Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Distant metastasis"”.
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Prognostic Value of Bone Marrow Micrometastasis Detected by Nnested RT-PCR for Cytokeratin 19 and Mammaglobin in Breast Cancer
… cancers in the early phase frequently undergo distant metastasis, and survival of patients is greatly dependent on distant metastasis. Occurrence of micrometastasis has been suggested to relate with prognostic features of breast cancer, such as lymph node metastasis and the presence of vascular …
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Tp53 As A Biomarker In Head and Neck Squamous Cell Carcinoma
… disease-free survival, and an increased rate of distant metastasis. When examined as an independent factor, disruptive mutation was strongly associated with the development of distant metastasis.</p> <p>As a second aim of this project, we performed a pilot study examining the utility of the …
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The Effect of Dietary Genistein on Breast Cancer Treatment and Metastasis
… genistein was shown to promote breast cancer metastasis to lungs in athymic mice. The results from these studies suggest that the consumption of dietary supplements containing genistein may not be safe to breast cancer survivors. In our third study, we evaluated three metastasis models using …
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Endoscopic Resection and Post-Operative Brachytherapy in the Treatment of Sinonasal Melanoma
… (80%). Three out of five patients developed distant metastasis. Median time to metastasis was 54 months. One patient received immunotherapy after diagnosis of distant metastasis (BRAF positive). Three out of five patients (60%) died from the complications of distant metastases of sinonasal …
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… patients still suffer from a significant risk of distant metastasis (DM). Thus, developing methods to better identify and treat NPC patients at risk of DM is of paramount importance. MicroRNAs (miRNAs) have been shown to provide insight into both the biology and clinical behaviour of human …
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Evaluation of 18F FDG-PET/CT in Patients with Gastric Signet Ring Cell Carcinoma : Correlation with GLUT-1 Expression and Histologic Finding
… wall invasion, depth of invasion, extent of LN metastasis, overall stage and tumor size were also correlated with SUVmax. On the other hand, age, sex and the presence of distant metastasis were not related with SUVmax. Multivariate analysis revealed that the membranous GLUT-1 expression and the …
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Prognostic Factors in Transitional Cell Carcinoma of Upper Urinary Tract after Radical Nephroureterectomy
… patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. On univariate analysis, hydronephrosis, T stage, N stage, and …
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Diffusion Weighted MR Imaging in the Differentiation between Metastatic and Benign Lymph Nodes in Canine Patients with Head and Neck Disease
… regional lymph node involvement or evidence of distant metastasis can have worse prognoses and significantly decreased survival. Lymph node size alone has been shown to be insufficient as a predictor for the accurate clinical staging of some canine neoplasia, including oral malignant melanoma. …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… an independent prognostic marker for predicting distant metastasis and biochemical recurrence and its expression in radical prostatectomy biopsies concurred with diagnostic biopsies (concordance 87.6%). Using the human cell lines, LNCaP (androgen-sensitive) and DU145 (androgen-insensitive), we …
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Aspirin Use Is Associated with Improved Outcomes in Inflammatory Breast Cancer Patients
… of breast cancer and has a high propensity for distant metastases. Our previous data suggested that aspirin (ASA) use may be associated with reduced risk of distant metastases in aggressive BC; however, there are no reported studies on the potential benefit of ASA use in patients with IBC. …
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Sphingosine Kinase 1 Regulates Fascin Expression to Promote Metastasis In Triple Negative Breast Cancer
<p>Distant metastasis is the primary cause of breast cancer–related mortality. To date, effective therapeutic drugs that target metastasis are still lacking. Triple negative breast cancer (TNBC) occurs in high frequency in young women and are more likely to recur and metastasize than are other …
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Synthetic Lethality of Cdk Inhibition and Doxorubicin In Triple-Negative Breast Cancer Requires P53 Inactivation
… patients are at increased risk of developing distant metastasis and have decreased overall survival compared to non-TNBC patients. A majority of TNBC tumors carry p53 mutations, enabling them to bypass the G1 checkpoint and complete the cell cycle even in the presence of DNA damage. Therefore, …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… the role of EPAC1 in promoting invasion and metastasis of pancreatic ductal adenocarcinoma (PDA) and immune regulation, through modulation of the activity of regulatory T-cells (Treg), a subset of T-cells that suppress the immune system and maintain immune tolerance. In three common PDA cell …
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The role of genetic factors in breast cancer aetiology
… receptor status and the presence of distant metastases.<br/><br/>We genotyped 206 SNPs across 30 candidate genes in 1001 patients. Association was performed<br/>using Cochran-Armitage trend test and 2-by-3 tables of disease by genotype.<br/><br/>We replicated observations from …
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The role of tumor-associated macrophages in pancreatic cancer
… desmoplastic stroma, and most patients die of distant metastasis. Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and play essential roles in the regulation of tumor progression and immunity. In recent years, macrophage-targeted monotherapy or …
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Adaptive Spline Method for the Assessment of Cell Motility and its Application to Lesions
… mortality in western Europe. Cancers which form distant metastasis are difficult to contain. Measures to stimulate or inhibit movement of cancer cells may play an important part in metastasis biology. The movement behaviour of individual cells within a cluster may give new clues about …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… a correlation between HIF-2α expression and distant metastasis and impaired prognosis, suggesting that HIF-2α has an important role in tumor progression. We also show differential time and oxygen dependent regulation of the two different HIF-α subunits and differences in their contribution to …
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Roles of the ING1 Epigenetic Regulator in Breast Cancer
… role in breast cancer development and metastasis was unknown, we analyzed ING1 levels in patient samples and correlated it to patient outcome. We also studied the effects of altering ING1 levels in metastasis assays in vitro and mouse metastasis model in vivo. ING1 levels were lower in …
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Sino-Nasal Squamous Cell Carcinoma (SNSCC): a retrospective review of the treatment outcomes of patients treated at Groote Schuur Hospital, Cape Town, South Africa
… disease was seen in 13 (40,63%) patients and distant metastasis in 4 (12,50%) patients. Most patients underwent palliative intent treatment with only 11 (34,38%) having radical treatment. The cumulative 2- and 5-year OS from the date of treatment initiation was 26% and 19% respectively. Median …
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The Role of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma and Its Regulation By Hematopoietic Progenitor Kinase 1
… was associated with higher frequencies of distant metastasis and was an independent prognostic factor for both poor overall and recurrence-free survivals in patients with stage II PDA (p = 0.03 and 0.04). Axl silencing by shRNA in pancreatic cancer cell lines, panc-28 and Panc-1, decreased …
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