Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"DoHAD"”.
-
IMPACT OF NUTRIENT IMBALANCE ON THE EPIGENETIC SIGNATURE AND GENE EXPRESSION OF BOVINE EARLY EMBRYOS
The Developmental Origins of Health and Disease (DOHaD) theory emphasizes the long-term health implications of maternal nutritional imbalances during pregnancy. This study focuses on how variations in energetic substrates during preimplantation development affect gene expression, differential …
-
One Meal at a time: Nourishment in the Cape Winelands
… 'Developmental Origins of Health and Disease’ (DOHaD) propose the 'first thousand days’ of life as a critical period for the formation of new life. During this time food is one crucial set of signals that edits life, and is particularly pertinent in the South African context where entrenched …
-
Effect of nicotine and alcohol exposure in utero on vascular intima medial thickness, endothelial function, and the development of cardiometabolic risk factors in children in a low-income setting.
… The Developmental origins of Health and Disease (DoHaD) hypothesised that prenatal exposures will result in long-lasting, if not permanent adaptations in the structure, physiology and metabolism in the foetus, therefore predisposing children to CVD later in life. Several studies have reported …
-
Investigating the nutritional and social determinants of favorable fetal growth conditions (FFGC) in pregnant women living in the Free State Province, South Africa
… the Developmental Origins of Health and Disease (DOHaD) theory. Current DOHaD research relies on low birth weight as the main indicator for assessing the fetal environment, but statisticians have developed a latent construct known as Favorable Fetal Growth Conditions (FFCG), that considers birth …
-
Neurochemical, epigenetic, and structural brain changes associated with prenatal stress exposure, and the mitigating effects of DHA
The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that in utero stress exposure can modify developmental trajectories, influencing adult health. Research indicates that maternal stress can negatively impact neurodevelopment, especially in individuals genetically predisposed …
-
Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
… the developmental origins of health and disease (DOHaD), or sometimes fetal programming. MUN during pregnancy may affectdeveloping organs to alter the phenotypic outcome of the offspring to promoteadult disease. The timing of the insult is also critical. During the periconceptionalperiod and early …
-
The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… The Developmental Origins of Health and Disease (DOHaD) theory suggests that adversity in prenatal and early life, influence offspring health. Multiple studies have now shown that the maternal environment (GDM, diet and stress) can affect placental growth, birthweight, and programme the …
-
The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… the Developmental Origins of Health and Disease (DOHaD) hypothesis, abnormalities in fetal nutrient supply and growth can programme the offspring to develop altered metabolic health in later life. Despite this, little is known about the role of the endocrine placenta in fetal nutrient supply, …
-
Exploring the sex-specific programming of cardiovascular disease by maternal obesity and assessing potential interventions to the mother
There are currently over 1.9 billion adults globally who are overweight or obese. As the prevalence of obesity increases worldwide this includes women of childbearing age. Over half of all women of reproductive age in the UK are currently classed as overweight or obese. Obesity during pregnancy is …
-
Nutritional Stress & Early Development in the Neolithic Near East: A Comparison of Adult and Subadult Tooth Size
The transition from hunting and gathering to farming during the Neolithic Revolution in the Near East came with a diet that relied heavily on domesticated crops. This change in diet could lead to a reliance on lower nutritional quality foods compared to the hunter-gatherer diet. Such a decline in …
-
Maternal Obesity During Pregnancy: Cardiovascular Outcomes for Mother and Baby
… the Developmental Origins of Health and Disease (DOHaD) hypothesis, which states that exposure to suboptimal environments during development programmes changes in long-term health. Together, this shows that maternal obesity during pregnancy is associated with poor cardiometabolic health in both …
-
Bridging the Gap - Exploring the Role of Cortisol on The Effects of Prenatal Depression on Child Neurocognition
Prenatal depression is a potentially debilitating experience that can affect both birthing parent and child. The current study investigates the role of cortisol, a hormone well-known for its involvement in the stress response, in the association between prenatal depression and child neurocognitive …
-
The immediate and long-term consequences of temporary exposure during adulthood to di(2-ethylhexyl) phthalate and diisononyl phthalate on female reproduction
The ovary is a heterogenous structure that produces a variety of sex steroid hormones and participates in several feedback loops within the hypothalamic-pituitary-ovary axis. Further, it is the site of storage and maturation of the female gamete: the oocyte. Females are born with a finite number of …
-
Adult behaviour and cerebral cell densities after maternal or post-weaning consumption of an obesogenic diet in mice
Adult behaviour and cerebral cell densities after maternal or post-weaning consumption of an obesogenic diet in mice Emily Jane Mort Maternal obesity during pregnancy impairs cardiometabolic health of the adult offspring in experimental animals, and is associated with behavioural and cognitive …
-
Developmental exposure to an environmentally relevant phthalate mixture impacts ovarian health in mice
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01