Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Docking sites"”.
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Determining the mechanism of protein transit through the peptidoglycan layer in Gram-positive bacteria and identifying phage-docking sites on Clostridium perfringens
… to develop an effective phage therapy, phage docking sites need to be identified. Docking sites would allow for implementation of phage engineering and aid in the determination of untested phages that would be predicted to bind. Phage therapy may be a promising alternative treatment method to …
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… of CAM-mediated endocytosis to the formation of docking sites and vesicular structures supporting TEM was explored in this study. Results show that the ICAM-1/NHE1-dependent CAM-mediated pathway associates with acid sphingomyelinase and ceramide. This supports plasmalemma deformability and …
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Geometric modeling and optimization in 3D solar cells : implementation and algorithms
… of SA lead me to restrict the solar cell docking sites to orthogonal grids imposed on the building surfaces. The resulting program is an elegant trade-off between accuracy and efficiency.
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ClpX interactions with ClpP, SspB, protein substrate and nucleotide
… itself and bound substrate to ClpX, via docking sites located in the dimeric N-terminal domain of ClpX. Because this N-domain dimer binds only a single SspB subunit, the ClpX hexamer can accommodate just one SspB dimer per hexamer. Other adaptor proteins that use these same tethering …
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Systematic Identification of Interaction Partners of RET Receptor Isoforms
… that were mediated through RET isoform-specific docking sites. Our results suggest that combinations of distinct interaction partners may contribute to RET isoform-specific functions. In this research we developed a systematic approach to map and characterize RET isoform interactions. Our data …
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B-Cell Epitope Prediction for Improved Antibody Docking
… an antibody-target complex, otherwise known as docking, is an important tool in drug design, providing valuable insights such as ways to increase antibody potency or methods to limit the likelihood of a mutational escape. State of the art models of antibody docking treat the task as a regression …
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Flagellum assembly in protozoan parasites
… the next cell cycle. Transition fibres serve as docking sites for axonemal proteins, ensuring proper flagellum assembly and length maintenance. In Leishmania, flagella elongate over multiple cell cycles, and we identified CEP164C as a regulator of flagellum growth, instead of as part of a locking …
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Advances in the stochastic and deterministic analysis of multistable biochemical networks
… these models have not considered enzyme docking, the binding of the enzymes to one or more substrate docking sites, which are separate from the motif that is chemically modified. Enzyme docking is, however, increasingly being recognised as a method to achieve specificity in protein …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
… Then, I determined that the Y1349 and Y1356 docking sites and tyrosine kinase activity of HGFR were required for receptor internalization. Recruitment of the adaptor protein Grb2, but not Gab1, was essential for ligand induced HGFR internalization. I then showed Cbl, an E3 ubiquitin ligase …
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Chemical Reactivity and Regioselectivity of Trimetallic Nitride Endohedral Metallofullerenes
… computational approach to predict multiadduct docking sites on the ellipsoidal fullerene cage surface. We also successfully synthesized the first derivative of a non-IPR fullerene, the diethyl malonate derivative of Sc3N@C68 by a Bingel-Hirsch reaction. The reactivity and regioselectivity of …
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Mechanisms of Eph/ephrin mediated cell-cell communication
… of the cytoplasmic domain, initiating docking sites for downstream signaling adaptors. Moreover, ephrinB ligands can signal by interactions with various PDZ-domain containing proteins. Using a broad range of in vitro assays the presented work demonstrates that upon binding to their …
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Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding
… mutation of multiple ubiquitin acceptor sites (lysine residues) in HIV-1 and RSV Gag proteins markedly inhibits budding. However, the precise role of ubiquitin in retroviral particle release is poorly understood. To test the importance of direct Gag ubiquitination for viral particle …
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Primate-specific KRAB zinc finger proteins and their targets rewire regulatory networks related to inflammation and pancreas development
… genomic integrity. TEs are known to contain docking sites for host’s transcription factors and contain transcription regulatory elements including promoters, enhancers and silencers. The differential expression patterns observed for members of the KZFP subfamily amongst different biological …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… interactions, and in particular protein-peptide docking interactions, within two independent cellular signaling pathways, the WNK, and ERK1/2 MAPK pathways. The WNK pathway is an essential regulator of cellular ionic composition and volume. Initially discovered due to the genetic link between …
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The chromatin landscape of colorectal cancer cells
… oriented and CTCF enriched CTCF-binding sites (CBSs) come into contact within the ring, cohesin is thought to "hand-cuff" the chromatin resulting in the formation a chromatin loop. These loop structures then serve to compartmentalize and restrict the chromatin contacts and their frequency …