Global ETD Search
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Showing 1 to 20 of 30 for “"Diterpenes"”.
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The Stereochemistry and Mechanism of The Biosynthesis of Ent-Sandaracopimaradiene and Related Diterpenes
The stereochemistry and mechanism of the cyclization of copalyl pyrophosphate to (+)-sandaracopimaradiene by enzyme extracts from R. cummunis was investigated. (S)-Geranyl-geraniol-1-d was prepared by enzymatic reduction of geranyl-geranial-1-d with horse liver alcohol dehydrogenase and NAD('+) …
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Isolation, Characterization, and Molecular Modeling Studies on Diterpenes From Marine Organisms Withing the Eunicea Genus
Mass spectrometry was used in conjunction with numerous 1-D and 2-D NMR techniques to determine the structures, devoid of stereochemistry, of five different compounds isolated from the extracts of Eunicea succinea, Eunicea tourneforti, and an unidentified species isolated from the Eunicea genus by …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… as a source of secondary metabolites, mainly diterpenes. Exhaustive studies of the spectroscopic and spectrometric data were explored following two basic axes: 1- Phytochemical investigation : Phytochemical investigation on latex of Euphorbia resinifera led to the ísolation and identification …
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Diterpenos com atividade antitumoral frente células leucêmicas: uma revisão.
… this study is to review the action of antitumor diterpenes against leukemic cells from a survey of data about their activi ties in experimental procedures . In this review , it was list ed 862 in vitro studies of diterpenes against leukemic cells from 27 different lineages, with 84.7% of …
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Searching for Anticancer Natural Products From the Rainforest Plants of Suriname and Madagascar
… led to the isolation of six new clerodane diterpenes. Four were new natural products and the other two were previously unreported hydrolysis products. Their structures were determined using mass spectrometry and 1-D and 2-D NMR. All six compounds were cytotoxic in the A2780 human ovarian …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… culinary and medicinal herb abundant in diterpenes, understudied antioxidant and anti-inflammatory phytochemicals. Carnosic acid (CA) and carnosol (CL) are the most abundant diterpenes in rosemary, however less abundant diterpenes are understudied. Fractions that excluded CA and CL from …
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Isolation, Characterization, and Synthesis of Bioactive Natural Products from Rainforest Flora
… and analysis with standards by GCMS. Two new diterpenes were isolated from Hymenaea courbaril, which in an earlier investigation provided a new diterpene. The absolute configurations of these diterpenes were assigned on the basis of anisotropic NMR studies, X-ray crystallography, circular …
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Ι. ΜΕΛΕΤΗ ΤΩΝ ΧΗΜΙΚΩΝ ΣΥΣΤΑΤΙΚΩΝ ΤΟΥ ΦΥΤΟΥ CISTUS INCANUS SUBSP. CRETICUS (L.) HEYWOOD ΙΙ. ΑΠΟΜΟΝΩΣΗ-ΔΟΜΗ-ΣΥΝΘΕΣΗ ΝΕΟΥ ΦΛΑΒΟΝΟΕΙΔΟΥΣ ΤΟΥ ΦΥΤΟΥ KALANCHOE PROLIFERA R. HAMET
… EXTRACT AND ETHER EXTRACT SEVEN LABDANE -TYPE DITERPENES HAVE BENEN ISOLATED AND IDENTIFIED. THE STRUCTURES OF ALL THE COMPOUNDS WERE DETERMINED BY MS (EI), (CID), H-NMR. FROM THE 95% ALCOHOL EXTRACT WERE ISOLATED SEVEN POLYPHENOLIC SUBSTANCES. INTHE SECOND PART OF THIS THESIS WERE STUDIED THE …
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Enantioselective Conjugate Additions to a Hindered Cyclohexenone System
… systems. The framework of multiple tetracyclic diterpenes has also been achieved through chiral auxiliary removal on the Friedel-Crafts products followed by regioselective enol silane formation and palladium-catalyzedcycloalkenylation<sup>4,5</sup> to form the bicyclo[3.2.1]octane core.</p>
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A Concise, Stereocontrolled Total Synthesis of Rippertenol
Rippertenol and the kempane diterpenes are biogenetically derived from cembrene A and are dense with stereochemical complexity despite a paucity of heteroatom functionality. A discussion of past synthetic efforts towards these complex targets is presented to define the current level of …
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Synthesis of the Ophiobolin Ring System
… configuration of the fusicoccin family of diterpenes at C-6, C-7, and C-11 was also synthesized by the same annelative two-carbon ring expansion of an unsubstituted trans-hydrindanone. Analysis of the chemistry of these 5-8-5 ring systems was simplified since most chemical transformations …
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Enhanced yield of medicinal products from Tripterygium cell cultures
… Yield improvement for the triptolide family of diterpenes (triptolide and tripdiolide) was approached through the synthesis of potential intermediates of the natural biosynthetic pathways, the first step in a technique where synthetic elaborations would be completed by cell cultures. These …
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Isolation and biological characterisation of plant-derived chemicals for antibacterial purposes in food animals and humans
… Aframomum melegueta three of which are labdane diterpenes; two of these diterpenes, G3 and G5 were significantly (p <0.05) more potent than either ampicillin or gentamicin when combating Grampositive bacteria. The fourth compound (plasticizer) showed activity only against Gram negative E.coli …
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Investigating the evolution of cytochromes P450 involved in GA biosynthesis
… on C19, AtKO reacts with labdane-related diterpenes of varied stereochemistry, which further leads to altered hydroxylation regiochemistry. Our results demonstrate greater promiscuity of AtKO, which evolved in the absence of other potential labdane-related diterpene substrates, relative to …
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Synthetic studies utilizing podocarpic acid
… Common and Systematic Nomenclature of Cyclic Diterpenes', 3rd Revision, Oct. 1968, to be submitted to the IUPAC Commission on Organic Nomenclature has been prepared from 12-hydroxypodocarpa-8,11,13-trien-19-oic acid (1), via the C4 ketones (76) and (77). Both of these isomers were obtained …
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Antibacterial, antioxidant and phytochemical investigation of Albizia Anthelmintica leaves, roots and stem bark
… revealed the presence of alkaloids, saponins and diterpenes in roots and bark extracts, flavonoids in leaves extract, tannins in roots extracts, and phenolic compounds were detected in all three extracts. The root extract exhibited the highest total phenolic and flavonoid content of 1741.08 ± 0.05 …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… modulate endogenous neurogenesis and identifies diterpenes as promising candidates for therapeutic strategies aimed at promoting neuronal regeneration and functional recovery after cortical injury.
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Functional separation of the biphasic actions of ryanodine
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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