Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 144 for “"Disease models"”.
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hiPSC-Derived Cerebral Small Vessel Disease Models
Cerebral small vessel disease (cSVD) is an umbrella term of disorders that affect the small perforating arteries of the brain and is a major cause of stroke and dementia worldwide, but its pathology is yet to be known. We hypothesise that the integrity of the blood brain barrier (BBB) is disrupted …
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Targeting DNA Repair in Prostate Cancer: Therapeutic Combinations & Disease Models
… genetic alterations in men with poor prognosis disease, as well as clinical reports of PARP inhibitor efficacy in patients with and without defective homologous recombination repair defects, when combined with standard-of-care antiandrogen therapies. However, the dominant molecular mechanisms …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… patients have identifiable syndromic genetic diseases, yet a number of genetic non-syndromic patients have been identified. Infusion of angiotensin II into mouse models causes aortic disease through inflammation and fibrosis. An angiotensin type I receptor (AT1R) blocker (ARB) or an …
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Meta-Analysis of Rodent Behavior in Various Brain Injury and Disease Models
… neurocognitive profiles specific to rodent models of cortical and subcortical brain injury that grossly resemble deficits observed in human brain injury. This study also used exploratory factor analysis to examine the latent factor structure present in behavioral assay data. The factor …
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The use of MALDI-MS for imaging drug disposition in respiratory disease models.
Matrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) has been extensively applied to monitoring the distribution of pharmaceutical compounds in tissues. The main aim of the work reported in this thesis is to monitor the distribution of respiratory compounds in the lungs …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
Alzheimer’s disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) peptides and amyloid plaque deposition. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily …
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A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… a microfluidic approach to model cardiovascular diseases and evaluate therapeutic candidates. In our studies, we recreated sterile occlusive thrombosis under a wide range of pressure drops and investigated the effect of hemodynamic forces on neutrophil activities during clot formation. We …
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Optical imaging methods for the study of disease models from the nano to the mesoscale
The visualisation of disease phenotypes allows scientists to study fundamental mechanisms of disease. Optical imaging methods are useful not only to observe anatomical features of biological samples, but also to infer interactions between molecular species using fluorescence labelling. This thesis …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… on cellular and inflammatory mechanisms in two models of injury and disease. Rodent models of blast induced neurotrauma (BINT) and severe osteoporosis were used to inform the development of 2D and 3D in-vitro models of macrophage/endothelial cell injury and osteogenic differentiation …
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Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway
… with cancer, inflammatory, and autoimmune diseases. Therefore, it is important to identify species in the NF-[kappa]B pathway that if inhibited/ targeted by added drugs normalize the levels of NF-[kappa]Bn. Also, since there is a limit to how effective single drug targets are in complicated …
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Improved Strategies for Controlling Sclerotinia blight of Peanut: Site-specific Disease Models and Advisory, Fungicide Timing, and Pathogen Detection.
… of Sclerotinia blight. Changes in incremental disease incidence were described with 5-day moving averages of modeled site-specific weather variables. The model explained approximately 50% of the variability in Sclerotinia blight index in eight environments from 2002 to 2005. Linear regression …
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OPTIMIZATION OF AAV9 GENE THERAPY FOR SPINAL MUSCULAR ATROPHY WITH RESPIRATORY DISTRESS TYPE 1 USING IN VIVO DISEASE MODELS
… is a rare autosomal recessive motoneuron disease with infantile onset, with an estimated incidence of 1/100’000. It is caused by mutations in the immunoglobulin mu-binding protein 2 (IGHMBP2) gene, which lead to a deficient amount of the encoded protein. The main clinical symptoms are …
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Synthesis and structure-activity relationship studies of novel anti-infectives for cross screening in tuberculosis and malaria disease models
Some 12-16 hours after the invasion of the human erythrocyte by the malaria parasite Plasmodium falciparum, there appear in the erythrocyte membrane ‘new permeability pathways’ which mediate an increased permeability of the infected cell to a range of low molecular weight solutes, including anions, …
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Disordered Protein Aggregates Are Linked to Changes in the Histone Post-Translational Modification Landscape in Disease and Non-Disease Models
… cases being associated with neurodegenerative diseases, eventually leading to death of the organism. In yeast however, the aggregated prion state is associated with positive cellular outcomes, and cells can switch between the [PRION+] and [prion-] states. Understanding the factors that lead to …
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Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group
… resistance to anti-malarial drugs where the disease is endemic. There is therefore a need for continuous research into the application of new techniques as well as the design of new small molecule chemical entities as probes or chemotherapeutic agents.
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Derivation of lymphocytes from human induced pluripotent stem cells
… for treatment of patient specific hematological diseases. This research aims to derive human lymphocytes from hiPSCs. There are three projects: The overall generation of human lymphocytes (B cell, T cell and NK cell) from hiPSCs is explored in Project I. In Project II and III, based on the …
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Longitudinal Visualization of Neurodegeneration: Digital Biopsy of the Retina
As treatment for most retinal diseases only begins after vision impairing degeneration is detectable, a better understanding of what changes lead to neurodegeneration is required. Due to the isolated physiology of the eye, the classical markers of inflammation are not detectable in-vivo without an …
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Modeling 3D Retinogenesis in Mouse Embryonic Stem Cells Following CRISPR-mediated Crx Knockdown
… great potential in terms of patient-specific disease modeling. Although various diseases have been well-studied in animal models, there are limitations with regards to patient-specificity. The generation of animal models to study each specific mutation would be impractical and costly. With …
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Understanding the molecular bases of neurodegeneration: From the structural characterisation of the aggregates to the establishment of an iPSC-derived neuronal model
Neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are associated with the process of protein misfolding and aggregation. The molecular mechanisms by which this process causes the progressive loss of neurons characteristic of these conditions, however, are …
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Modelling and investigating treatments of childhood inherited mitochondrial diseases in zebrafish.
… there is currently a lack of suitable *in vivo* models that allow for disease characterisation and studying treatment. In this thesis I aimed to develop new zebrafish disease models to try and recapitulate features of MDDS to then trial a therapy, nucleoside supplementation, which has been shown …
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