Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 101 for “"Disease Pathology"”.
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Integrative multiomic insights into Alzheimer’s disease pathology
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, currently afflicting around 900,000 patients in the United Kingdom. However, therapeutic avenues and factors that can exacerbate AD pathologies remain unclear. Hence, there is an urgent need for a better …
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The role of transthyretin in Alzheimer disease pathology
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Protein spatiotemporal dynamics in gene regulation and disease pathology
… in the context of gene regulation and disease pathology. We find that the apparent diffusion of transcription factors (TFs) is preferentially partitioned into slowly diffusing states by interacting with RNA, leading to enhanced chromatin occupancy and gene expression (Oksuz et al., …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in GBA1 and …
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Traumatic Brain Injury Accelerates Alzheimer’s Disease Pathology in the TgF344-AD Rat Model
… Injury (TBI) is a risk factor for Alzheimer’s disease (AD). TBI and AD have common overlapping pathologies. However, the underlying mechanisms are not clearly understood, and there are no effective treatments for TBI and AD. Aim of the study is to test the effect of TBI on the progression of AD …
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Towards a translational understanding of colonic bacteria in Crohn's disease pathology
Crohn’s disease (CD) is a chronic inflammatory condition of unknown aetiology, with the microbiota thought to be a major contributor to the disease. This thesis aimed to investigate the potential role of the gut microbiota in this context. The approaches taken were to examine CD associated …
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Modulation of Alzheimer’s Disease Pathology by Collagen-Induced Rheumatoid Arthritis in APP/PS1 Mice
… enhance or reduce the progression of Alzheimer’s disease (AD). The present study was performed to directly explore the effects of collagen-induced rheumatoid arthritis (CIA) on cognitive function, amyloid plaque formation, microglial activation, and cerebrovascular pathology in the cortex and …
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Co-opting disease pathology for personalized medicine; utilizing endogenous biomaterials to generate theranostic nanoparticles
Various biomolecules and cell types have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid (HAuCl4) is introduced.We have demonstrated the capacity and utility of nanoparticles generated from endogenous biomolecules through three examples which can …
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Identification of the cellular mechanisms undelying the contribution of stress and glucocorticoids to Alzheimer's disease pathology
… (GC) in the etiopathogenesis of Alzheimer’s disease (AD), a disease marked by severe memory impairments as well as alterations in mood and emotional state. The experiments described in this dissertation represent an attempt to establish the cellular mechanisms through which stress and GC may …
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Examining the relationship between mitochondrial dysfunction and Parkinson's disease pathology: a review on potential risk factors and treatments for parkinsonism
… histological risk factor for Parkinson’s disease is the development of alpha-synuclein clumps, known as Lewy Bodies, in the substantia nigra portion of the midbrain. However, the etiology of the disease remains unknown. Neurons are heavily dependent on aerobic respiration for ATP due to …
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Amelioration of Alzheimer's Disease Pathology in 12-Month-Old hAPP(SweInd) Transgenic Mice After Treatment with a Cysteine Rich Whey Supplement, Immunocal®
… signaling play a pathogenic role in Alzheimer’s disease (AD). Thus, strategies aimed at correcting Reelin deficits may provide a novel therapeutic approach to treating AD. The cysteine-rich, whey protein supplement, Immunocal®, has recently been shown to rescue Reelin expression in a mouse model …
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Altered FRG1 Levels During Xenopus Laevis Development Leads to Muscular and Vascular Phenotypes Supporting a Role for the Misregulation of FRG1 in FSHD
… which in turn is what ultimately leads to the disease pathology. FRG1 (FSHD region gene 1) is a leading candidate gene whose misexpression may lead to FSHD. As FSHD pathology is most prominent in the musculature, most research and therapy efforts have focused on muscle cells. However, between …
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Investigating the Use of [18-F] tau-PET Imaging as a Biomarker of tau Pathology in Retired Athletes at Risk of Neurodegeneration
… neurodegeneration as seen in Alzheimer’s disease and chronic traumatic encephalopathy. Chronic traumatic encephalopathy is characterized by abnormal accumulation of tau protein in the brains of affected athletes in a pattern distinct from other neurodegenerative diseases. There is …
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Synaptic Excitatory to Inhibitory imbalance in Alzheimer’s Disease
Alzheimer’s disease is the most common cause of dementia worldwide, and it is characterized by progressive impairment of cognitive performance, brain atrophy, neuronal and synaptic loss, and abnormal aggregation of amyloid beta and tau proteins. Notably, prodromal Alzheimer’s disease is …
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The Molecular Interaction Between Type Ii Diabetes and Alzheimer’S Disease Through Cross-Seeding of Protein Misfolding
… population of the world aging, the prominence of diseases such as Type II Diabetes (T2D) and Alzheimer’s disease (AD) are on the rise. In addition, patients with T2D have an increased risk of developing AD compared to age-matched individuals, and the number of AD patients with T2D is higher than …
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Characterization of a Drosophila model of Huntington's disease
Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, …
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Elucidation of an oral drug delivery mechanism to the mammalian gastrointestinal tract via an engineered T4 phage
Current treatments of gastrointestinal (gut) disease are limited by high dosing frequency, patient noncompliance, and complications circumventing the harsh conditions of the upper gastrointestinal tract (e.g. stomach), leading to therapeutic degradation. Bacterial cells were previously explored as …
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