Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Dll1"”.
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Regulation of Notch Ligands Dll1 and Jag1 by Pax6 during cortical development
… relationship between Pax6 and Notch ligands Dll1 and Jag1 during cortical development. Analysis by flow cytometry and double labelling analysis of both gene and protein expression has provided insight into the relationship between Pax6 and Dll1 in progenitor cell subpopulations during …
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Novel Notch signalling dynamics within the molecular oscillator underlying vertebrate segmentation
… ligand and receptor in the PSM, Delta-like 1 (Dll1) and Notch1, are shown to vary dynamically across the PSM of both chick and mouse. This proposes that the signalling components mediating intercellular coupling of pulsatile gene expression themselves exhibit oscillatory behaviour. …
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The Role of Cdx in Intestinal Development
… operates upstream of Notch ligand Delta-like 1 (Dll1) in endoderm and mesoderm derivatives, demonstrating that Cdx function is similar in different lineages. Finally, Cdx2 cannot fulfill the requirement for Cdx1 in regulation of its own promoter in the intestine. This is the first in vivo …
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OVEREXPRESSION OR REDUCED BIOAVAILABILITY OF VEGF DURING MOUSE POST-NATAL INTESTINAL DEVELOPMENT ALTERS THE PROLIFERATION OF INTESTINAL STEM CELL PROGENITOR CELLS
… measured length and reduced expression of <em>Dll1</em> and <em>Bmp4</em>. Overall the availability of VEGF has the ability to alter the proliferation of progenitor cells in the crypt by either a direct or indirect signals. These studies reveal that by some means VEGF is altering the developing …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… pathway (major regulator of angiogenesis) ligand DLL1 and DLL4. Additionally, we investigated genomic changes that may be involved in the development and progression of breast to brain metastasis (BBM). Whole exome sequencing (WES) of 26 breast to brain metastases was carried out. Bioinformatic …
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Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
… endothelial cells, however in this case with via DLL1. Here we have investigated, with a focus on high-risk patients, key signalling patways that are involved in the maintenance and progression of the disease. In addition, we describe a novel prognostic signature that has clinical implications for …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… with ECM proteins. The Notch ligands Jag1 and Dll1 were further found to found play distinct cell-intrinsic and cell-extrinsic roles in differentiation towards a biliary epithelial cell fate. Parallel TFM measurements in arrayed microenvironments indicated that progenitor cell differentiation …
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Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… led to increased expression of Notch ligand DLL1 and Notch target gene Hey1 in VEGF-stimulated HUVEC. Expression of the transcription factor c-Fos was also elevated after PMCA4 knockdown in HUVEC stimulated with VEGF for 1h. Analysis of a gene array containing genes encoding extracellular …
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Identifizierung und Charakterisierung von Genen für die Entwicklung der Nieren und des Urogenitalsystems
… Diese Vermutung konnte durch die Analyse von Dll1-Knockout-Mäusen für die Somitogenese ansatzweise bestätigt werden. Die Kombination von Transfilter-Organkultur mit ddPCR erwies sich als geeignet, um transkriptionell regulierte Gene des metanephrogenen Mesenchyms zu identifizieren. …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …