Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Dnmt3b"”.
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Regulation of De Novo and Maintenance Dna Methylation By Dnmt3A and Dnmt3B
… of DNA methyltransferases (DNMTs): DNMT3A and DNMT3B function primarily as <em>de novo</em> methyltransferases that establish DNA methylation patterns, whereas DNMT1 is the major enzyme responsible for maintaining DNA methylation patterns by converting hemi-methylated CpGs to fully methylated …
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Molecular Characterization of Mammalian De Novo DNA Methyltransferase Chromatin Recruitment
… novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) is facilitated in part by chromatin "reader" domains to establish DNA methylation patterns genome-wide. Recent work has highlighted a role for the PWWP reader domain in directing recruitment of DNMT3B to actively transcribed gene bodies. …
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Identification of Factors Involved In Dna Methylation of Cpg-Island-Promoters
… In the second part, we re-introduced disrupted DNMT3B or DNMT1 into HCT116 DKO cells and mapped the remethylation pattern through a profiling method (DREAM). Moderate remethylation occurred when DNMT3B was re-expressed with a preference toward non-CGI and non-promoter regions. Hence, there …
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Étude du lien antagoniste existant entre la méthylation de l'ADN et le variant d'histoire H2A.Z : rôle du complexe TIP60/P400
… en induisant la dégradation de Dnmt1 ainsi que Dnmt3B. D’une autre, en maintenant certaines régions régulatrices libres de méthylation de novo. Le complexe Tip60-p400 serait associé préférentiellement à des régions contenant H2A.Z et protègerait ainsi ces régions de la méthylation de l’ADN en …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
… DNMT3A, and the down-regulation of DNMT1 and DNMT3B, a pattern of expression which is re-capitulated in HL cell lines. I have also shown that the major EBV oncogene, LMP1, is responsible for the down-regulation in GC B cells of DNMT1, and that DNMT3A binds to the EBV promoter, Wp which is …
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Application of High-Performance Liquid-Chromatography Mass-Spectrometry Platform to Study Metabolism and Epigenetic Control of Metabolism
… There are two de novo DNMTs, DNMT3A, and DNMT3B. These DNMTs establish the pattern of methylation. We examined de novo DNMT-mediated control of cellular metabolism, identifying global changes in metabolism, as well as differential sensitivity towards glycolytic and mitochondrial …
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The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
… In particular, the PWWP domains of DNMT3A and DNMT3B are posited to interact with histone 3 lysine 36 trimethylation (H3K36me3). In this study, I characterise a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain, predicted to ablate the DNMT3A-PWWP and H3K36me3 interaction. …
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Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems
… by de novo DNA methyltransferases Dnmt3a and Dnmt3b along with their catalytically inactive co-factor Dnmt3l, while these DNA methylation patterns are maintained through cell divisions by maintenance methyltransferase Dnmt1. The exact mechanisms by which these DNA methyltransferase enzymes are …
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Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies
… to alterations in the expression of the DNMT3A, DNMT3B or DNMT3L genes. Finally, despite the persistence of the repressive histone mark H3K9me3 following 5-Aza-dC treatment we find that, in this model, inhibitors of H3K9 methyltransferases do not delay gene re-silencing. These findings show that …
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Identification and Characterization of Hells-CDCA7, a Nucleosome Remodeling Complex Required for Mitotic Chromosome Structure
… heterochromatic nucleosomes facilitates DNMT3B-mediated methylation and discuss this model alongside alternative models for ICF syndrome. Finally, I consider the role of CDCA7 paralogs in differentially regulating HELLS, and present an outlook on the future of ICF syndrome research. </p>
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… high levels seen on TFH cells. Our discovery of DNMT3b as a target for BCL6 suggests BCL6-deficient T cells have increased DNA methyltransferase activity at the PD-1 promoter. This data establishes a novel pathway for explaining how BCL6, a transcriptional repressor, can activate genes. …
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DNA Methylation and DNA Methyltransferases in the Clonal Raider Ant, Ooceraea biroi
… and mutations lead to embryonic (DNMT1 and DNMT3b) or post – natal (DNMT3a) lethality. Studies of DNA methylation and DNMTs in invertebrates have been limited to non – traditional model organisms because Caenorhabditis elegans and Drosophila melanogaster lack the DNMT enzymes, and their DNA …
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Effect of rumen-protected methionine on placenta metabolism, animal performance, and immune-metabolism of dairy cows during the periparturient and early lactation periods
… The de no DNA methyltransferase (DNMT3A and DNMT3B) were upregulated in Female MET than Female CTR. Global DNA methylation was lower in Female MET than in Female CTR placenta. No difference in calf birth weight was observed between Female CTR and Female MET; but, calves from Female MET were …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… selective inhibitor of DNA methyltransferase 3B (DNMT3B), which reportedly inhibits DNA methylation and thus reactivates the expression of silenced genes. Nanaomycin A was one of the most potent drugs in 13/14 ALK-driven lines tested and may thus serve as a novel front-line therapy. I also …