Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Disease free survival"”.
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Pre-operative determination of Carcinoembryonic Antigen (p-CEA) as an independent prognostic factor of Disease Free Survival (DFS) in patients treated for colorectal carcinoma
… fattore di rischio indipendente in relazione al disease free survival. BACKGROUND: Il p-CEA sembra essere correlato sia alla stadiazione della neoplasia colorettale, sia alla prognosi del paziente, sebbene ciò non sia ancora stato certamente dimostrato e sia argomento di un acceso dibattito …
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The incidence, management and outcomes of stage IIIB cervical cancer in a low- and middle-income setting
… is a frequent complication in advanced disease and is associated with poorer outcomes. This review aims to evaluate the management and outcomes of patients with stage IIIB cervical cancer. Aim: To describe the incidence, treatment offered and outcomes in women with stage IIIB cervical …
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Body mass index and response to neoadjuvant chemotherapy in Korean breast cancer
… between pathological complete remission, survival and BMI. MATERIALS AND METHODS: This study is a retrospective study through chart review who received NAC at the Ajou University Hospital from 2001 to 2013. Total 217 patients were enrolled, of which 170 patients who performed MRI scan …
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Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study
… Patient characteristics, tumour characteristics, disease stage, treatment, and follow-up were recorded. Primary objectives included evaluating overall and disease free survival, and analysing recurrence patterns and clinicopathological features. Results: The five-year overall and disease free …
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Pretreatment Serum CYFRA 21-1 Level Correlates Significantly with Survival of Cervical Cancer Patients: A Multivariate Analysis of 506 Cases
… > 4cm was an independent prognostic factor for disease-free survival (OR, 3.110; [95% CI, 1.588-6.093], P=0.001) and overall survival (OR, 8.497; [95% CI, 1.797-40.184], P=0.007) in patients with squamous cell carcinoma, while pretreatment CYFRA 21-1(P=0.010) serum levels had a significant …
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Analysis of factors influencing early outcome following liver resection
… factors associated with tumour recurrence and survival. Methods A retrospective review of a prospectively maintained database of patients undergoing liver resection between 2005 and 2012 was performed. Results and Conclusions Over a seven-year period 504 liver resections were performed. Liver …
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An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors
… clinically correlated with patient outcomes and disease-free survival. There's currently no consensus on mechanistic connection between the two phenomena. The current data on critical signaling pathways as well as the effect of the tumor stroma and cytotoxic therapy is examined. The current body …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
Survival rates from pancreatic cancer have remained stagnant for decades due to the heterogenic nature of the disease. This dissertation aimed to find a new advanced biomarker and evaluate its clinical capabilities, thus enabling more individualised pancreatic cancer management. Between 2013 and …
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Adjuvant Chemoradiation Therapy in Gallbladder Cancer
… The clinicopathologic factors, recurrence and survival were retrospectively analyzed. Patients with gallbladder cancer at T2N0M0, T2N1M0, T3N0M0 and T3N1M0 stages were enrolled in this study. Among the 4 stages, the 2 lymph node-negative stages (T2N0M0 and T3N0M0) did not show any gain in …
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The development of a flow cytometric method to detect the presence of mutated nucleophosmin in Acute Myeloid Leukaemia
… is associated with significantly better overall survival and disease free survival in AML and has been entered as a provisional category in the World Health Organisation (2008) classification of Acute Myeloid Leukaemia with recurrent genetic abnormalities. Current methodology uses reverse …
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ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… promoter methylation negatively correlated with disease-free survival of prostate cancer patients. We also found that the COX2 inhibitor, NS398, downregulated DNMTs and increased the expression of SPARC leading to tumor growth suppression in the bone in vivo. These findings suggest that SPARC …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… is a favorable prognostic marker for distant-disease-free survival. (4) GPR30 confer some constitutive pro-apoptotic signaling but also readily sensitizes the cells to other apoptotic stimuli. (5) GPR30 directly associates with RAMP3 in-vivo and in-vitro and RAMP3 expression has an impact on …
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A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population
… from 1990-2012 in terms of local control (LRC), disease free survival (DFS) and overall survival (OS) and to determine the value of suggested predictive factors in this population. Patients and methods: Retrospective review of all patients diagnosed and treated with osteosarcoma at Groote Schuur …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
… aim of the study was to determine overall survival (OS) of patients with EBV associated NPC treated over an 11-year period. Setting: Groote Schuur Hospital, between January 2003 and December 2013. Methods: This is a retrospective observational study. Medical records of all patients with …
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Prognostic biomarkers for head and neck squamous carcinoma
… for targeted and effective therapeutics for this disease. TRAIL and Smac mimetics are novel promising anticancer agents. However, their effect on head and neck cancers so far has not been tested. The main objective of this research was to investigate biomarkers which could predict response of head …
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… four primary end points: tumour response rate, disease free survival, overall survival and health related quality of life. Health related quality of life (HRQoL) is a multidimensional concept, which encompasses a patient’s perceptions of both negative and positive aspects of the four main …
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Aspirin Use Is Associated with Improved Outcomes in Inflammatory Breast Cancer Patients
… at two institutions, were reviewed. Overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS) were performed using Kaplan-Meier analysis. Univariate and multivariable logistic regression models were used to identify significant associated factors. …
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Influence of Preoperative Transcatheter Arterial Chemoembolization on Gene Expression in the HIF-1α Pathway in patients with Hepatocellular Carcinoma
… rate (80 vs. 36%, P=0.00402) and shorter disease-free survival (DFS) time (11.9 vs. 35.7 months, p=0.0182). TACE was an independent prognostic factor for recurrence (p=0.007) and poor DFS (p=0.010) in a multivariate analysis. Immunohistochemical staining revealed in vivo activation of …
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Prognostic Value of Bone Marrow Micrometastasis Detected by Nnested RT-PCR for Cytokeratin 19 and Mammaglobin in Breast Cancer
… phase frequently undergo distant metastasis, and survival of patients is greatly dependent on distant metastasis. Occurrence of micrometastasis has been suggested to relate with prognostic features of breast cancer, such as lymph node metastasis and the presence of vascular invasion. The aim of …
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Influence of missing explanatory variables and longitudinal assessments in breast cancer clinical trials
… imputed by standard methods before analysis of disease-free survival (DFS) and the performance of the imputation methods is considered. Then the influence of missing observations of an outcome variable assessing safety is considered. Repeated measures analysis of a safety assessment is …
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