Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Dna Damage Sensing"”.
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Investigating mechanisms of ovotoxicity of Perfluorooctanoic acid and Zearalenone exposure and the influence of altered metabolic status on ovarian function
… no impacts of obesity on several markers of DNA damage were noted, LC-MS/MS analysis provided mechanistic insight into the impact of obesity in a rat model on ovarian endpoints related to genotoxicant response. Per- and polyfluoroalkylated substances (PFAS) including PFOA are characterized by …
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The interaction of CtIP with DNA damage response proteins
… in vivo with, and directly binds to, the DNA damage mediator proteins containing BRCT domains: 53BP1, MDC1, TopBP1 and NBS1. The binding sites on all of these proteins have been mapped establishing which regions of CtlP interact directly with 53BP1, MDC1, TopBP1 and NBS1 and vice versa. …
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Inhibition of PLK1 by p53 and by PLK1-targeted drugs
… arrest in prometaphase and activation of the DNA damage response. Part of this thesis aimed at investigating the DNA damage response (DDR) induced in mitosis by PLK1 inhibitor and the consequences of such inhibition. Also, the results were compared with the results obtained/reported in …
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Expeditious detection of DNA damage: Probing the sequence-sensing and damage-sensing mechanism(s) of the XPD helicase
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01