Global ETD Search
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Showing 1 to 3 of 3 for “"Dlk2"”.
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Role of the atypical Notch ligand Dlk2, and it’s relationship with Dlk1 in mammalian neurogenesis
… homologue 1 (Dlk1) and Delta-like homologue 2 (Dlk2) are vertebrate-specific non canonical Notch ligands. Dlk1 is an imprinted gene, generally expressed from the paternally inherited chromosome. Previous work has shown early expansion of the V-SVZ neurogenic niche in Dlk1 mutant mice in the …
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Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development
DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. Dlk1 is imprinted throughout murine development [76] but selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism [78]. Possessing both secreted and membrane-tethered isoforms[212, 211], DLK1 plays …
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Function and evolution of the atypical Notch ligands Dlk1 and Dlk2 during vertebrate development
Delta-like homologue 1 (Dlk1) and Dlk2 encode vertebrate-specific transmembrane proteins belonging to the Jagged/Delta/Serrate family of Notch ligands. Murine Dlk1 is widely expressed during embryonic development and targeted deletion results in defects in numerous developmental processes, such as …