (P < 0.05) in T3-fed pigs compared with T1-fed and SR pigs. Hippocampal phospholipid (PL) DHA concentrations of T2- or T3-fed pigs were intermediate to T1-fed and SR piglets. Diffusion tensor …
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Effects of Docosahexaenoic Acid on TGF-ß and SMAD Proteins in COLO205 and WiDr Cells
… are among the proteins known to be modified by docosahexaenoic acid (DHA) treatment in T-cells. Unpublished data has indicated that these proteins may be modified by DHA in colon cancer cells. In the current project, a thorough investigation of the effects of DHA on TGF-ß and SMAD protein …
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THE PROPHYLACTIC POTENTIAL OF DOCOSAHEXAENOIC ACID, AN OMEGA-3 FATTY ACID, IN TRAUMATIC BRAIN INJURY
… supplementation of ω3 FAs in vitro and in vivo. Docosahexaenoic acid (DHA) supplementation had the most effective incorporation into neural cells in vitro when compared to other ω3 FAs. Next, DHA was supplemented as both an unesterified fatty acid (FFA) and conjugated to lysophosphatidylcholine …
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
It is well documented that vitamin D and DHA have antiproliferative effects on a variety of human cancers, including breast cancer. Studies have shown that a combination approach to cancer treatment is more effective than any one treatment administered alone. In this study, human mammary epithelial …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
… acts as a carrier for the omega-3 fatty acid docosahexaenoic acid (DHA). The LDL-DHA nanoparticle has demonstrated cancer selective cytotoxicity with little ill effects on healthy cells. Our research began by selecting a panel of breast cancer cell lines representative of the various subtypes …
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The effects of docosahexaenoic acid combined with supporting nutrients and physical activity on mobility and cognitive function in older women.
There is a complex interplay between mobility and cognition in older adults. It has previously been shown that a high DHA multi-nutrient supplement improves habitual walking speed, verbal memory, and psychomotor response latency in older women. Exercise also improves mobility and cognition in older …
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The role of dietary arachidonic acid and docosahexaenoic acid in preventing the phenotype observed with highly unsaturated fatty acid deficiency
… (HUFA), mainly arachidonic acid (AA, 20:4ω6) and docosahexaenoic acid (DHA, 22:6ω3), are not completely understood. In order to study specific functions for AA and DHA, a delta-6 desaturase knockout (D6D-/-) mouse was created. D6D is a key enzyme in synthesizing HUFA from the precursor dietary …
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Physical Activity-Associated Differences in Placental Lipid Profiles and Docosahexaenoic Acid Uptake: Insights from Lipidomics and an In Vitro Exercise Model
… availability, and their downstream pathways. Docosahexaenoic acid (DHA) is a fatty acid of particular importance for fetal brain and retinal development, and its proper delivery to the fetus is critical. The influence of gestational PA on these factors has not been explored. Methods: The first …
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
… and male infertility. The long chain omega-3 docosahexaenoic acid (DHA) and omega-6 arachidonic acid (ARA) are highly unsaturated fatty acids (HUFAs) preferentially enriched in the sn2 position of membrane phospholipids and ARA is abundant in tissues throughout the body. DHA, however, is …
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Manothermosonication (MTS) and pH-shifting combined treatment for modifying the functional properties of plant proteins: protein-stabilized nanocarriers and protection of docosahexaenoic acid (DHA)
… nanocarriers to encapsulate and protect docosahexaenoic acid (DHA). In study one, a new physical and chemical combined treatment for protein modification, i.e. mano-thermo-sonication (MTS) with and without pH-shifting was developed. This method was tested using soy protein isolate (SPI) …
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Systemic and Intracellular Trafficking of Long-chain Fatty Acids in Lactating Dairy Cattle
… lipid encapsulated algae supplements increased docosahexaenoic acid content in milk fat while not adversely impacting milk fat yield; however, docosahexaenoic acid was preferentially esterified into plasma phospholipid, limiting its incorporation into milk fat. In the second study, triglyceride …
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Effects of algal docosahexaenoic acid in an extruded cat diet on nutrient digestibility, fecal characteristics and metabolites, and blood coagulation parameters and fatty acid profiles of plasma and red blood cell membranes
… polyunsaturated fatty acids (w3-PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are critical nutrients in feline diets. These nutrients are utilized as a key source of energy, in the transport of fat-soluble vitamins, in the formation of eicosanoids in inflammatory …
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Zinc and essential fatty acid status and supplementation in cystic fibrosis patients
… we studied. They have significantly lower docosahexaenoic acid (22:6n-3) and linoleic acid (18:2n-6) and higher dihomogammalinolenic acid (18:3n-6), oleic acid (18:1n-9) and Mead acid (20:3n-9), the latter being a sign of essential fatty acid deficiency. This resulted in increased ratios of …
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Development of Omega-3-Fatty Acid Enriched Finishing Feed and Value Added Tilapia Product
… acid, docosapentaenoic acid, and docosahexaenoic acid. The objective of this study was to create an omega-3 enriching feed that would increase omega-3 content in tilapia and subsequently decrease the omega-6:3 ratio. An 8 week feeding trial was conducted. Tilapia were cultured in a …
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The anabolic and anti-catabolic effects of long-chain omega-3 polyunsaturated fatty acid supplementation on functional muscular outcomes.
… LC n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have received considerable attention from the athletic and military communities for their potential application to physical performance and recovery. While multiple lines of evidence have provided valuable insight into …
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The Analysis, Characterization and the Chemical Syntheses of C(20) and C(22) Cyclic Fatty Acid Monomers Formed in Heated Fish Oil
… acids formed from both eicosapentaenoic and docosahexaenoic acids, C$\sb{20}$ and C$\sb{22}$ CFAMs respectively. Synthetic routes were developed to maximize the yield of both the intermediates and final products. Optimization of the chemical synthesis was carried out using the response …
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Iron and DHA in Relation to Early Cognitive Development
Iron and docosahexaenoic acid (DHA) are important nutrients for brain development. Negative effects of DHA supplementation when status of both nutrients is low have been shown on cognitive outcomes. We sought to determine if DHA status interacts with iron deficiency (ID) and influences offspring …
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