Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Dividing cells"”.
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Ribonucleotide reductase in dividing cells: Purification and inhibition studies with 4-hydroxynonenal
… rat liver, regenerating liver and hepatoma (cells), while the enzyme activity was undetectable in adult rat liver and sham-operated rat liver. The enzyme activity in Yoshida cells was 3-fold of the activity in Morris 5123tc tumours. Dithiothreitol (DIT) activated the activity of CDP reductase …
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Genetic requirements for protection against bleomycin toxicity in Escherichia coli
… bleomycin. This sensitivity was tested in both dividing and non-dividing cells in order to analyze the effect of cell division on the cytotoxicity of bleomycin. When non-dividing cells were treated, the recBCD and recGruvC mutants, demonstrated high sensitivity to bleomycin. The recF mutant, on …
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Seasonal and Diel Patterns of Abundance and Productivity of Phototrophic Picoplankton in the Lower Chesapeake Bay
… microscopy ranged from 7.26 x 10<sup>6</sup> cells/1 in the winter to 9.28 x 10<sup>8</sup> cells/1 during late summer.</p> <p><em>In situ</em> incubations of natural picoplankton populations over the 15 month study were used to test the applicability of the frequency of dividing cells …
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Specific, Reversible Cytostatic Protection of Normal Cells Against Negative Effects of Chemotherapy
… cancer chemotherapeutics target proliferating cells and tissues, all dividing cells, whether normal or tumor, are affected. Cell culture studies have demonstrated that UCN-01 is able to reversibly and selectively arrest normal dividing cells; tumor cells lines do not undergo this temporary …
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The instructive roles of muscle cells in planarian regeneration
… and to indefinitely maintain tissue homeostasis. Dividing cells, neoblasts, are the source of all new tissue, whereas positional information is hypothesized to be harbored by post-mitotic muscle, including the subepidermal body wall musculature. Single-muscle-cell mRNA sequencing along the …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
Chemotherapy and radiotherapy target neoplastic cells. However, they also adversely affect progenitor cells throughout the healthy alimentary tract, resulting in severe ulceration and pain. This affects around 500,000 patients annually. The aims of the present research were to identify the main …
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Dynamics of Germ Cell Specific Stable Transcriptional Complexes in Xenopus Oocytes
… significantly prolonged in stably differentiated cells, as are most non-dividing adult cell types? I have investigated the dwell time of the neurogenic transcription factor Asc1-1 by injecting mRNAs or DNAs into the non-dividing oocyte of Xenopus. Transcription factor proteins can be introduced by …
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Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea
… and affordably for tens of thousands of single cells, raising the possibility that transcriptomes could be generated for all cell types and cell states in a complete animal. Planarians are freshwater flatworms renowned for their capacity for whole-body regeneration. They possess a complex body …
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Supramolecular anticancer agents and their effects on cells and biomolecules
… relevant to the DNA replication fork, present in dividing cells. Chapter four outlines a number of novel in vitro studies on an iron supramolecular cylinder which indicate new, unsuspected and unprecedented biological actions. In chapter five biological studies of unsaturated ruthenium(II) …
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Nutritional status dictates the rate and mode of intestinal epithelial stem cell proliferation through an AMPK dependent mechanism
… size by increasing the number of epithelial cells, villi height and crypt depth. Because increases in tissue size are under the control of stem cells located within the tissue, I investigated if and how the amount of food may drive increases in the rate and mode (asymmetric vs. symmetric) of …
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Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry
… thymidiie analogue that incorporates into DNA of dividing cells during the S-phase of the cell cycle. Previous work in laboratories reported that treatment with lOyM BrdU in the human lung carcinoma cell line (DLKP) resulted in increased expression of the cytoskeletal proteins Keratin 8 and 18 and …
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Mechanisms of tissue-specific regeneration in planarians
… this ability is a pluripotent population of dividing cells called neoblasts, which are required for homeostatic maintenance and regeneration of all planarian tissues. Whether neoblasts restore proportion by sensing and responding to the presence or absence of specific tissues during …
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Effects of the conserved proteins, Soj (ParA) and SpoOJ (ParB) on chromosome partitioning in Bacillus subtilis
… Faithful chromosome partitioning is important to dividing cells because anucleate, or chromosomeless, cells are not viable. Since the discovery of the Par system in low-copy number plasmids over 20 years ago, research has focused on characterizing its components: ParA, a DNA-binding ATPase, ParB, …
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An inducible, conditional and targeted B cell ablation mouse model for studying B cell functionality in the pathogenesis of human diseases
… ablation using HSVtk transgenic mice eliminates dividing cells, but does not affect non-dividing cells. In addition, because of its extremely high potency (a single molecule of DT-A, the active cleavage product of DT is sufficient to induce apoptosis), dose dependent responses are difficult to …
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The evolution of neuronal progenitor cell division in mammals: The role of the abnormal spindle-like microcephaly associated (Aspm) protein and epithelial cell polarity
… proliferative divisions of neuroepithelial (NE) cells was analyzed. It was found that Aspm expression in the mouse neuroepithelium correlates in time and space with symmetric, proliferating divisions. The Aspm protein localizes to NE cell spindle poles during all phases of mitosis, and is …
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Brain regeneration in a hypoxic-ischemic mouse model
… HI brain injury neurons, glia and endothelial cells are damaged and lose their function or die. But unexpectedly there are greater numbers of infants do not suffer lasting neurological impairment. One of the reasons may be the formation of new cells in the damaged tissue. Hypoxic ischemic …
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The biological properties of three trichothecene mycotoxins produces by fusaris
… lesions observed were atrophy of the actively dividing cells of the bone marrow, thymus, spleen and lymph nodes. The reported species difference in T-2 toxin toxicity was investigated by determining the deacylation rate of T-2 toxin to HT-2 toxin, one of the first steps in the detoxification of …
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P16/INK4a controls the morphology program associated with cellular senescence
… Cellular senescence is a state which normal cells enter following an extensive period of proliferation or upon exposure to various kinds of stress. The senescence program involves G1 arrest accompanied by dramatic changes in cell function and morphology. The molecular mechanisms that govern …
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Protein engineering for targeted delivery of radionuclides to tumors
… is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery only target known cancer sites. However, targeted therapeutics, such as antibodies, will bind to all cancer cells that express the targeted antigen, including small metastases that are invisible by …
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