Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Disease Screening"”.
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Peripheral Arterial Disease Screening of an Underserved High Risk Population
… with decreased access to appropriate health screening and therapeutic interventions often present with increased risks for peripheral arterial disease. Some patients with peripheral arterial disease are asymptomatic and may defer treatment while others present with occlusive disease requiring …
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A covariate-adjusted classification model for multiple biomarkers in disease screening and diagnosis
… have been widely used to improve the accuracy in disease screening and diagnosis. However, it is seldom to include covariates such as gender and age at diagnosis into these classification procedures. It is known that biomarkers or patient outcomes are often associated with some covariates in …
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Design of a mobile kit for cardiovascular disease screening in resource constrained environments
… away from high mortality rates due to infectious diseases. This trend has however been accompanied by an increase in chronic disease incidence, in particular Cardiovascular Diseases (CVDs). In countries that are making this epidemiological transition, such as India, chronic diseases are also a …
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Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort
Objectives: Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical …
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Design and validation of mobile kit and machine learning algorithms for pulmonary disease screening and diagnosis
Pulmonary diseases are responsible for more than 15% of deaths worldwide. Much of this burden is concentrated in the developing world, where these diseases cause 19% of deaths. In much of the developing world, pulmonary diseases are under-diagnosed and misdiagnosed because the correct equipment is …
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Robust and Equitable Public Health Screening Strategies, with Application to Genetic and Infectious Diseases
Public health screening plays an important role in the overall healthcare system. As an example, consider newborn screening, a state-level initiative that screens newborns for life-threatening genetic disorders for which early treatment can substantially improve health outcomes. Another topical …
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Optical diffraction-based silicon sensors for the detection of DNA sequences
… within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease …
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Optimal Data-driven Methods for Subject Classification in Public Health Screening
… of a certain binary characteristic (e.g., a disease) in a subject, is an essential component of public health screening. For many diseases, the concentration of disease-related biomarkers may exhibit a wide range, particularly among the disease positive subjects, in part due to variations …
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Machine learning models for screening and diagnosis of infections
… group has focused on developing tools to aid in disease screening for patients in developing areas over the past seven years. For this thesis project, I developed a Logistic Regression model that screens for infections in surgical site wounds using features extracted from visible light images of …
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Modular CRISPR-diagnostics for Infectious Diseases
Infectious diseases continue to represent a significant fraction of worldwide disease burden. A critical part of lowering this burden entails effective testing strategies, as underscored by the ongoing COVID-19 pandemic. The goals of diagnostics, screening, and surveillance have demanded distinct …
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Topics in Heterogeneous Group Testing
… a variety of applications, including infectious disease screening, drug discovery, and genetics. Statistical research in group testing generally splits into two areas: classification and estimation. Following this bifurcated structure, this dissertation consists of three research problems which …
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Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging
Diseases of the gastrointestinal (GI) tract are typically diagnosed by random biopsy of tissue, which samples only a small area and often misses focal neoplasias. Existing endoscopic visualization tools including white light endoscopy, narrowband imaging and confocal laser endomicroscopy have …
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Risk Prediction and Value of Polygenic Risk Scores in Colorectal Cancer Screening
… (PRS), have shown promises to guide personalized screening for colorectal cancer (CRC). Continuous efforts to improve PRS risk prediction are needed for clinical use, and understanding its added value of guiding CRC screening is needed to inform screening guidelines, clinical adoption, and …
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Molecular diagnosis of cancer using ambient ionization mass spectrometry
… previously used to analyze and differentiate disease state (i.e. tumor and normal) and in some cases tumor subtype of human liver, kidney, bladder, testicular, prostate, and brain cancers. DESI-MS imaging is an ideal method for disease diagnosis, because it can be used to directly correlate …
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Detection and Classification of Diabetic Retinopathy Pathologies in Fundus Images
Diabetic Retinopathy (DR) is a disease that affects up to 80% of diabetics around the world. It is the second greatest cause of blindness in the Western world, and one of the leading causes of blindness in the U.S. Many studies have demonstrated that early treatment can reduce the number of …
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Relationship between Ideal clinic status determination and measures of PHC performance, utilisation and expenditure per PHC facility headcount
… care, TB/HIV treatment, and non-communicable disease screening are explored using panel regression models. Controlling for heterogeneity across clinics and for year, increases in ICRMP percentage scores over time appear to be associated with very small magnitude increases in childhood PHC …
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Modeling the health of free-living Illinois herptiles: an integrated approach incorporating environmental, physiologic, spatiotemporal, and pathogen factors
… of physical examination, qPCR pathogen screening, and clinical pathology (box turtles). Mortality events were characterized as they occurred and spatiotemporal data were used to screen for locations and times associated with pathogen presence or poor health outcomes. Diagnostic tests …
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Optimal Screening for Preclinical Diseases
Certain diseases comprise an initial asymptomatic period during which they can be identified only by a screening test. In many such cases, early detection translates into benefits of more treatment options and potentially better prognosis. In this dissertation, we consider the optimal policy to …
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Development of machine learning algorithms for screening of pulmonary disease
Pulmonary diseases are a leading cause of death worldwide. Much of their burden disproportionately affects the developing world. The MIT Mobile Technology Lab has developed a Mobile Kit which screens and diagnoses COPD and asthma. In this thesis, we analyze and further develop tools in this kit. …
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