Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Diterpenoid"”.
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… We then analysed the long term effect of the diterpenoid compound EOF2, a PKC activator known to promote cell migration and differentiation. EOF2 treatment enhanced the recruitment of SVZ derived neuroblasts toward the lesion. Newly generated neurons exhibited progressive electrophysiological …
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Total synthesis of Dan Shen diterpenoid quinones ; Synthesis and chemistry of (triakylsilyl)vinylketens
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Indole diterpenoid secondary metabolites produced by the Epichloë festucae var. lolii – Lolium perenne symbiosis.
The indole diterpenoid intermediates of lolitrems in a crude extract of Lolium perenne (L. perenne) seed infected with Epichloë festucae var. lolii (E. festucae var. lolii) and their biological activity against porina larvae were investigated. Liquid-liquid partitioning of the crude extract, …
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Cyclodextrin Assisted Enantiomeric Recognition of Amino Acid Imides and Toward Synthesis of Dolabellane Diterpenoid B
… constants of this host-guest system. Dolabellane diterpenoids share the unique feature of a trans-bicyclo[9.3.0]tetradecane and most of them express antimicrobial, antitumor and antiviral activities. They are primarily obtained from marine resources. Dolabellane diterpenoid B was isolated from the …
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Complex botanical natural products: Synthesis of cephalotaxus esters and of the C19-diterpenoid skeleton of aconitum and delphinium alkaloids
… completed synthesis of the skeleton of the C19-diterpenoid alkaloids is described. Key steps include a Diels–Alder cycloaddition of a cyclopropene with a 2,5-dioxycyclopenta-1,3-diene, a second Diels–Alder cycloaddition with a 2,5-dihydroazepine 2π component, an intramolecular N-acyliminium …
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Investigation of cytochrome P450s in the biosynthesis of rice phytoalexins
… almost invariably belong to the labdane-related diterpenoid (LRD) superfamily. The phytoalexins identified in rice thus far are momilactones A-E, phytocassanes A-F, oryzalides A and B, oryzalexins A-F, oryzalexin S, ent-10-oxodepressin and sakuranetin, all of which but the last two are LRDs. An …
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Terpenoid metabolites from three dorid nudibranchs and a new bromotryptamine derivative from the Northeast Pacific sponge Plocamissa igzo
… Lanka were found to contain the known spongian diterpenoid 34 aswell as the new metabolites 61 and 62. A study investigating the geographical variation in the metabolites present in Cadlina luteomarginata along the British Columbian coast revealed the drimane sesquiterpenoid albicanylacetate …
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Investigating factors that influence microalgae production platforms for diterpenoids in laboratory and outdoor conditions
… had previously been engineered to produce the diterpenoid, casbene, by introduction of the *Jatropha curcas* gene encoding casbene synthase. Two constructs were used, PM50, where the casbene synthase gene is under the control of the HSP70/RBCS2 promoter and includes a chloroplast transit …
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Total Synthesis of Maoecrystal V
… toward Maoecrystal V, a potential anti-cancer diterpenoid. Maoecrsytal V was isolated in 2004 from a Chinese herbal medicine. It has a highly congested structure, in which there are three continuous quaternary carbon center embedded within a rigid pentacyclic scaffold. The first chapter of this …
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Pleuromutilin and its Application Towards Bidentate Antibiotics: Triazoles, Linker Chemistry, and Serendipitous Discoveries
… pleuromutilin antibiotics constitute a class of diterpenoid, ribosome-inhibiting antibiotics. Pleuromutilins have been developed into a number of veterinary antibiotics, as well as two FDA approved drugs, retapamulin and lefamulin. This class exhibits a low propensity to resistance development. …
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Studies on the chemistry of taxol
The novel diterpenoid taxol isolated from the western yew Taxus brevifolia is one of the most important lead compounds to emerge from the search for anticancer agents from plants. It shows consistent clinical activity against ovarian cancer and may also be active against other cancers. In this …
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Towards a Formal Total Synthesis of Triptolide Via a Gold-catalyzed Cyclization Cascade
… synthesis of triptolide, a naturally occurring diterpenoid triepoxide molecule. Isolated from a Chinese vine, triptolide features some interesting structural characteristics and has demonstrated a broad range of interesting medicinal effects. It has demonstrated remarkable cytotoxicity against a …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
… pharmacophore: salvinorin A — a neoclerodane diterpenoid natural product isolated from Salvia divinorum. Salvinorin A represents a pharmacologically unique compound in that it is the first known non-nitrogenous KOR subtype-selective agonist, exhibits a comparatively safe physiological profile …
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Construction of carbocycles via oxonium ylides generation and rearrangement: towards the synthesis of taxol
The diterpenoid natural product Taxol, first discovered in the late 1960’s, is one of the most important current drugs for the treatment of several cancers including breast and ovarian cancers. Although tremendous efforts towards its synthesis have been made in the last two decades, resulting in …
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New purinergic-based pharmacological targets for the treatment of retinal disorders
… by the computational analysis revealed that the diterpenoid dihydrotanshinone (DHTS) clustered with the well-known P2X7R antagonist JNJ47965567 (used as a positive P2X7R antagonist control in my experiments). In order to assess the potential protective effect of DHTS (as a possible P2X7R …
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The application of nuclear magnetic resonance in the structural elucidation of natural products
… the opium alkaloids codeine and papaverine, the diterpenoid alkaloids delphinine and aconitine and the triterpenoid derivatives of cucurbitaceae. One dimensional NMR spectroscopy viz 1H, 13C and Distortionless Enhancement by Polarisation Transfer (DEPT) spectroscopy was initially applied to …
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The chemistry of cephalomannine
Cephalomannine is a naturally occurring taxane diterpenoid closely related to the potent anticancer agent Taxol. Three aspects of its chemistry were examined. First, cephalomannine was converted to Taxol. This conversion was accomplished by the reaction of a 2'- benzoyl-7-Troc cephalomannine/Taxol …
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