Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Dll4"”.
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DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy
… the effects of the Notch ligands, Delta-like 4 (DLL4) and Jagged-1 (JAG1) on tumour resistance to TMZ and GCSCs. Methods: U87 and U251 glioblastoma cells were transduced with empty vector-, DLL4, and JAG1-encoded retroviruses. Cells were cultured under 2D, 3D, and CSC culture conditions and …
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Effect of ATF2 transcription factor on DLL4 gene expression in angiogenesis
… of the enhancers and the promoter of the DLL4, which is an angiogenic-related gene, were obtained from the ensembl website and using the ConTraV3 R software, the putative binding sites of ATF2 on the regulatory regions of DLL4 were identified. Among the four enhancers and the promoter …
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
… which was associated with enhanced Notch1-Dll4 signalling. In the presence of induced Dll4 expression the epithelial-like phenotype was further enhanced culminating in excessive cell-cell aggregation and the lack of any observable effect with γ-secretase inhibition indicated that augmented …
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EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
… partner 1 (EHBP1) regulate Delta like ligand 4 (Dll4) endocytosis by tethering its caveolar endocytic pit to the actin cytoskeleton.</p>
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… that the Notch ligand Delta like ligand 4 (DLL4) plays a critical role in this process. DLL4 is essential for the formation of mature blood vessels during development and in several tumor models. Inhibition of DLL4 causes increased vascular sprouting, decreased pericyte coverage, and …
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Development of novel polymeric nanoparticles for pancreatic cancer therapy
… C-terminal Cys bearing anti Delta-like ligand 4 (DLL4) VNARs conjugated to the resultant NPs. Their binding capabilities were then examined which, while functional, were not as potent as a more routine maleimide PLGA-PEG NP approach.<br/><br/>Secondly, the potential of anti-DLL4 VNAR conjugated …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… lymphatic endothelium, and Delta-like ligand 4 (Dll4) is the predominantly expressed Notch ligand in the developing lymphatic vessels of the embryonic dermis and pathological lymphatic vessels of the wounded cornea. Dll4 was able to induce Notch activation in human dermal lymphatic endothelial …
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A study of Notch signalling in developmental angiogenesis
… have shown that the Notch ligand, Delta-like 4 (Dll4), is prominently expressed in tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic deletion of one Dll4 allele …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… are hallmarks of thymic development, FoxN1 and Dll4, regulate Wnt-5b genetic expression in vitro. However, further work is needed to determine if Wnt-5b is affecting TEC development through canonical or non-canonical Wnt signaling and whether the modulation is due to an altering of cell-fate, …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… regulator of angiogenesis) ligand DLL1 and DLL4. Additionally, we investigated genomic changes that may be involved in the development and progression of breast to brain metastasis (BBM). Whole exome sequencing (WES) of 26 breast to brain metastases was carried out. Bioinformatic analysis of …
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Identifying Novel Molecular Mechanisms Underlying Lateral Line Organ Development in Sterlet
… developing neuromasts but not AOs, and four (Dll4, Axin2, Omg and Gpr52) within developing AOs but not neuromasts. (Other genes with specific expression patterns were expressed in non-lateral line structures such as gill filaments and taste buds.) I explored the Bmp signalling pathway in the …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …