Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Division of Bioengineering and Environmental Health."”.
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The spontaneous mutational spectrum of exon 2 and the high melting region of exon 3 of the human HPRT gene
Thesis (S.M.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 1999.
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A comparative analysis of age-dependent and birth year cohort-specific cancer mortality data between Japan and the United States
Thesis (S.M.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 1999.
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The role of polyphosphate kinase in long term survival of Helicobacter pylori
Thesis (S.M.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 1999.
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The role of base excision repair proteins in the cellular responses to the anticancer drug cisplatin
Thesis (Ph.D.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 2000.
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A technology for detecting unselected mutational spectra in human genomic DNA
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 1999.
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Determination of the historical changes in primary and secondary risk factors for cancer using U.S. public health records
… cancer mortality rates have risen from about 4% of all deaths in the early 20th century to about 25% of all deaths by the end of the century in the United States. To assess any potential hypotheses for this increase required knowledge of the mortality rate changes specific to each form of cancer, …
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A clamp ligation method for point mutational spectrometry : marked increase in scanning range for the human genome
The study of human mutagenesis requires methods of measuring somatic mutations in normal human tissues and inherited mutations in human populations. Such methods should permit measurement of rare mutations in the presence of abundant wild-type copies and should be general to the human genome. A …
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Sequencing complex polysaccharides
… information-dense molecules are key regulators of extracellular signals. However, to date, there has been a lack of effective biochemical and analytical tools for the analysis of glycosaminoglycan structure and hence, there is very little understanding of exactly how glycosaminoglycan structure …
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Nitric oxide : cellular effects in vitro and in vivo
The overall aim of this project was to investigate various cellular responses and toxic effects of nitric oxide, NO' and in vitro and in vivo. Nitric oxide gives rise to a complex spectrum of reactive species in oxygenated solution. The complexity of nitric oxide's chemistry is recapitulated in its …
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Analysis of community cancer mortality rates
Residents of small communities or neighborhoods often observe what appears to them to be an excessively high number of cancer cases. Some of these observations are brought to the attention of public health officials in the hope that an environmental cause within these communities may be discovered …
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Genetic requirements for protection against bleomycin toxicity in Escherichia coli
Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare the relative sensitivities of a wild type Escherichia coli strain to a panel …
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The toxicity and mutagenicity of the aflatoxin B₁ formamidopyrimidine DNA adduct
… contaminates the food supply in certain areas of the world. It is produced by Aspergillusflavus and related fungi that grow on improperly stored foods such as corn, rice, and peanuts. Epidemiological studies have shown a correlation between exposure to AFBI and incidence of hepatocellular …
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Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
… found both in extracellular matrix (ECM) and at the cell surface where they, in a sequence-specific manner, bind to and regulate the biological activity of numerous proteins. Due to a lack of effective tools to study structure-function relationship of these complex molecules, the role(s) …
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Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins
… agent, Tamoxifen, have had only limited success, often showing uncomfortable side effects. Our group has proposed a new scheme for a rational drug design. This scheme utilizes recent findings on the mechanism of cisplatin, the drug found to cure in excess of 93% of all testicular cancer cases. …
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Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy
Quantification of adducts in human samples is a challenging task in analytical chemistry. Humans are typically exposed to low levels of a wide range of different carcinogens. As a result, adduct quantification requires both a highly sensitive and a highly selective method. This project has focused …