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Showing 1 to 20 of 24 for “"Dissolution testing"”.
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Hydrodynamics investigation of in-vitro dissolution testing
Dissolution testing is routinely carried out in the pharmaceutical industry to determine dissolution rate of solid dosage forms. The United States Pharmacopoeia (USP) Dissolution Apparatus II is the device most commonly used for this purpose. Despite its widespread use, dissolution testing remains …
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Hydrodynamic effects of a cannula in a USP dissolution testing apparatus 2
Dissolution testing is routinely used in the pharmaceutical industry to provide in vitro drug release information for drug development and quality control purposes. The USP Testing Apparatus 2 is the most common dissolution testing system for solid dosage forms. Usually, sampling cannulas are used …
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Dissolution testing of prednisone and salicylic acid calibrator tablets at different tablet locations
Dissolution testing is routinely carried out in the pharmaceutical industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP …
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Dissolution of disintegrating solid dosage forms in a modified dissolution testing apparatus 2
Dissolution tests are routinely carried out in the pharmaceutical industry to determine the dissolution rate of solid dosage forms. Dissolution testing serves as a surrogate for drug bioavailability through in vitro-in vivo correlation (IVIVR), and it additionally helps in guiding the development …
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Hydrodynamics, dissolution, and mass transfer effects in different dissolution testing apparatuses and laboratory systems
Dissolution testing apparatuses and shaker flasks agitated by shaker tables are laboratory systems routinely found in many laboratories at most companies and agencies, and especially in pharmaceutical companies. These devices are commonly used in a number of applications, from drug development to …
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Hydrodynamic effects of an arch-shaped fiber optic probe in a dissolution testing apparatus 2
Dissolution testing is widely used in the pharmaceutical industry to evaluate newly developed drug formulations and as a quality control method to insure that solid dosage forms have consistent dissolution property. Typically, samples are manually drawn from the dissolution vessel prior to …
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Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system
Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this …
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Effects of operating and geometric variables on hydrodynamics and tablet dissolution in standard and modified dissolution testing apparatuses 2
Dissolution testing is routinely conducted in the pharmaceutical industry to provide critical in vitro drug release information for quality control purposes, and especially to assess batch-to-batch consistency of solid oral dosage forms such as tablets. Among the different types of apparatuses …
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Effect of tablet compression on the dissolution of aspirin tablets using a novel off-center paddle impeller (opi) dissolution testing system
In the pharmaceutical industry, dissolution testing is routinely carried out to determine the dissolution rate of oral solid dosage forms. Among several testing devices, the USP Dissolution Apparatus 2 is the device most commonly used. However, despite its widespread use, this apparatus has been …
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Experimental determination of the agitation requirements for solids suspension in dissolution systems using a mini paddle apparatus
Dissolution testing is a critical step in quality control of manufactured final products in the pharmaceutical industry. The United State Pharmacopeia (USP) Dissolution Testing Apparatus 2 (paddle) is the most widely used dissolution test devices in the pharmaceutical industry to formulate solid …
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METHOD DEVELOPMENT OF STANDARD DILUTION ANALYSIS ON MOLECULES AND DISSOLUTION STUDIES OF IBUPROFEN TABLETS ALONG WITH COMMON BEVERAGE CONSTITUENTS
… of medicinal formulations. One analysis, dissolution testing evaluates the rate at which the medicinal formulation forms a solution to predict <em>in vivo</em> drug release. Dissolution testing on ibuprofen tablets alone and in the presence of ascorbic acid or caffeine was performed to …
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Applications of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) in pharmaceutical analysis
Dissolution testing is one of the most time-consuming, costly, and laborious tasks in the pharmaceutical industry, and yet it is a cornerstone of quality control testing and product release. Dissolution testing is a prerequisite for the quality control and release to market of nearly every …
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Development and characterization of a novel drug dissolution test method using a quartz crystal microbalance
<p>Current dissolution apparatuses require several hundred milligrams of sample per trial, measure dissolution rate indirectly via concentration sampling, and cannot maintain sink conditions throughout the duration of a test. This work describes a novel dissolution testing methodology developed …
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The design and characterisation of multiparticulate lipidic systems for oral drug delivery
… diffraction, scanning electron microscopy and dissolution testing were successfully employed to identify changes to the physicochemical properties of materials that may impact product performance.
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Comparative analysis of the dissolution performance of aspirin tablets in the usp apparatus 2 and in a minivessel dissolution system
Dissolution testing is a critical component of quality control procedures in the pharmaceutical industry in order to ensure that the final solid dosage forms have consistent dissolution properties. Dissolution tests are also routinely conducted to evaluate the in-vitro performance of solid dosage …
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
Poor dissolution in gastrointestinal fluids remains a critical limitation to the oral absorption of many poorly water-soluble drugs. Co-milling offers a solvent-free and industrially scalable technology to overcome dissolution rate limited absorption. However, its broader application has been …
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Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique
… Most of the NCE’s are lipophilic and have dissolution rate issues. Low dissolution rate of the drugs result in poor bioavailability. To overcome poor bioavailability, an adsorption technique is developed to enhance the apparent dissolution rate of poorly-water soluble drugs. In this study, …
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… the flow properties of the granulations. Tablet dissolution testing showed that the large sized HPMC particles were unable to percolate through the tablet and form a consistent network. Roller compaction helped to break down the large HPMC agglomerates and distribute them more evenly within the …
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Pharmaceutical applications and crystal structures of trehalose and its derivatives.
… of the tablet matrix. Accelerated storage testing has been undertaken for ascorbic acid tablets under conditions of elevated humidity and heat, with comparisons made to tablets stored under less deleterious conditions. Molecular and physical mixing techniques of nitrofurantoin and sugar …
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Activation of Release by Hydration in Pharmaceutical Tablets Studied by Terahertz Pulsed Imaging
… for tablet disintegration and subsequent drug dissolution. Even for tablets that do not disintegrate (e.g. sustained release tablets), hydration of the oral solid dosage form still plays a critical role in activating the drug release. In this thesis, terahertz pulsed imaging (TPI) was used to …
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