Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Disease Models, Animal"”.
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Vulnerability and Resilience to Social Defeat: The Role of Neuroplasticity Within the Mesolimbic Dopamine Circuit
… viral-mediated gene transfer and genetic mouse models, we demonstrate how these adaptations are causally linked to a vulnerable phenotype. We also show that molecular recapitulations of adaptations associated with the unsusceptible phenotype are sufficient to promote resilient behavior. Our …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… We used a set of patient-derived xenograft mouse models of melanoma, in which the metastatic potential of individual tumor lines correlated strongly with the history of metastasis in the patient donors. Six tumor lines with low metastatic potential (L-met) and nine with high metastatic potential …
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Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations and Identification of Novel Host Barriers to Poliovirus Neuropathogenesis
… to revert attenuating mutations, contributing to disease and complicating treatment and vaccine development. Despite worldwide epidemics in the early nineteenth century, paralysis from poliovirus is a rare event occurring in less than 1% of poliovirus infections. This suggests the presence of …
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Mucosal HIV-1 Transmission in Humanized Mice
… The social and economic toll of this disease has created an urgency to develop and implement novel approaches capable of preventing HIV-1 transmission. Yet this process has been hindered by the lack of adequate small animal models for pre-clinical efficacy and safety testing. Given the …
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
Lung cancer accounts for more cancer-related deaths than any other cancer type among both men and women. The overall increase in radiation risk for human cancer types has been substantiated by the epidemiological data obtained from atomic bomb survivors and uranium mine workers. The lung has a …
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
… (Activin Receptor-like Kinase 6b) in the mutant animals. Alk6b is a member of the TGF-beta/BMP superfamily of receptors. BMP signaling has diverse roles including regulation of cell proliferation, differentiation, embryonic development, germ cell specification and gonadogenesis. Misregulation of …
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Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
… The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal …
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The Effect of Grapes in Mice with Alzheimer's Disease and Brain Injury
<p>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and memory deficits and deposits of amyloid beta (Aβ) in the cortex and hippocampus are thought to be significant contributors to the disease process. Increasing evidence suggests that foods rich in …