Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Dishevelled"”.
-
Regulation of Wnt signalling pathways by the Dishevelled DEP domain
… All Wnt signals are relayed by the hub protein Dishevelled (DVL). During canonical (β-catenin dependent) signalling, Dishevelled assembles signalosomes via dynamic head-to-tail polymerization of its DIX domain, which are cross-linked by its DEP domain through a conformational switch from monomer …
-
Structural Basis for Dishevelled-2 Association to the Plasma Membrane
… The DEP domain, located on the C-terminus of Dishevelled (Dvl), plays a role in cytoplasm-membrane association, which branches the canonical and non-canonical Wnt signaling pathway within the cell. It has been suggested that the DEP domain requires the recruitment of ionic lipids, such as …
-
Characterisation of the Rho GTPase target Dishevelled Associated Activator of Morphogenesis 1 (DAAM1)
Dishevelled Associated Activator of Morphogenesis 1 (DAAM1) is a formin which is important for gastrulation. In this thesis, we have sought to characterise DAAM1 in terms of its regulation and function. DAAM1 was found to localise to the perinuclear/Golgi region as well as to the actin/myosin II …
-
Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
… embryogenesis. The Formin-homology protein Dishevelled associated activator of morphogenesis 1 (Daam1) was previously characterized as an essential component for non-canonical Wnt-dependent regulation of cytoskeletal reorganization and cell migration. Daam1 and Daam2 are members of the Daam …
-
Dact Family Molecules In Wnt Signaling In Mouse Development
… pathways converge on the intracellular protein Dishevelled, whose interactions appear essential in determining the cell-autonomous effects of the Wnt signal. Dact: Dapper, Antagonist of Beta Catenin Targeting) proteins were identified based on their binding to Dishevelled. There are three Dact …
-
Casein Kinase I Transduces WNT Signals
… experiments indicated that CKI acts between Dishevelled and GSK-3. Yeast twohybrid assays showed that CKI strongly binds Dishevelled. Through in vivo phosphorylation experiments, we showed that CKI increases Disheveled phosphorylation and in vitro experiments showed that CKI can directly …
-
Mechanisms of molecular switching in the Wnt signal transduction pathway
… of Wnt; the ‘signalosome’, which is assembled by Dishevelled upon Wnt-receptor binding to inactivate the degradasome, thus allowing β-catenin to accumulate; and the ‘enhanceosome’, which captures β-catenin, granting it access to target genes and relieving their transcriptional repression by …
-
The Role of Daam1 In Kidney Development
… the role of the Wnt/Planar Cell Polarity formin, Dishevelled-associated activator of morphogenesis 1 (Daam1), in shaping nephric tubules. We show that Daam1 governs nephron morphology by regulating E-cadherin-based cell-cell adhesion of progenitor cells and junctional actin filaments' stability. …
-
The Role of Daam1 In Kidney Development
… the role of the Wnt/Planar Cell Polarity formin, Dishevelled-associated activator of morphogenesis 1 (Daam1), in shaping nephric tubules. We show that Daam1 governs nephron morphology by regulating E-cadherin-based cell-cell adhesion of progenitor cells and junctional actin filaments' stability. …
-
Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… of the wingless signaling pathway, porcupine, dishevelled, and armadillo also positively regulate NB formation and specification. On the other hand, zeste-white 3 acts oppositely in both processes. It was further demonstrated that the wingless signaling pathway activates the expression of the …
-
The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
… of the wingless signaling pathway, porcupine, dishevelled, and armadillo also positively regulate NB formation and specification. On the other hand, zeste-white 3 acts oppositely in both processes. It was further demonstrated that the wingless signaling pathway activates the expression of the …
-
The Role of NADPH Oxidase in ROS Mediated Differentiation
… preventing its ability to bind and inhibit Dishevelled. This in turn positively impacts on the WNT/β- catenin signaling pathway leading to differentiation. The source of endogenous ROS seen following RA treatment was investigated and members of the NADPH oxidase (NOX) family were identified …
-
Daple Orients and Patterns Sensory Hair Bundles in the Inner Ear
… Gαi3. One of the most promising candidates, Dishevelled-associating protein with a high frequency of leucine residues (Daple), interacts with core PCP and cell-intrinsic signals. Here I show that Daple participates in the implementation of cell-intrinsic polarity. Regulated by G-protein …
-
Local Wnt11 Signalling and its role in coordinating cell behaviour in zebrafish embryos
… recruits the intra-cellular signalling mediator Dishevelled (Dsh) to those sites. Monitoring these apparent Wnt11 signalling centres through time-lapse confocal microscopy revealed, that Wnt11 activity locally increases the persistency of cell-cell contacts. In addition, I found that the atypical …
-
Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… protein 15 (ADAM15), Segment polarity protein dishevelled homolog DVL3 (DVL3) and Optineurin (OPTN) were identified as TRIF-interacting partners. Their interactions with TRIF were also confirmed by direct immunoprecipitation experiments of overexpressed and endogenous TRIF. More specifically, …