Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Dkk1"”.
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Regulation of Dkk1, an Inhibitor of the Wnt Signaling Pathway, by DAX-1 in Mouse Embryonic Stem Cells
… methodology (Torres 2013). The Dickkopf 1 gene (Dkk1) was identified as a potential target of DAX-1 by these studies and has since been confirmed to be a DAX-1 target in mESC. However, to date very little is understood of the mechanism of DAX-1 repression of Dkk1 in mESC. In order to better …
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A decrease in dkk1, a Wnt inhibitor, contributes to placental and fetal lipid accumulation in an obesity-prone rat model
Made available in DSpace on 2011-05-25T15:06:43Z (GMT). No. of bitstreams: 6 Appendix B-qRT-PCR Curves.pdf: 4421573 bytes, checksum: e9ba82137f083fa9f50680e7baf8c92c (MD5) Appendix A-Rodent Obesity Models.pdf: 102817 bytes, checksum: d22fc8b17473156234c55d696e75cadd (MD5) Strakovsky_Rita.pdf: …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… in the negative regulators of the Wnt pathway, Dkk1 and Nkd1, with decreased immune infiltration in ovarian cancers. To interrogate the functional importance of these negative regulators further, I knocked out and expressed Dkk1 and Nkd1 in murine ovarian cancer models ID8 p53 / and UPK10. …
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Variabilität molekularer axialer Differenzierung am Beginn der Gastrulation beim Kaninchen
… Schlüsselgenen der frühen Achsenentwicklung Dkk1, Cer1, Lefty und Hex untersucht. Für die Untersuchungen wurde das Kaninchen als Modellorganismus ausgewählt, weil es mit seiner flachen Keimscheibe für den Säugerembryo in besonderer Weise repräsentativ und durch seine späte Implantation für …
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Genetic Pathway Analysis of Abnormal Facial Development In Nonsyndromic Cleft Lip and Palate
… FZD6</em>, <em>LRP5</em>, <em>LRP6</em> and <em>DKK1 </em>driving allele-specific expression during craniofacial development. Testing of these variants in our extensive family-based NSCLP dataset identified, for the first time, associations between <em>LRP5</em> and <em>DKK1</em> and NSCLP, and …
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Wnt Signals and Imaging Tissue Renewal in the Human Colonic Epithelium
… exposure due to the presence of its antagonist Dkk1. From these observations, it was possible to determine the effect of Wnt signalling on crypt cell kinetics. Results Cell proliferation and canonical Wnt signalling pathway activity predominated at the base of native human colonic crypts. …
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The Role and Control of WNT Signalling in an HESC Model of Human Primitive Streak
… CRISPR/Cas9 knockout lines, I discovered that DKK1 and E-CADHERIN were the two dominant factors, with E-CADHERIN transducing boundary forces to focus WNT signalling to colony border at early times, and DKK1 controlling the late WNT pattern via cell non-autonomous negative feedback. With the …
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Der Wnt-Signalweg in der Makrophagen-induzierten Invasion von Brustkrebszellen
… Durch den physiologischen Wnt-Antagonist Dkk1 war eine Inhibition sowohl des Makrophagen-abhängigen Ko-Kultur-Effekts als auch der Wnt-5a-bedingten Invasivität der Tumorzellen erreichbar. In den MCF-7-Zellen war ein intakter kanonischer, d.h. β Catenin abhängiger, Wnt-Signalweg eine …
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Effects of early nutrition on the wnt and bone morphogenic protein pathways in the developing intestine
… of β-catenin, sFRP3, sFRP4, frizzled 6, DKK1 (Wnt pathway), gremlin (BMP pathway), TNF-a, HNF-4α and osteopontin (OPN) was measured by RT-qPCR. Piglets fed the F+P diet had greater acetate concentration and lower pH in the ileum at day 14 and in the colon at day 7 and day 14 than F …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… inhibition of canonical Wnt signaling with Dkk1 leads to a rapid loss of TEC progenitors as well as a decline in mature Aire-expressing mTECs. Therefore, we explore the role of Wnt ligands potentially responsible for stimulating and/or regulating Wnt signaling in TECs by analyzing the …
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Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking
… with the invasive phenotype such as RHOB and DKK1, and networks associated with cell motility such as integrinlinked kinase signaling, and focal adhesion kinase signaling. AREG was also found to modulate WNT and Notch signaling in SUM-149 cells. In an additional microarray study, changes in …
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Genotipagem e análise da expressão do gene TCF7L2 em pacientes com alteração do crescimento fetal e doenças metabólicas no adulto.
… genes e produtos relacionados à via Wnt, como DKK1, CTNNB1, GCG, APOE, APOC1 e FTO. Estas moléculas participam da regulação via Wnt e do metabolismo de carboidratos e lipídeos. Dessa forma, TCF7L2 parece influenciar o peso ao nascer, o que contribui ao desenvolvimento de SMet e obesidade na …
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microRNA expression profile of undifferentiated and differentiating pluripotent cells
… sind. Zwei dieser Zielgene, Smad2 und Dkk1, wurden experimentell untersucht, scheinen aber keine Zielgene des miR-302 Clusters zu sein.
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SIGNALLING TISSUE RENEWAL AND CRYPT SURVIVAL IN THE HUMAN COLONIC EPITHELIUM AND BARRETT’S OESOPHAGUS
… signals also rescued the inhibitory effects of Dkk1, IWP2 and dnTCF4 on Wnt target gene expression, cell proliferation and crypt length. BMP and TGFβ inhibited Wnt target gene expression, cell proliferation and crypt length. A near-native human Barrett’s oesophagus ex vivo culture model was …
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Development and Maintenance of the Thymic Epithelial Microenvironment
… epithelial architecture. Overexpression of DKK1, a Wnt inhibitor, leads to loss of thymic progenitor and rapid thymic degeneration in the thymus. Thus, Wnt signaling has involved the maintenance of adult thymic epithelial progenitor cells. Therefore, we hypothesized Wnt signaling could also …
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Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
… the emergence of GATA6 cells in either IWP-L6 or DKK1(two inhibitors of WNT signalling). WNT signalling governs hypoblast- but not trophoblast-like cell differentiation in HNES cells. The blockade of FGF receptors using potent inhibitors derails differentiation and in combination with LIF can …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… could enhance the anabolic effects of anti-Dkk1 therapy. Using a genetic mouse model with constitutive embryonic deletion of <italic>Smad4</italic> in <italic>Osterix+</italic> cells, we instead find that long-term deficiency of <italic>Smad4</italic> in <italic>Osterix+</italic> cells …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… treatment with recombinant human Dickkopf-1 (rhDKK1) protein, or transgenic expression of Xenopus DKK1, did not significantly affect the percentage of successful regeneration. Together, these results suggest a model where Wnt/β-catenin signaling is active in the larval cornea epithelium and …