Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Disease-modifying Antirheumatic Drugs"”.
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Approvals, Utilization, and Cost of Biologics for the Treatment of Rheumatoid Arthritis
… by the development and approval of biologic disease-modifying antirheumatic drugs (bDMARDs). However, the approval status, utilization, and high cost of bDMARDs pose challenges in RA management.</p> <p><strong>Objectives:</strong> This dissertation evaluated the association between the …
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Comparative Effectiveness of Methotrexate-Based Disease-Modifying Antirheumatic Drug Combinations for Rheumatoid Arthritis
… with adding a conventional synthetic (cs) disease-modifying antirheumatic drug (DMARD), tumor necrosis factor inhibitor (TNFi) biological (b) DMARD, non-TNFi bDMARD, or targeted synthetic (ts) DMARD for patients with rheumatoid arthritis (RA) initiating methotrexate (MTX); [2] to compare …
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Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability.
… baseline characteristics such as diagnosis, disease duration, previous and ongoing disease modifying antirheumatic drugs (DMARDs), treatment start and termination. In addition efficacy measures used for calculating treatment response, i.e. EULAR and ACR response criteria, were collected at …
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Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects
… agents targeting specific mediators of the disease process have been introduced. Tumour necrosis factor (TNF) antagonists have been shown to reduce signs and symptoms of disease and to retard the development of tissue damage in the majority of patients. This thesis focuses on clinical, …
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Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes
Musculoskeletal diseases such as Osteoarthritis (OA) affects over 8.75 million people aged 45 and over in the UK alone, resulting in pain, joint stiffness and lack of mobility of the affected joint. The pathology of OA is mediated by a complex inflammatory response predominantly driven by elevated …
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Changes in peripheral B cell subsets under immunosuppressive therapy
… which may progress to chronic autoimmune diseases. B cells play an important role in the pathogenesis of autoimmune diseases and influence autoimmunity through multiple pathways. With the availability of informative B cell surface markers it is now possible to identify within the …