Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 96 for “"Disease model"”.
-
PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… is a quintessential feature of Alzheimer’s disease (AD) and AD mouse models. We and others have previously reported the peroxisome-proliferator activated receptor gamma (PPARγ) agonist rosiglitazone improves hippocampus-dependent cognitive deficits in some AD patients and ameliorates …
-
Axonal transport and life cycle of mitochondria in Parkinson's disease model
… ligase associated with familial Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear how Parkin plays a role in mitochondrial turnover in vivo, and whether the mature neurons possess a compartmentalized Parkin-dependent mitochondrial life …
-
The Impact of Insulin signalling on a C. elegans Alzheimer’s Disease Model
Alzheimer's Disease (AD) represents a significant challenge in aging societies. Researchers found a strong correlation with diabetic patients more likely to develop AD. This study explores the interaction between AD and insulin signalling by employing a transgenic Caenorhabditis elegans model …
-
Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
… malignant hyperthermia (MH). Recently, a mouse model of human MH (Y522S-RyR1) has been developed. In skeletal muscle, Y522S-RyR1 exhibits an increased sensitivity to activation resulting in Ca2+ leak, mitochondrial disorganization, and cellular stress. Although RyR1 expression is limited in the …
-
Genomic Analysis of Human Spinal Deformity and Characterization of a Zebrafish Disease Model
… hindered by the lack of a relevant animal model. Therefore, we used multiple approaches to better understand the genetic and molecular etiology of AIS using human and animal-based studies.</p><p>First, we performed copy number variation analysis on 143 patients with isolated scoliosis using …
-
Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… and aortic complications in a MFS mouse model (Habashi et al. 2006). However, results in clinical trials have been disappointing (Lacro et al. 2014) and it is increasingly apparent that there is a need to develop better disease models for MFS to improve therapy development. In addition to …
-
Nonsmooth Bifurcations and the Role of Density Dependence in a Chaotic Infectious Disease Model
… dimensions (and co-dimensions) than that of ODE models. Classically, the minimal dimension to observe chaotic behavior in an ODE model is three; whereas it can be achieved in a one-dimensional discrete map. It is often the choice of mathematical biologists to use discrete systems as it fills many …
-
Ipsc Based Gene Correction and Disease Model of A New Class of Lgmd Due to Poglut1 Mutation
… <p>To test this, we have used iPSCs for disease modeling and rescue experiments. Using a CRISPR based gene targeting method, we aimed to correct the point mutation and restore POGLUT1 function, thus restoring Notch signaling activity. Following correction, iPSC-derived gene corrected …
-
Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia
… with degenerative myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in DM and control dogs. Samples …
-
Revealing the Mechanism Underlying the Beneficial Effects of Angiotensin-Converting Enzyme Inhibitors in a Drosophila Alzheimer’s Disease Model
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, accounting for most dementia cases worldwide. Current therapies for AD have limited effectiveness in slowing disease progression or delivering a cure. As such, there is an immediate need for ongoing research and innovative …
-
Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative diseases. However, more recent work has begun to suggest that the …
-
The effects of superoxide dismutase on osteoarticular cells and structural analysis of ochronosis, in a disease model of alkaptonuria
… to observe the effects of SOD in an in vitro model of ochronosis, and identify structural changes in this model via Raman spectroscopy. Methods: Immortalised human chondrocytes (C20) and osteosarcoma (MG63) cell lines were cultured in DMEM containing HGA, SOD or a combination of both for up to …
-
Adapting the Standard SIR Disease Model in Order to Track and Predict the Spreading of the EBOLA Virus Using Twitter Data
… method has been developed to track infectious diseases by using data mining of active Twitter accounts and its efficacy was demonstrated during the West African Ebola outbreak of 2014. Using a meme based n-gram semantic usage model to search the Twitter database for indications of illness, …
-
Genetic Reduction of Cholesterol Synthesis in the Mouse Brain Does Not Affect Amyloid Formation in an Alzheimer’s Disease Model, but Does Extend Lifespan
… peptides characteristic of Alzheimer’s disease (AD). To determine whether a decrease in cholesterol synthesis would affect APP processing in vivo, we crossed cholesterol 24-hydroxylase knockout (KO) mice, which exhibit a 50 percent reduction in sterol synthesis, with transgenic mice …
-
The effects of magnesium administration on cardiac ventricular function, heart rate variability, and myocardial morphological changes in a chronic diabetes disease model in rats
… complications include coronary heart disease, cardiac autonomic neuropathy and ventricular dysfunction. Furthermore, DM is associated with electrolyte disturbances such as those involving potassium, calcium and magnesium (Mg2+). Among these electrolyte disturbances hypomagnesemia is …
-
Modelling pandemic influenza progression using Spatiotemporal Epidemiological Modeller (STEM)
… of this project is to incorporate a Poisson disease model into the Spatiotemporal Epidemiological Modeler (STEM) and visualize the disease spread on Google Earth. It is done through developing a Poisson disease model plug-in using the Eclipse Modeling Framework (EMF), a modeling framework and …
-
Sensitivity Analysis and Forecasting in Network Epidemiology Models
… several methods have been proposed for real-time modeling and forecasting of the epidemic curve. These methods range from simple compartmental models to complex agent-based models. In this dissertation, we present a model-based reasoning approach to forecasting the epidemic curve and estimating …
-
Large Scale Disease Modeling
<p>In this we study large scale disease modeling. After understanding the mechanics behind the SIR disease model in an ODE sense, we will apply this knowledge to model disease spread in more and more increasing advanced cellular automata. Eventually, some of our cellular automata will include long …
-
The Identification and Development of Small Molecule Inhibitors of Amyloid β Aggregation
… is a seminal neuropathic agent in Alzheimer’s disease (AD), a multifaceted neurodegenerative disorder for which no preventative measures or disease modifying therapies currently exist. Aggregation of this peptide plays a key role in the synaptic dysfunction and neuronal death associated with …
Page 1 of 5