Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Disuse"”.
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The role of osteocytes in disuse and microgravity-induces bone loss
… for treatment of bone disorders related to disuse or immobilization. Thus, we conducted in vitro and in vivo studies on osteocytes exposed to unloading to investigate their role in disuse and microgravity-induced bone loss. Specifically, we generated and characterized a novel osteocytic cell …
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Transcriptomic Signatures of Skeletal Muscle Adaptation: Disuse, Rehabilitation, and Resistance Exercise Intervention
… we first aimed to elucidate the effects of disuse on the skeletal muscle transcriptome and map the molecular time course of rehabilitation. By employing transcriptomic analyses, we identified key molecular pathways altered following disuse, including mitochondrial function, apoptosis, immune …
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Development of an extracellular vesicle therapy to recover skeletal muscle after disuse
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Comprehensive analysis of cellular contribution to delayed skeletal muscle recovery after disuse
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Numerical Study of Nutrient Mixing in Trabecular Bone in Microgravity, Disuse and Normogravity
… frequencies to represent microgravity or disuse, walking, and running conditions. Scalar concentration decay is quantified using the spatial root-mean-square metric and fitted with a bi-exponential model representing diffusive and convective mixing phases.</p> <p>Results show that nutrient …
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Development of a pericyte-based strategy to recover aged skeletal muscle after disuse
Skeletal muscle disuse atrophy is the decline of muscle mass that occurs after periods of extended bed rest or immobilization. Recovery via physical rehabilitation is often incomplete in special populations such as older adults, due to injury and pain, functional limitations, and anabolic …
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Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle
Skeletal muscle health is highly dependent on the intricate mitochondrial reticulum that exhibits high levels of adaptability. It is now recognized that mitochondrial perturbations can activate innate immune pathways, such as the NLRP3 inflammasome complex, by augmenting the response against …
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Disease, Disuse, and Disappointment: The Volunteer Experience and the Modernization of the American National Guard, 1898-1902
This dissertation combines an intimate study of the common volunteers during the Spanish American War with a look into larger institutional changes within the American military at the turn of the Twentieth Century and the development of a modern National Guard. The Spanish American War left a …
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Sex-Based Differences in ACVR2B and GRB10 Expression in Skeletal Muscle During Induced Cancer Cachexia and Disuse
… atrophy disorders such as cancer cachexia and disuse. These forms of muscle atrophy produce distinct wasting pathologies that are influenced by biological sex. Activin receptor type-2B (ACVR2B) and Growth factor receptor-bound protein 10 (GRB10) have been identified as genes that potentially …
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Development of a stem cell-based therapy for the recovery of skeletal muscle mass following immobilization
Skeletal muscle disuse atrophy is a debilitating medical condition that occurs as result of limb immobilization and whole body bed rest. Severe reductions to muscle mass contribute to functional declines, disability, and metabolic comorbidities, such as obesity, Type II diabetes, and cardiovascular …
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The Effects of Denervation and Arterial Ligation on Calcium Turnover in Bone
… being osteoporosis. Regardless of its etiology (disuse, post-menopausal, Cushing's syndrome, old age and others), osteoporosis is characterized by decreased bone substance per unit volume of bone. Microscopically, the bone that remains is essentially normal but new bone formation is usually not …
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Osteocyte Activity and Skeletal Muscle Relative Gene Expression Profiling After Short-term Muscle Paralysis
… on bone, and can result in the development of disuse osteoporosis. Disuse models of muscle inactivity and immobilization, like the Botox model used in this study, result in changes in the bone microarchitecture, the mechanisms behind which are not fully understood. In a previous four-week Botox …
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Development of a pericyte-derived extracellular vesicle therapy for the recovery of skeletal muscle mass following immobilization
… and skeletal muscle mass, a condition known as disuse atrophy. Physical therapy is standard practice following disuse atrophy and may be sufficient for complete recovery of muscle mass and function in young individuals. However, the majority of older adults are not able to fully engage in a …
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The Role of Wnt Signaling in Bone Mechanotransduction
… among other functions. During periods of disuse, β-catenin is degraded, leading to inhibition of Wnt targets. Here, I characterize the role of β-catenin in bone during a disuse challenge, using a genetic mouse model expressing an inducible constitively-active mutant form of β- catenin in …
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Effect of Denervation on the Regulation of Mitochondrial Transcription Factor a Expression in Skeletal Muscle
… content during denervation, a muscle disuse model, occurs during the first week following the onset of the stimulus. In this study, we analyzed the expression of Tfam, a critical mitochondrial transcription factor involved in the orchestration of mitochondrial biogenesis, at multiple …
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A dynamic supine stander for subjects with disabilities leading to prolonged immobility
… in resorption of bone by osteoclast cells. This disuse modeling can lead to osteopenia, osteoporosis, and subsequent non-traumatic fractures. These disabilities are varied in nature and duration, and can include load bearing bone fracture, excessive obesity, spinal cord injury, and cerebral …
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The assessment of the rheumatoid hand : "the assessment of the function of the hand undergoing corrective surgery for rheumatoid disease using specially designed biomechanical instruments and the Colour Television Image Analyser"
… closely related in both the hypodynamic state of disuse and the hyperdynamic state of improved function following corrective surgery.
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Imifino yasendle, imifino isiZulu : the ethnobotany, historical ecology and nutrition of traditional vegetables in KwaZulu-Natal
… thought that these plants are falling into disuse as food preferences change and exotic vegetables such as spinach or cabbage become more commonly available. This report aims to provide basic understandings to inform the promotion of traditional vegetables in South Africa by exploring their …
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Monitoring and evaluation of household water treatment and safe storage technologies : the sustained use of the KOSIM ceramic water filter in northern region Ghana
… the factors that contribute to sustained use or disuse. I also conducted water quality analysis using the Colilert® and the 3MTM PetrifilmTM tests to evaluate the performance of the KOSIM filter in the field. Forty-six percent of PHW's rural customers were still using the KOSIM ceramic pot filter …
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