Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Displacement amplification"”.
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Large gain amplification mechanism for piezoelectric actuators utilizing a rolling contact joint
Due to the limited displacement of piezoelectric stack actuators, common practice is to use some form of displacement amplification mechanism. An efficient, heavy-duty displacement amplification mechanism for piezoelectric stack actuators is presented in this thesis. The displacement amplification …
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Large-strain piezoelectric actuators using controlled structural buckling
… a useful mechanism for gaining extremely large displacement amplification, since a infinitesimal displacement in the axial direction of the beam may lead to a large deflection in the middle of the beam. This thesis presents a novel large-strain piezoelectric actuator exploiting the buckling of a …
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Influence of intense ground motion on p-delta effect amplification
… Angeles region and the overturning moment and displacements are recorded. The responses are highly dependent on the ground motions, and there is some amplification due to the second-order analysis. The 20-story benchmark structure had more of a second-order amplification, but the moment …
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CRISPR-integrated Biosensors for Human Health: Novel strategies for pathogen detection and cancer screening
… a CRISPR/Cas14a system combined with blocker displacement amplification enabled sensitive detection of the BRAF V600E mutation in colorectal cancer cells. Fourth, a one-pot CRISPR/Cas13 biosensor was designed for simultaneous detection of E. coli O157:H7 serotype markers, validated in a mouse …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
… and the need for high sequencing depth. Blocker Displacement Amplification (BDA) technology enables selective detection of such rare alterations with NGS. Here, we demonstrate the effective detection of <em>KMT2Ar </em>and its various FPG with a novel NGS assay leveraging BDA. Primers were …
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Piezoelectric buckling actuators : form reduction, bidirectional control, and optimal switching
… high bandwidth response, and limited yet precise displacement properties. As a result, these actuators have been widely applied to precision positioning devices, acoustical and optical instruments, and within vibration control mechanisms. Techniques to efficiently amplify this limited displacement …
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Performance Modeling and Efficiency Analysis for a Piezohydraulic Pump with Active Valves
… to tiny strain of the piezoelectric materials, displacement amplification mechanism should be incorporated into design for most commercial applications. Piezohydraulic actuation provides an ideal amplification that can achieve any combination of stroke and force, which is superior than most …
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Harmonic poly-actuator : design and control of a new piezoelectric mechanism
… order of 0.1%. For marco-scale applications, the displacement must be amplified, typically through mechanical or frequency leveraging. Both have inherent limitations: mechanical devices can increase the stroke but is naturally limited; and frequency devices relies on friction and is limited to …
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Developing and Optimizing Conditions for Single Cell Genetic Analysis
… A recent multi-center study determined a 17% amplification failure rate overall and a 3.4% misdiagnosis rate (ESHRE PGD consortium steering committee, 2002). Experiments presented here were conducted to decrease those rates by optimizing single cell sensitivity and specificity of PGD …
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Diversity of Skin Infections
… microorganisms, using a combination of multiple displacement amplification (MDA), which amplifies all DNA in a sample without any requirement of prior knowledge of the nucleotide sequence, degenerate “general HPV primers” PCR and high-throughput sequencing. The most common microbial DNA in NMSC …
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Investigating Metastatic Lineage In Colorectal Cancer By Single Cell Dna Sequencing
… combines flow-sorting of single nuclei, multiple-displacement-amplification using Φ29 polymerase, low-input library preparation, library barcoding, targeted capture and NGS to generate high-coverage data from single cells. We validate this method by generating high coverage sequencing data from …
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Extracellular Vesicle Capture and microRNA Detection
… present within them. First, we develop various amplification strategies in hydrogel particles for microRNA detection, including a colorimetric detection platform that can be translated to point-of-care settings for a liquid biopsy. We also explored other amplification strategies for increased …
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A piezoelectric translational flow agitator for active air cooling of electronics.
… agitator generates high frequency and large displacement motion to a blade. It is driven by an oval loop shell that amplifies the small displacement of the piezo stack actuator to the several-millimeter range. Detailed vibration characteristics were studied through theoretical and …
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Elucidating aquatic virioplankton diversity and dynamics using high-throughput DNA sequencing
… preparation strategies employ some form of amplification to obtain sufficient DNA for sequencing. Biases resulting from these techniques may alter interpretations of the occurrence and abundance of viral populations from metagenome data. In turn, these biases may lead to misinterpretations …