Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Distal regulatory elements"”.
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Investigation of transcription factor binding at distal regulatory elements
… is in part orchestrated by a class of remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA looping. Enhancers typically contain clusters of transcription factor binding sites, and TF recruitment to them is thought to play a key role in …
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THE APPLICATION OF HISTONE ANALYSIS FOR IDENTIFYING DISTAL REGULATORY ELEMENTS - REGULATION OF FSHR
… have been used technically to identify numerous distal regulatory elements and furthered our knowledge of transcriptional regulation and cell-specific gene regulation. Fshr is a gene expressed only in testicular Sertoli cells and ovarian granulosa cells and its expression is critical for proper …
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Dynamic regulation and functions of locus-specific DNA methylation
… regulation of DNA methylation at various genetic elements have gathered tremendous interest over decades. The methylomes of many cell types have been described, revealing a dynamic and tissue-specific pattern of DNA methylation (tissue-specific differentially methylated regions, T-DMRs) in the …
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DISCOVERY OF NOVEL EPIGENETIC MECHANISMS OF CARCINOGENESIS BY GENOME-WIDE PROFILING OF NON-CODING REGULATORY ELEMENTS
… are also informative of the activity states of distal regulatory elements. Therefore we can use these epigenetic marks to study important regions of the cancer genome that are key regulators of transcription with unprecedented resolution and accuracy. In this work, in-depth studies of epigenetic …
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
… engineering uncovers the essential role of distal regulatory elements (REs) in the epithelial expression of Cebpa in mouse lungs. Integrated analysis of single-cell multiome as well as bulk cell-type-specific histone ChIP-seq identifies potential REs across major lung cell types. CRISPR …
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Dissecting The Roles of Human Smc Complexes In Transcription Regulation and Chromatin Organization
<p>Metazoans utilize a constellation of distal regulatory elements to control gene transcription, and therefore they have to forge highly complex chromatin loops to spatially bridge these regulatory elements and genes in the three-dimensional (3D) genome. However, the hierarchy of chromatin …