Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 762 for “"Disease Progression"”.
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Dynamic Prediction of Disease Progression With Longitudinal Data
… model for dynamically predicting end-stage renal disease with the competing risk of death, motivated by a study on chronic kidney disease, which efficiently handles the computational challenges of using multiple longitudinal biomarkers through a different factorized likelihood approach and EM …
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Machine Learning Approaches for Characterizing ALS Disease Progression
… Sclerosis (ALS) is a fatal neurodegenerative disease that is complex in its onset, pattern of spread, and disease progression. This heterogeneity makes it challenging to identify potential therapeutics and to evaluate their effectiveness in slowing progression. At the same time, a better …
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The Effect of Treatment on Peri-Implant Disease Progression
… the effect of treatment on peri-implant disease progression, with particular emphasis on the differential outcomes based on baseline disease severity. Materials and Methods This retrospective analysis examined 323 patients with 1003 implants treated between 2010-2024. Clinical data …
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The modulation of autoimmune disease progression in mouse models
… in the development of the two human autoimmune diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are temporary and accompanied …
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Neuromuscular Ultrasound as a Biomarker of Disease Progression in ALS
… may be a viable option for monitoring ALS progression. Other biomarkers currently available have limiting factors such as subjectivity and invasiveness. 12 participants took part in our study and we measured the thickness of four muscle groups including the biceps brachii, tibialis …
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Time Course of Disease Progression of PRPF31-Mediated Retinitis Pigmentosa
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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CD166 modulates disease progression and osteolytic disease in multiple myeloma
… CD166 is involved in MM and plays a role in MM progression has not been addressed. We demonstrated that a fraction of all human MM cell lines tested and MM patients’ BM CD138+ cells express CD166. Additionally, CD166+ cells preferentially home to the BM of NSG mice. Knocking-down (KD) CD166 …
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Patterns and biomarkers of X-linked dystonia parkinsonism disease progression
… Philippines. Though this is a relatively novel disease, efforts have been directed towards solving the etiology, which currently points to an expansion in the TAF1 gene. This gene plays a regulatory role in transcription that may be compliant with treatment options. To set up the basis for …
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Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
… the extreme genomic complexity underlying this disease. HGSOC is characterised by somatic copy number aberrations (CNAs) and structural variants driven by extreme chromosomal instability (CIN). Importantly, CIN is a key mediator of clonal diversity which fuels the development of treatment …
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
… approaches to chemotherapy refractory disease. Collectively, these studies provide important insights into the genetic and epigenetic factors driving neuroblastoma, and suggest new opportunities for pathway-targeted therapies.
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Effect of Cigarette Smoking on Disease Progression in Idiopathic Parkinson's Disease Patients
… the development of idiopathic Parkinson’s disease (IPD). Despite this, there have been few studies focusing on whether cigarette smoking is able to slow IPD disease progression. The few that have examined this issue must be regarded with care due to their intrinsic methodological problems …
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The neuroinflammatory basis of disease progression and cognitive impairment in Parkinson's disease
Parkinson’s disease (PD) is classically defined as a movement disorder, but a large proportion of patients also develop cognitive dysfunction as the disease progresses. Currently, it is not fully understood why some patients experience mainly movement-related features, whilst others suffer from a …
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Personalized Gaussian process-based machine learning models for forecasting Alzheimer's Disease progression
… data collected from the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Thus, this thesis explores the impact of PML in the context of predicting the progression of Alzheimer's disease (AD) by predicting various cognitive, clinical, and behavioral metrics known to be …
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Metabolic Adaptations of Ovarian Cancer Metastases to Physiological Conditions and Disease Progression
Ovarian cancer is the fifth leading cause of all cancer deaths in women and the most lethal gynecologic cancer in the United States. During metastasis, cancer cells exfoliate from the primary tumor and aggregate to form spheroids, enhancing their survival within the peritoneal cavity during …
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ADInsight: A Multimodal and Explainable Framework for Alzheimer's Disease Progression and Conversion Prediction
… framework centered on predicting Alzheimer's disease (AD) conversion, particularly for those at the early stage of mild cognitive impairment (EMCI). Beginning with an examination of models grounded in individual research modalities, such as clinical data and advanced imaging, the research …
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Investigating speech technology for monitoring disease progression in the context of neurodegenerative disease
… most frequent cause of dementia is Alzheimer’s Disease (AD), which is known to start silently up to 20 years before observable symptoms appear. Therefore, interdisciplinary research efforts are focusing on unravelling disease progression and developing strategies for secondary prevention (i.e. …
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An investigation of the role of mucin gels in disease progression and transmission
… role of mucins in these within-host and external disease processes. In mucosal layers within the host, mucus plays an important role in limiting the progression of infectious pathogens. The pathogen’s ability to penetrate mucus, in many cases, determines its ability to reach its target cell and …
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Cell-based sensors for quantifying cell health and disease progression in engineered systems
… healthy beings, while dysfunctional cells cause disease. Studying disease requires an understanding of how cells become dysfunctional from physiological states. Gaining this insight in vitro involves subjecting cells to relevant microenvironments and utilizing methodologies for assaying cells. …
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Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data
… such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross- sectional nature of training and prediction processes. Finding …
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The Prediction Model of Disease Progression of Micro and Macro-complication in Diabetes Mellitus
… clinical nephropathy, end-stage renal disease (ESRD), and ESRD with transplant. Third, diabetic neuropathy model was defined as peripheral neuropathy and lower-extremity amputation. Forth, diabetic cardiovascular disease model was defined as unrecognized myocardial infarction, history …
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