Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Disease identification"”.
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The Molecular Anatomy of Mitochondrial Disease: Identification and Characterisation of Novel Nuclear-Encoded Mitochondrial Disease Genes
Mitochondrial diseases are a group of clinically and genetically heterogeneous disorders typically associated with abnormal oxidative phosphorylation (OXPHOS). In recent years, next generation sequencing technologies have allowed for accurate genetic diagnoses of inherited mitochondrial diseases …
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Mechanistic studies of beta protein amyloid formation in Alzheimer's disease : identification and characterization of protofibril intermediates
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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Evaluating oxalate-degrading Lactobacillus spp. for their ability to be used as probiotics in the treatment of kidney stone disease
… have suggested it is probably a multifactorial disease. Lactobacillus strains which potentially had increased ability to degrade oxalate were previously isolated from a healthy low kidney stone risk group. The aim of this study was to identify these natural Lactobacillus strains and evaluate …
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Theory and Applications of Matrix Completion in Genomics Datasets
… the door to improvements in drug discovery, disease identification, and personalized medicine, among others. The size and scope of such datasets is unprecedented, and their increased availability over the past decade, in conjunction with rapid advancements in statistical inference and machine …
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Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… (DLBCL) is an aggressive and heterogeneous disease. Identification of prognostic and predictive markers is important to design individualised and effective treatment strategies. This thesis describes different approaches to search for molecular prognostic markers and an attempt to overcome …
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Moving Toward Intelligence: A Hybrid Neural Computing Architecture for Machine Intelligence Applications
… symbol detection, (v) radio fingerprint identification, and (vi) clinical disease identification.
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Enhancers and super-enhancers in human disease and therapy
… in a variety of cell types in both healthy and diseased tissue. It is becoming increasingly apparent that mis-regulation of enhancer regions is a major component of many human diseases, including cancer. In addition, the availability of new classes of small molecule inhibitors targeting …
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Novel customisable phases for micro solid-phase extraction and automated biological sample preparation
… biological processes. They aid in accelerated disease identification, diagnosis, prognosis, and response to treatments. Recently, mass spectrometry (MS) assays have been introduced as an alternate to the conventionally used immunoassays. MS provides accurate and precise quantification due to …
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Automated Wheat Stem Rust Detection using Computer Vision
… the protection of the yield of such crops from diseases is of immense importance. Stem rust is a fungal disease that attacks cereal crops. In particular, it is a common disease that occurs in wheat and destroys 50 to 70% of the yield if left unchecked. The loss of yield would in turn affect the …
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Transcriptomic signatures of recurrent tuberculosis disease and treatment response in HIV-infected individuals
… at particularly high risk of tuberculosis (TB) disease, especially in TB endemic countries where M. tuberculosis transmission is common. Although antiretroviral therapy (ART) reduces risk of TB, it does not return to that of HIV-uninfected persons. In addition, a previous history of TB disease …
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Virtual reality navigation assessment and 7 tesla MR imaging of the entorhinal-hippocampal circuit in asymptomatic at-risk Alzheimer's disease
Identification of the initial alterations of brain function in Alzheimer’s disease (AD) is critically important for early disease detection and future use of disease-modifying drugs to delay progression to dementia. Given that AD-related neurodegeneration is first observed in the entorhinal cortex …