Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Dlk1"”.
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Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development
DLK1 and DLK2 are vertebrate specific non-canonical Notch ligands. Dlk1 is imprinted throughout murine development [76] but selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism [78]. Possessing both secreted and membrane-tethered isoforms[212, 211], DLK1 plays …
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Function and evolution of the atypical Notch ligands Dlk1 and Dlk2 during vertebrate development
Delta-like homologue 1 (Dlk1) and Dlk2 encode vertebrate-specific transmembrane proteins belonging to the Jagged/Delta/Serrate family of Notch ligands. Murine Dlk1 is widely expressed during embryonic development and targeted deletion results in defects in numerous developmental processes, such as …
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Role of the atypical Notch ligand Dlk2, and it’s relationship with Dlk1 in mammalian neurogenesis
… and cell fate decisions. Delta-like homologue 1 (Dlk1) and Delta-like homologue 2 (Dlk2) are vertebrate-specific non canonical Notch ligands. Dlk1 is an imprinted gene, generally expressed from the paternally inherited chromosome. Previous work has shown early expansion of the V-SVZ neurogenic …
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Genes with Physiological Roles in Callipyge Muscle Hypertrophy
… in muscle growth since the up-regulation of DLK1 and/or RTL1 results in extreme postnatal muscle hypertrophy in loin and hindquarters. DLK1 and/or RTL1 are the primary inducers of muscle hypertrophy due to the inheritance model for the callipyge phenotype. The overall aim of this dissertation …
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Molecular Control of Tooth Mesenchymal Stem Cell Activation
… including tissue specific RBP-Jκ knock out, Dlk1 null, and tissue specific Dlk1 overexpressing strains. In vitro models were developed to validate findings. Results MTAC and MSC containing regions exhibited distinct expression signatures of quiescent MSC marker genes. Notch pathway ligands, …
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Función de la Proteína PTTG1 en la Regulación de la Expresión del Gen dlk1 en procesos de Proliferación y Diferenciación Análisis funcional de las Isoformas PTTG1, PTTG2 y PTTG3
Los objetivos planteados en esta Tesis han sido los siguientes: 1. Teniendo en cuenta la capacidad transactivadora de PTTG1, un objetivo de este trabajo ha sido analizar los cambios de expresión génica producidos por la sobreexpresión de PTTG1 en células no tumorales, con el fin de determinar genes …
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Investigation of MicroRNAs in Lupus-Prone Mice
… cluster (miR-183C) and miRNAs located at DLK1-DIO3 region. The work presented in this dissertation focuses on comparing the dysregulation pattern of miRNAs from different cell sources of lupus-prone mice and investigating the potential role of miR-183C in the pathogenesis of SLE and …
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Defining the Transcriptional and Epigenetic Signature of Mouse Embryonic Stem Cells with Compromised Developmental Potency
… Rian and Mirg are all located in the imprinted Dlk1-Dio3 region on chromosome 12 and are normally expressed from the maternal genome. This pattern was also validated in tissues from e17.5 chimaeric embryos. The expression of this locus is to a large extent regulated by a differentially …
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Regulação da adipogênese e da secreção de quemerina por ácidos graxos de cadeia média e pelo ácido graxo eicosapentaenóico em células 3T3-L1
… a expressão gênica de: fator preadipogênico (DLK1); Wingless related MMTV integration site 10b (WNT10b); proteínas ligantes ao amplificador CCAAT (C/EBP) β, δ e α; PPARγ e quemerina. A incorporação de lipídios foi avaliada por Oil Red-O. Ainda, para o estudo sobre quemerina, adipócitos maduros …
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Early life phenotypes of type 1 diabetes genetic risk
… birth was detected by variants in the imprinted DLK1 gene, the vitamin D metabolism CYP2R1 gene and the gene encoding TYK2 known for its susceptibility to infections. Examination of longitudinal phenotypes identified that infancy growth is influenced by genes with a key role in innate immunity, …
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Identification of Subclass-Specific Biomarkers by Developing an Integrated Database of Breast Cancer
… and tumor suppressor genes like MUCL1, CLCA2 and DLK1 were down expressed in ERBB2 negative class. In case of a high stage case, overexpression of cancer metastasis related genes including MMP12 and BCL2A1, CXCL5 are observed. On the other hand, FOS, which known as oncogenes, and TFF2, which is …
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Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… insulin resistance, b) miR-143 that inhibits DLK1 that inhibits adipocyte differentiation through ERK1/2 activation, c) miR-21 that impaired TGFBR2-induced inhibition of adipocyte differentiation and seems to be related to serum adiponectin concentration. Furthermore, from the selected …
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Molecular mecanisms involved in the pathogenesis of head and neck paragangliomas
… el cluster miR-379/miR-656, además de los genes DLK1 y MEG3 adyacentes al cluster de miRNA. Estos miRNA ejercen papel importante en la regulación de la diferenciación neuronal, embriogénesis y mantenimiento de las células madres.
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Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle
… classical preadipocyte markers, such as PDGFRA, DLK1, PPARG, CD34, and ZNF423, validating their preadipocyte identity. Notably, IMF-derived clones maintained high expression of muscle-specific genes (e.g., MYOG, CKM, MYH2, MYH3), even after adipogenic differentiation. Functional enrichment …