Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 161 for “"Disease pathogenesis"”.
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH is characterized by steatosis, inflammation, cell death, and liver fibrosis and significantly increases the risk of …
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Understanding Huntington's Disease pathogenesis using next generation sequencing analyses
Huntington's disease is one of nine expanded (CAG) repeat disorders. The expansion in Huntington's disease lies in the first exon of the huntingtin (HTT) gene and is pathogenic when (CAG)>/= 40 . Individuals with Huntington's disease develop motor, cognitive, and psychiatric symptoms in adulthood. …
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THE ROLE OF TRANSLATION ELONGATION DEFICITS IN ALZHEIMER’S DISEASE PATHOGENESIS
Alzheimer’s disease (AD), the most common form of dementia in the elderly, is poised to become a global threat to public health. With a dearth of disease-modifying treatments, it is crucial that we identify novel therapeutic targets based on mechanistic studies of the underlying molecular pathways …
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Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
Alzheimer's disease (AD) is a chronic neurodegenerative condition and the leading cause of dementia globally, affecting around 50 million people. It is characterized by progressive memory and cognitive decline, and pathologically defined by extracellular β-amyloid (Aβ) plaques and intracellular …
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Primary biliary cholangitis: genetic risk, phenotypic stratification and disease pathogenesis
Primary biliary cholangitis (PBC) is a rare disease which occurs in fewer than 1 in 2,000 people, mainly women over the age of 40. It is an autoimmune condition and is phenotypically associated with other immune-mediated inflammatory disorders (IMIDs). It is characterised by progressive destruction …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… their roles still have to be identified in the pathogenesis of different diseases. MicroRNAs (miRNAs) are small (18-25 nucleotide long) non-coding RNAs which play pivotal roles in the gene expression process and it is estimated that about one third of the human genome is controlled by miRNAs. …
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Monocyte Modulation of Disease Pathogenesis and Progression in Localized Aggressive Periodontitis
… phenotype of the myeloid cell contributes to disease pathogenesis and progression through mechanisms mediating host inflammatory and immune responses. LAgP monocytes synthesize increased levels of the potent proinflammatory lipid mediator, Prostaglandin E2 (PGE2), preferentially differentiate …
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Substrate Selection by the 20S Proteasome and Implications in Disease Pathogenesis
… of the brain in patients with Parkinson’s disease, diffuse Lewy body disease, and the Lewy body variant of Alzheimer’s disease. Within Lewy bodies, several modifications of alpha-synuclein have been identified, including truncations from either terminus. Several observations support a role …
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Interferon-Dependent Mechanisms of Disease Pathogenesis in Respiratory Syncytial Virus Infection
… as important contributing factors, the pathogenesis of RSV bronchiolitis and the cellular/molecular mechanisms that determine its clinical severity remain incompletely understood. A hallmark of RSV is its resistance to the canonical antiviral activity of interferon type I (IFN I) and at …
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Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
The innate immune response plays a crucial role in recognising and combating viral infections. Double-stranded RNA (dsRNA) is a potent proinflammatory signal, and its recognition by MDA5 and its coregulatory factor, LGP2, is essential for initiating antiviral responses. This study aimed to …
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Elucidating the role of peptidoglycan from Borrelia burgdorferi in Lyme disease pathogenesis
… — a debilitating late-stage symptom of Lyme disease. Symptoms remain even after the completion of antibiotic therapy and when there is no longer any indication of an active infection. Studies have found that a portion of the bacterial cell wall from the causative agent, Borrelia burgdorferi, …
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From skin development to disease pathogenesis and therapeutics. ‘The power of 3D skin models’.
Contains fulltext : MMUBN000001_886519195.pdf (Publisher’s version ) (Open Access)
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Modeling Diamond-Blackfan Anemia in the Mouse: Disease Pathogenesis and Evaluation of Novel Therapies
… ribosomal protein S19 (RPS19) is the most common disease gene (25% of the cases). All reported patients are heterozygous for the mutations and in most cases the mutations are predicted to result in haploinsufficiency of the respective ribosomal protein. Knowledge about DBA pathophysiology has been …
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Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
Inflammatory bowel disease (IBD) is an abnormal immune response to the gut microbiome causing chronic debilitating pain in genetically susceptible people. The development of effective therapies for this condition is hampered by a poor understanding of its complex aetiology. Progress in this area will …
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Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila
<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the <em>S</em><em>ubstantia nigra</em><em> pars compacta</em> region of the brain. PD is also the most common neurodegenerative disorder and the second most common …
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Vascular Disease Pathogenesis In Smooth Muscle Dysfunction Syndrome and Majewski Osteodysplastic Primordial Dwarfism Type Ii
<p>Vascular diseases are a leading cause of morbidity and mortality world-wide. Understanding their pathogenesis is crucial to better diagnosis and management of these life-threatening conditions. Through the study of rare mutations that lead to early onset and severe vascular diseases, we can …
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Rheumatoid Arthritis: Elucidation of genetic factors and the role of dendritic cells in the disease pathogenesis
Contains fulltext : 141339.pdf (Publisher’s version ) (Open Access)
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Disease pathogenesis, treatment effectiveness, and co-morbid burden among adult patients with primary immune thrombocytopenia (ITP)
… immune thrombocytopenia (ITP) is an autoimmune disease involving autoantibody-mediated platelet destruction, suboptimal platelet production, and T-cell-mediated platelet lysis. These processes cause a decreased peripheral blood platelet count (< 150 x 109/L), resulting in an increased …
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New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
Alzheimer’s disease (AD) is the most common form of age-related dementia. Our current understanding of AD pathogenesis is largely based on data from cases of relatively rare early-onset forms of the disease, collectively known as familial AD (FAD). FAD is associated with discrete mutations in three …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… role of the innate γδ T-cell population in MS pathogenesis. In particular, some γδ T-cells that express Fc receptors (FcR), such as CD16, that bind antibody are more prominent with MS disease progression and have been shown to exert cytolysis via antibody-dependent cellular cytotoxicity (ADCC). …
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