Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Dna Helicases"”.
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Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
… aus Saccharomyces cerevisiae kodiert für eine DNA-Helikase, die an der nicht-fehlerbehafteten Überbrückung von DNA-Lesionen durch homologe Rekombination beteiligt ist. Simultane Deletion der Gene MPH1 und SRS2 - das ebenfalls für eine DNA-Helikase kodiert - resultiert im Hefe-Hintergrund …
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XPD Helicase: Shifting the Inchworm Into Reverse
Directional translocation by helicases results in duplex separation and displacement of bound proteins which allows for the DNA processing events associated with DNA repair, replication, recombination, and transcription. Unresolved questions regarding DNA helicases include: (1) how is directional …
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Homologous Strand Exchange and DNA Helicase Activities in Plant Mitochondria
… organisms by exchange and rearrangement of DNA. Most of our knowledge about homologous recombination is limited to processes in bacteria or in eukaryotic nuclei. In E. coli, homologous recombination is dependent on the RecA protein. Higher plant chloroplasts have RecA-like strand exchange …
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An ORC Flip Enables Bidirectional Helicase Loading
… identity and ensure viability. The first step in DNA replication is the licensing of all potential origins by loading two inactive Mcm2-7 replicative DNA helicases around the origin DNA in a head-to-head double hexamer. This conformation prepares the helicases to initiate bidirectional replication …
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Single molecule fluorescence studies of replicative helicases
DNA helicases are motor enzymes that convert the chemical energy of nucleotide triphosphate hydrolysis into mechanical energy for translocation on single stranded (ss) DNA and unwinding of double stranded (ds) DNA. All of the 12 known replicative helicases are hexameric helicases that are …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… suggested that RUVBL1/2 may have roles in DNA replication in NSCLC, and inhibition or depletion of RUVBL1/2 in sensitive NSCLC lines delays S-phase progression and ultimately results in cancer cell death via replication catastrophe. While Compound B treatment in vivo produces modest …
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SMARCA4/BRG1-Inactivating Mutations as Potential Predictive Markers for Aurora Kinase A-Targeted Therapy in NSCLCs
SMARCA4 encodes a catalytic subunit of the SWI/SNF chromatin remodeling complex, BRG1. Frequent occurrence of SMARCA4/BRG1-inactivating mutations and their mutually exclusive nature from EGFR and ALK lesions create one of the largest subsets of Non-Small Cell Lung Cancers (NSCLCs). Since these …
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Expeditious detection of DNA damage: Probing the sequence-sensing and damage-sensing mechanism(s) of the XPD helicase
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01