Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Disrupted-In-Schizophrenia 1"”.
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Investigating putative pathogenic mechanisms within a family in which a chromosomal translocation confers risk of major mental illness
In a large Scottish family a high incidence of schizophrenia, bipolar disorder and major depressive disorder co-segregates with a balanced autosomal translocation (t(1;11)(q42.1;q14.3). The translocation disrupts Disrupted-in-Schizophrenia-1 (DISC1) and DISC2 on chromosome 1, and DISC1FP1 …
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NDE1 in the DISC1 pathway: interactions of schizophrenia-related proteins
The Disrupted-In-Schizophrenia 1 (DISC1) gene is one of the most established risk genes for psychiatric illness currently being studied, having originally been identified as being directly disrupted by a balanced chromosomal translocation that cosegregates with schizophrenia and other major mental …
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Aberrant assembly and function of a hippocampal circuit in a genetic mouse model of schizophrenia
Schizophrenia is highly heritable yet very few genetic risk variants have been unequivocally linked to the disease. Disrupted in Schizophrenia 1 (DISC1), was first discovered in a family with a balanced translocation t (1; 11) (q42; q14) and a history of psychiatric disease that segregates with the …