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Showing 1 to 15 of 15 for “"Dissolution tests"”.
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Hydrodynamic effects of a cannula in a USP dissolution testing apparatus 2
Dissolution testing is routinely used in the pharmaceutical industry to provide in vitro drug release information for drug development and quality control purposes. The USP Testing Apparatus 2 is the most common dissolution testing system for solid dosage forms. Usually, sampling cannulas are used …
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Comparative analysis of the dissolution performance of aspirin tablets in the usp apparatus 2 and in a minivessel dissolution system
Dissolution testing is a critical component of quality control procedures in the pharmaceutical industry in order to ensure that the final solid dosage forms have consistent dissolution properties. Dissolution tests are also routinely conducted to evaluate the in-vitro performance of solid dosage …
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The use of ATR-FTIR to probe the release mechanism from hydrophilic matrices.
… principal components analysis (PCA). Standard dissolution tests of the binary and tertiary systems gave an indication about the release behaviour of the formulations in different dissolution media. Total dissolution of the drug was observed in 0.1N HCl for binary mixtures and in both pH 6.8 …
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Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system
Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this …
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QUANTIFICATION OF ASPARTAME IN LOZENGES AND TABLETOP SWEETENERS VIA MULTIPLE PARAMETER MANIPULATION BY USING DISSOLUTION STUDIES WITH UV-VIS, ULTRA-HPLC, AND MATHEMATICAL DRUG MODELING
… such as menthol, when studying the kinetics of dissolution.</p> <p>In this study, aspartame was analyzed in Halls and Ricola lozenges and other tabletop sweeteners such as NJoy, Natra, Equal powder and tablets. The dissolution test is one of the essential assays required to be passed before a …
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Preparação e caracterização de complexos multicomponentes contendo ciclodextrinas e benznidazol
… drug has low solubility, which restricts its dissolution rate. Thus, the present work aimed to study the BNZ interactions in binary systems with beta cyclodextrin (β-CD) and hydroxypropyl-beta cyclodextrin (HP-β-CD), in order to increase the apparent aqueous solubility of drug. The influence …
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Optimizing the structure and plasticization resistance of asymmetric polyimide hollow fiber membranes for CO2 removal from natural gas
… and plasticization phenomenon. Gas sorption tests were performed on the in-house fabricated Matrimid hollow fibers with various ranges of separation properties, and the Henry’s and Langmuir sorption isotherms were decoupled and compared against the pressure. The sorption observations …
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Tailoring electrospun nanofibers and electrosprayed nanoparticles to enhance cellular uptake of low bioavailability drugs
… for PVP/1% (w/w) hemin fibers. Preliminary dissolution tests showed that PVP/ hemin fibres completely dissolved in PBS within 10 minutes. Whereas eudragit/hemin fibres took 2 to 3 days to dissolve. PVP-360 made hemin dissolve successfully in PBS, so further development was focused on …
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Dissolution of disintegrating solid dosage forms in a modified dissolution testing apparatus 2
Dissolution tests are routinely carried out in the pharmaceutical industry to determine the dissolution rate of solid dosage forms. Dissolution testing serves as a surrogate for drug bioavailability through in vitro-in vivo correlation (IVIVR), and it additionally helps in guiding the development …
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Hydrodynamic effects of an arch-shaped fiber optic probe in a dissolution testing apparatus 2
Dissolution testing is widely used in the pharmaceutical industry to evaluate newly developed drug formulations and as a quality control method to insure that solid dosage forms have consistent dissolution property. Typically, samples are manually drawn from the dissolution vessel prior to …
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Hydrodynamics investigation of in-vitro dissolution testing
Dissolution testing is routinely carried out in the pharmaceutical industry to determine dissolution rate of solid dosage forms. The United States Pharmacopoeia (USP) Dissolution Apparatus II is the device most commonly used for this purpose. Despite its widespread use, dissolution testing remains …
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Electrodeless electro hydrodynamic printing of personalized drug dosages
… in lowly volatile polyethylene glycol carrier. Dissolution tests were performed following United States Pharmacopeia (USP) protocol, and the drug release data was analyzed to identify the underlying drug release mechanisms from the assembled unit dosages. Data showed that the DOD method met the …
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Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product
… a tableted drug product, a cornerstone CQA is dissolution.</p> <p>Often, a formulation and/or manufacturing process can change during a patient’s course of treatment, potentially jeopardizing the consistent performance of the drug product. Regulatory agencies typically require that sponsors …
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Hydrodynamics, dissolution, and mass transfer effects in different dissolution testing apparatuses and laboratory systems
Dissolution testing apparatuses and shaker flasks agitated by shaker tables are laboratory systems routinely found in many laboratories at most companies and agencies, and especially in pharmaceutical companies. These devices are commonly used in a number of applications, from drug development to …
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Effects of operating and geometric variables on hydrodynamics and tablet dissolution in standard and modified dissolution testing apparatuses 2
Dissolution testing is routinely conducted in the pharmaceutical industry to provide critical in vitro drug release information for quality control purposes, and especially to assess batch-to-batch consistency of solid oral dosage forms such as tablets. Among the different types of apparatuses …