Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"Disease activity"”.
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Novel positron emission tomography applications for imaging cardiovascular disease activity
… and a key pathological feature of cardiovascular disease. Calcification activity can now be imaged using 18F-sodium-fluoride positron emission tomography and computed tomography which targets microcalcification (diameter <50 μm), providing different information to established macroscopic …
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Chemokine Ligand-3 (CCL3) as a Novel Mediator of Inflammatory Bowel Disease Activity
Inflammatory bowel disease (IBD) is characterized by dysregulation of the immune system, driven in part by pro-inflammatory macrophage polarization. Chemokine ligand-3 (CCL3) is a chemokine known to mediate Th1 responses in inflammatory conditions and act to polarize M1 macrophages at the site of …
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Imaging of abdominal aortic aneurysm disease activity and implications for endovascular aneurysm repair
… risk of rupture due to presumed active aneurysm disease. Endovascular aneurysm repair (EVAR) is one treatment modality which reduces the procedural morbidity and mortality associated with open surgical repair. However, EVAR patients can develop complications such as leaks behind their stent graft …
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Circulating T-cell subsets in psoriasis- relation to disease activity and response to systemic treatments-
Contains fulltext : 71397.pdf (Publisher’s version ) (Open Access)
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Beta2-microglobulin and antichromatin antibodies can be a disease activity markers in Systemic Lupus Erythematosus in Koreans
… that their presence is associated with lupus disease activity. We have investigated the clinical significance of beta2-microglobulin and antichromatin antibodies in Korean SLE patients. MATERIALS AND METHODS: Blood samples were collected from SLE patients (n＝100), rheumatoid arthritis (RA) …
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Development and validation of the BILAG-2004 Index for the assessment of disease activity in systemic lupus erythematosus
… the BILAG-2004 index for the assessment of disease activity in patients with [systemic lupus erythematosus] SLE had involved several validation studies. The reliability of this index was shown in 2 exercises, as assessed by level of agreement, kappa statistic, ICC and disagreement between …
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Determinants of patient and physician global assessment of disease activity and their discrepancies amongst South Africans with Rheumatoid Arthritis
… RA attending a tertiary hospital. Demographic, disease-specific, and patient-reported outcome data were collected. A discordance score was calculated by subtracting the PhGA score from the PGA score, and discordance was defined as PGA-PhGA ≥ 2.5. Determinants of PGA, PhGA, and determinants were …
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Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity
… colitis (UC) are important in the evaluation of disease activity. An important symptom is that which 1) occurs during flares, 2) improves during effective therapy, and 3) resolves during remission. Twenty eight symptom domains were evaluated. Sixty subjects were surveyed, rating each symptom on …
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
… S100A8/A9 has been suggested as a biomarker of disease activity in patients with systemic juvenile idiopathic arthritis or adult-onset Still’s disease (AOSD). We investigated the clinical significance and the pathogenic role of this marker in AOSD. Materials and Methods: Serum samples were …
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
… (SLE) and can lead to chronic kidney disease (CKD). Diagnosis of lupus nephritis (LN) is dependent on renal biopsy. Due to its invasiveness, repeat renal biopsy for monitoring disease activity is not recommended, thus creating a need for noninvasive and accurate biomarkers. Monocyte …
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Improving clinical outcomes in rheumatoid arthritis: a patient centred approach
… rheumatoid clinical phenotypes; their higher disease activity scores may not fully reflect disease activity. Despite changes in treatment over the years their disease activity scores have not improved significantly, unlike RA patients in general. Different treatment strategies are needed to …
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The Effects of Pregnancy on Systemic Lupus Erythematosus
… these exacerbations will have on the basic disease process. The purpose of this study was to investigate the effect pregnancy would have in precipitating exacerbation of disease activity. The investigation was carried out by comparing two matched groups of women with SLE, one group pregnant …
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Osteoporosis in rheumatoid arthritis
… data, as well as information pertaining to the disease. Cortical bone mass was measured at the metacarpals and left femur, using an automated, computer-controlled technique. Trabecular bone was evaluated at the left femur (Singh index) as well as at the 3rd lumbar vertebra (Saville index). Bone …
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Differential Expression of T Cell Immunoglobulin- and Mucin-Domain-Containing Molecule-3 (TIM-3) According to Activity of Behçet's Disease
… inflammatory multisystemic disorder, Behçet’s disease (BD). However, TIM-3 expression and function in BD has not been investigated. PURPOSE: In this study, its was examined that the surface expression of TIM-3, the expression of TIM-3 protein and the TIM-3 mRNA in peripheral blood mononuclear …
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Improving quality of care in inflammatory bowel disease: treatment targets and body composition
… Quality care for people with inflammatory bowel disease (IBD) aims to modify the course of disease and normalise quality of life (QoL). Treatment directed at objective inflammation has been shown to improve outcomes in IBD, yet represents a paradigm shift for clinicians trained to manage symptoms …
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Protease activity sensors for monivasive diagnosis and monitoring of pulmonary diseases
Effective disease management requires high quality and accurate information about disease state. As science and technology have evolved, the history and physical exam, once the foundations of the diagnostic workflow, have been supplemented with modalities that allow physicians to peer inside the …
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A Cross-Sectional Study Examining Lifestyle and Rheumatoid Arthritis
… arthritis (RA) is a chronic inflammatory disease that affects the synovial joints. RA affects 0.5-2% of the population. Though it is predominantly a progressive disease, adjunct therapy may slow the destructive pathway or alleviate affiliated symptoms. This study examined the effects of …
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Evaluation of Select Food Additive Exposures in Children with Crohn's Disease
… Food Additive Exposures in Children with Crohn’s Disease C Kaiulani Swan Chair of the Supervisory Committee: Johanna Lampe, University of Washington Research Professor Epidemiology Crohn’s Disease (CD) is a chronic, debilitating inflammatory bowel disease and recent research has revealed the …
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Exercise-Based Upper Limb Rehabilitation In Rheumatoid Arthritis
… arthritis (RA) is a chronic, systemic, disabling disease which reduces independence, quality of life, and longevity. Upper limb impairment causes considerable disability, contributes to work incapacity, and has substantial monetary and non-monetary, personal and societal …
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Significance of leptin and ghrelin in systemic lupus erythematosus in Koreans
… parameters, systemic lupus erythematosus disease activity index (SLEDAI) and systemic lupus international collaborative clinics/American College of Rheumatology damage index (SLICC/ACR DI). RESULTS: The leptin levels of the SLE group (136.20 ± 96.77 pg/mL) were higher than those of the NC …
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