Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"Diversity Oriented"”.
-
Fragment synthesis: pharmacophore and diversity oriented approaches
… in fragment screening libraries a number of diversity-orientated synthetic campaigns were undertaken. The first of these utilised glycine as starting material. Two terminal alkenes were installed. The alkenes were linked and the amino and acidic residues cyclised. This allowed for the …
-
Diversity oriented, computer guided catalyst design: Application of chemoinformatics to catalysis
… 3) focus on the development and application of a diversity oriented, computer guided catalyst optimization chemoinformatic workflow. This process seeks to combine the power of chemoinformatic diversity analysis and QSAR modeling with diversity and discovery oriented synthesis to rapidly and …
-
Novel Photochemical Methodologies for Diversity Oriented Synthesis and Screening of Combinatorial Libraries
… a rapid increase in molecular complexity and diversity of the target scaffolds.</p> <p>To develop this novel methodology further and explore its generality, we directed our attention to the <em>Diels-Alder</em> adducts based on various chromones. We discovered that the <em>Diels-Alder</em> …
-
A Diversity-Oriented Synthesis Approach to Functionalized Azaheterocycles using Cyclic Alpha-Halo Eneformamides
… a step-economical, cost-effective, scalable, and diversity-oriented synthesis approach to highly functionalized N-heterocycles through the intermediacy of α-halo enamines/enamides. The synthetic utility of the method is exemplified through the construction of quaternary cyclic propargylic and …
-
I. Microwave-Influenced Diversity-Oriented Synthesis Of Biologically Relevant Small & Natural-Product-Like Molecules Via Multicomponent Coupling Reactions Ii. Synthetic Studies Toward The Total Synthesis Of The Repeating Tetrasaccharide Unit Of Zwitterionic Polysaccharide Ps A1
<p>Microwave-influenced diversity-oriented synthesis of biologically relevant small and natural-product-like molecules via multicomponent coupling reactions (MCCRs) have been investigated. Cheap, readily available starting materials in conjunction of microwave irradiation and employment of …
-
SYNTHESIS OF NOVEL BODIPY LIBRARIES AND THEIR APPLICATION IN BIOIMAGING
… applied a combinatorial approach to construct diversity-oriented fluorescent libraries as chemical tool box based on BODIPY fluorophore. These novel BODIPY libraries were then carried out in both unbiased in vitro screening and cell-based screening systems. Novel sensors towards fructose, …
-
An Exploration of Leadership and Campus Cultural Orientation In a California Community College
… leadership was employed to create a diversity oriented campus culture that was leading toward an equity oriented campus culture. Self-leadership and a awareness of the campus culture were essential to transformational leaderships implementation.</p>
-
Development of decarboxylative strategies towards the synthesis of fluorinated pharmacons
… Over the past few decades, fluoro(oxo) diversity has been accessed through oxidation state manipulations from the parent trifluoromethyl ketone, either by carbonyl reduction to give the trifluoroethanol or elimination to yield the difluoromethyl ketone. As such, synthetic chemists are …
-
Cascade Annulation and Ring-Opening Reactions of Castagnoli-Cushman-Derived Allylic and Benzylic Thiomorpholinonates
… approach taken to achieve this goal is to employ diversity-oriented synthesis (DOS), which produces diverse complex molecules with similar core structures from a common precursor. When a DOS features a cascade or domino reaction in the key steps, the process becomes even more cost- and …
-
HYPERVALENT IODINE-MEDIATED HETEROCYCLIC GROUP TRANSFER REACTIONS TO OXIDATIVE OLEFIN DIFUNCTIONALIZATION
… salts to be viewed as a synthetic platform for diversity-oriented amine synthesis. Chapter 4 will elaborate on the synthesis of different classes of 3-aminopiperidine motifs using hypervalent iodine reagents; these motifs have been previously synthesized using transition metal catalysis.
-
To Design and Develop Semi-Saturated and Unsaturated Bicyclic Heterocycles for Fragment-Based Drug Discovery (FBDD) Campaigns
… the concept of reagent- and scaffold-based Diversity-Oriented Synthesis (DOS). This approach was undertaken on three privileged heterocycles, armed with two key functionalities for the bicyclic construction.<br/><br/>Chapter 3 discusses the application of diverse chemistry to construct …
-
Synthesis and antibacterial evaluation of diverse small molecules
… First we extend organocatalysis to the field of diversity-oriented synthesis as a powerful means to generate molecular diversity and complexity in small molecule screening collections. We then study a family of potential biofilm inhibitors identified from a diverse screening collection, and for …
-
Design and Synthesis of Antimycobacterial Agents
… more chemical space. After its extensive work in diversity-oriented synthesis, the Spring group has developed such a library. A collection of these compounds was evaluated in a phenotypic screen against *Mycobacterium abscessus*, producing four lead compounds, two of which, **13H8** and **14F8**, …
-
Exploration of [2+2+2] cyclotrimerisation reactions of alkynes. A new methodology for the synthesis of small molecules to probe biological systems
… for diversification were synthesised using a diversity-oriented synthesis approach; specifically the build/couple/pair strategy for the synthesis of small molecules. Racemic nitrogen and oxygen building blocks were coupled with acrylonitrile, bromoacetonitrile and acyl chlorides. The pair step …
-
Exploration of [2+2+2] cyclotrimerisation reactions of alkynes. A new methodology for the synthesis of small molecules to probe biological systems
… for diversification were synthesised using a diversity-oriented synthesis approach; specifically the build/couple/pair strategy for the synthesis of small molecules. Racemic nitrogen and oxygen building blocks were coupled with acrylonitrile, bromoacetonitrile and acyl chlorides. The pair step …
-
OPENING NEW CHEMICAL SPACE IN DRUG DISCOVERY
… size is not decisive, the concept of library diversity, in terms of molecular structure and, more importantly, molecular function, has become crucial, making the efficient creation of functionally diverse small molecule collections a formidable challenge. When a specific biological target is …
-
I. Catalyst development in asymmetric phase transfer catalysis employing QSAR methods II. Computational investigations on the stereochemical course of the addition of allylsilanes to aldehydes
… of the quaternary ammonium ions follows a diversity oriented approach wherein the tandem inter[4+2]/intra[3+2] cycloaddition of nitroalkenes serves as the key transformation.. Catalyst activity and selectivity are rationalized in a qualitative way based on the effective positive potential …
-
Leveraging large language model embeddings to enhance diversity and mitigate the filter bubble effect in recommender systems
… to effectively isolate individuals from a diversity of perspectives or content. In particular, this filter bubble effect may appear as a result of recommender systems used on social media platforms or online marketplaces to influence user behavior. While customization may improve user …
-
Synthesis of Partially Saturated Bicyclic Heteroaromatics: sp3-Enriched Scaffolds for Drug Discovery
… and have identified the lack of scaffold diversity and poor physicochemical properties in screening libraries as the leading causes. In an attempt to address this issue drug discovery strategies such as fragment-based drug discovery and lead-oriented synthesis have been developed which …
-
Photoassisted Synthesis of Complex Polyheterocycles via Rational Design of Tailored Photoprecursors
… the most common source for drug leads, although diversity-oriented synthesis of unnatural complex molecules is gaining momentum. Our lab has been developing experimentally simple and straightforward approaches to complex molecular architectures via photochemical reactions involving a minimal …
Page 1 of 2