Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Dna2"”.
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The Functions of Human Dna2 in Mitochondrial and Nuclear DNA Maintenance
… on delineating the biological functions of human Dna2: hDna2). Dna2 is a highly conserved helicase/nuclease that in yeast participates in DNA replication and Okazaki fragment maturation, DNA repair, and telomere maintenance. Immunofluorescence and biochemical fractionation studies demonstrated …
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Functions of Human DNA2 and its Protein Partners in DNA End Resection
… of diseases such as cancers could occur. The DNA2 enzyme was shown to have essential roles in DNA metabolism. In human cells DNA2 was implicated in the completion of DNA replication and the repair of DNA double- strand breaks via the homologous recombination pathway. In addition, DNA2 was …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… in NPSD4-deficient cells is dependent on the DNA2 nuclease and proteins that promote fork reversal. Thus, my findings indicate that NPSD4 protects stalled replication forks through limiting BLM levels, inhibiting aberrant resection of reversed stalled forks by BLM/DNA2. These results identify …
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Essentiality of Mitochondrial Genome Integrity in Cell Survival
… in the mitochondria have been proposed: EXOG, DNA2, and FEN1. EXOG is the only endo/exonuclease that exists exclusively in the mitochondria, and my results suggest that EXOG is the predominant 5’ end cleaning enzyme in mitochondrial LP-BER. Immunoprecipitation of EXOG-FLAG immunocomplex showed …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… an event which is mediated by the MRE11-DNA2-BLM pathway. Moreover, following exogenous induction of DNA replication stress, HORMAD1 deleted cells accumulate single stranded DNA (ssDNA). We find that these phenotypes are the result of a lack of RAD51 and BRCA2 loading onto stalled …
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… of the stalled replication forks by inhibiting DNA2 nuclease. Deficiency of Abro1 leads to stalled replication fork degradation and genomic instability. Moreover, Abro1-null mice show signs of inflammatory response such as enlarged spleens, increased numbers of T cells and B cells, elevated …
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ATR SIGNALING IN GENOME REPLICATION AND MAINTENANCE
… mode of Mec1 action requires the Dna2 or the Ddc1 lagging-strand replication factors and is distinguishable from Mec1’s action in activating the downstream kinase Rad53. I also found evidence supporting that in humans, ATR can also function in a replication-correlated manner. …